Clinical Evaluation of Cryoprecipitated Factor VIII

Can Hemophilic Patients Be Adequately Maintained with Cryoprecipitates? Or Is it Desirable or Even Necessary to Manufacture and Administer Highly Concentrated AHF Products?

“…It can be maintained above the baseline level of 40% throughout the necessary healing period of 2-3 weeks (or as long as is required). , Simson et al [1966], Dormandy K. M. [1968], and Mazza et al [1970] may be quoted more or less at random from the vast literature on this subject, to illustrate these points.…”

Human Factor VIII Prepared by Cryoprecipitation

“…In all the reports on treatment of the classical haemo philia A [2,5,8,12,13,15,16,18,30,34,39] and von WiUebrand's disease [4,15,20], the clinical results are satisfactory. In particular, this treatment now makes it possible to carry out major operations on haemophiliacs [3,8,38,39].…”

“…Supernatant plasma constitutes a valuable source of factors IX and XI for the treatment of haemophilia B (Christmas disease) and Rosenthal's disease (PTA deficiency) [4,5,38].…”

“…They had pre viously occurred with plasma in two other cases but could easily be controlled with antihistamines. One worker [38] reports a slight feverish reaction 6 to 8 h after each dose. Urticaria with a tempera ture, headaches and a drop in blood pressure can be observed in the early stages if immersion into the freezing mixture of the plastic bag containing the plasma or the precipitate is carried out without protecting the latter with a second and more impermeable bag.…”

Human Factor VIII Prepared by Cryoprecipitation1

“…. Composition Total proteins [8,9,10,15,28,371 Fibrinogen, factor I 18,9,15,28,371 Prothrombin, factor I1 [9, 15,28,371 Proaccelerin, factor V [9,15,281 Proconvertin, factor VII [9,15,281 Antihaernophilic globulin, antihaemophilic factor A, factor VIII [S, 8,9,10,12,15,16,28,34,37,38,421 Antihaemophilic factor B, Christmas factor, factor I X 15, 9,28,37,381 Stuart-Prower factor, factor X [9, 15, MEYER et al [1967] x 13…”