Clinical evaluation following the use of mineralized collagen graft for bone defects in revision total hip arthroplasty

Huang, Cheng; Qin, Liwu; Yan, Wei; Weng, Xisheng; Huang, Xiangjie

doi:10.1093/rb/rbv022

Cited by 15 publications

(8 citation statements)

References 25 publications

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“…Our previous study had predicted that nHA collagen plug might be an ideal bone graft material. 19–21 In our recent study, 22 good results had been obtained, but there was no enough evidences to prove its effectiveness, especially the evidences of tissue reaction and the implant degradation. Because of these shortcomings or defects, a further research of bone regeneration and resorption of two materials is necessary to advance membrane properties, particularly the rate of materials degradation proceeding at varying time.…”

Section: Introductionmentioning

confidence: 97%

Effects of the bilayer nano-hydroxyapatite/mineralized collagen-guided bone regeneration membrane on site preservation in dogs

et al. 2017

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This study was aimed at assessing the effects of the porous mineralized collagen plug with or without the bilayer mineralized collagen-guided bone regeneration membrane on alveolar ridge preservation in dogs. The third premolars in the bilateral maxilla of mongrel dogs ( N = 12) were extracted. Twenty-four alveolar sockets were thus randomly divided into three groups: membrane + collagen plug (MP, n = 8), nonmembrane + collagen plug (NP, n = 8) and blank group without any implantation (BG, n = 8). Radiographic assessment was carried out immediately and in the 2nd, 6th, and 12th week after surgery. The bone-repairing effects of the two grafts were respectively evaluated by clinical observation, X-ray micro-computed tomography examination, and histological analysis in the 8th and 12th week after surgery. Three groups presented excellent osseointegration without any inflammation or dehiscence. X-ray micro-computed tomography and histological assessment indicated that the ratios of new bone formation of MP group were significantly higher than those of NP group and BG group in the 8th and 12th week after surgery ( P < 0.05). As a result, the porous mineralized collagen plug with or without the bilayer mineralized collagen-guided bone regeneration membrane could reduce the absorption of alveolar ridge compared to BG group, and the combined use of porous mineralized collagen plug and bilayer mineralized collagen-guided bone regeneration could further improve the activity of bone regeneration.

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Section: Introductionmentioning

confidence: 97%

Effects of the bilayer nano-hydroxyapatite/mineralized collagen-guided bone regeneration membrane on site preservation in dogs

et al. 2017

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“…23 Results have found that our experimental group which used porous mineralized collagen plug alone produced more new bones compared with the blank control group by X-CT analysis. In our new study, Huang et al 24 suggested that massive bone defects of acetabulum and proximal femur were reconstructed completely by mineralized collagen graft, and radiographs taken at 3rd month, 6th month, and 12th month indicated the bone grafts were well remodeled. Beside new bone formation, the biodegradation of the material was also another important factor to be considered.…”

Section: Discussionmentioning

confidence: 80%

Test in canine extraction site preservations by using mineralized collagen plug with or without membrane

Sun

Wang

et al. 2015

J Biomater Appl

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The aim of this study was to discuss the feasibility of porous mineralized collagen plug and bilayer mineralized collagen-guided bone regeneration membrane in site preservation in extraction sockets. The third mandibular premolars on both sides were extracted from four dogs, thus there were 16 alveolar sockets in all dogs and were randomly assigned into three groups. Group A had six alveolar sockets, and groups B and C had five alveolar sockets, respectively. Each alveolar socket of group A was immediately implanted with a porous mineralized collagen plug and covered with a bilayer mineralized collagen-guided bone regeneration membrane after tooth extraction. Alveolar sockets of group B were implanted with porous mineralized collagen plug only, and group C was set as blank control without any implantation. The healing effects of the extraction sockets were evaluated by gross observation, morphological measurements, and X-ray micro-computed tomography after twelve weeks. Twelve weeks after operation, both groups A and B had more amount of new bone formation compared with group C; in terms of the degree of alveolar bone height, group A was lower than groups B and C with significant differences; the bone mineral density in the region of interest and bone remodeling degree in group A were higher than those of groups B and C. As a result, porous mineralized collagen plug could induce the regeneration of new bone in extraction socket, and combined use of porous mineralized collagen plug and bilayer mineralized collagen guided bone regeneration membrane could further reduce the absorption of alveolar ridge and preserve the socket site.

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“…кроме того, растет число пациентов, подвергшихся неоднократным ревизиям с тяжелыми дефектами костей [4]. при этом ревизионные операции являются технически более сложными из-за наличия рубцовых изменений параартикулярных мягких тканей, структурных изменений кости, а также проблем с удалением ранее установленных конструкций [6].…”

Section: Bone and Soft Tissues Integration In Porous Titanium Implantunclassified

Bone and Soft Tissues Integration in Porous Titanium Implants (Experimental Research)

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Денисов

et al. 2018

Traumatology and Orthopedics of Russia

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Aim. It’s common that revision arthroplasty of the large joints demands replacing of bone defects of irregular geometrical shapes and simultaneous restoring of support ability and ability to integrate surrounding muscular and tendinous structures into an implant that is required for a complete restoration of joint function.The purpose.To experimentally study the process of integration for muscular and bone tissue as well as tendinous and ligamentous structures into porous titanium materials.Material and methods. During in vivo experiment the authors created a standardized bone defect in 6 rabbits of chinchilla breed at the point of patella ligament attachment as well as a delamination area of muscular tissue in latissimus dorsi. Both knee joints and both latissimus dorsi were used in each animal. Study group included titanium implants with three-dimensional mesh structure. Control group — solid titanium implants with standard porosity. Titanium implants were produced by additive technologies with preliminary prototyping. The porosity corresponded to trabecular metal, striations — 0.45, pores size —100–200 microns. Study and control components were implanted in the identical conditions into the corresponding anatomical sites. Postoperative AP and lateral roentgenograms of knee joints were performed for all animals. Morphological research was conducted on day 60 after the implantation and strength properties were studied at day 90 after the implantation.Results.The authors observed bony ingrowth into implant pores with minimal volume of fibrous tissue, a distinct connective integration was reported represented by a dense fibrous tissue in the pores of components implanted into the muscular tissue. Testing of fixation strength of the study implants demonstrated a clearly superior strength of soft and bone tissue integration into the experimental mesh implants produced using additive technologies.

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Clinical evaluation following the use of mineralized collagen graft for bone defects in revision total hip arthroplasty

Cited by 15 publications

References 25 publications

Effects of the bilayer nano-hydroxyapatite/mineralized collagen-guided bone regeneration membrane on site preservation in dogs

Effects of the bilayer nano-hydroxyapatite/mineralized collagen-guided bone regeneration membrane on site preservation in dogs

Test in canine extraction site preservations by using mineralized collagen plug with or without membrane

Bone and Soft Tissues Integration in Porous Titanium Implants (Experimental Research)

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