Clinical experience with post-orgasmic illness syndrome (POIS) patients—characteristics and possible treatment modality

Reisman, Yacov

doi:10.1038/s41443-020-0314-9

Cited by 16 publications

(16 citation statements)

References 17 publications

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“…The first successful treatment has been reported with human chorionic gonadotropin [58], which seems to substantiate spermidine depletion in the etiology [59]. Moreover, Reisman presented successful treatment in 57% of POIS patients with the highly selective alpha 1 A-blocker, Sidosin [1]. The findings of Reisman could be explained by Sidosin improving blood flow and the respiratory capacity of the affected proprioceptive nerves, preventing the neuroenergetic TAD-like lesion at the terminals of these nerves in a high percentage of patients.…”

Section: Testing This Hypothesis and Possible Interventionsmentioning

confidence: 90%

“…The depletion of spermidine also seems to play a critical role in the bidirectional glial-neuronal communication in the central nervous system and in the onset of low-grade neuroinflammation. Furthermore, the activated NM-DARs in a spermidine depleted state could cause symptoms of POIS, including irritability and a foggy feeling in the head [1].…”

Section: Activated Nmdars and Low Grade Neuroinflammationmentioning

confidence: 99%

“…Post orgasmic illness syndrome (POIS) is a rare, mysterious, but most likely underreported, debilitating chronic condition with unknown pathomechanism and uncertain treatment. The name of POIS was introduced and described first by Waldinger and Schweitzer [1]. It was considered by Waldinger as an autoimmune reaction induced by specific cytokines to prostatic tissue produced seminal fluid [2]; however the study of Jiang et al [3] could not confirm this hypothesis.…”

Section: Introductionmentioning

confidence: 99%

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Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Sonkodi

Kopa

Nyírády

2021

Cells

133

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Post orgasmic illness syndrome is a rare, mysterious condition with an unknown pathomechanism and uncertain treatment. The symptoms of post orgasmic illness syndrome last about 2–7 days after an ejaculation. The current hypothesis proposes that the primary injury in post orgasmic illness syndrome is an acute compression proprioceptive axonopathy in the muscle spindle, as is suspected in delayed onset muscle soreness. The terminal arbor degeneration-like lesion of delayed onset muscle soreness is theorized to be an acute stress response energy-depleted dysfunctional mitochondria-induced impairment of Piezo2 channels and glutamate vesicular release. The recurring symptoms of post orgasmic illness syndrome after each ejaculation are suggested to be analogous to the repeated bout effect of delayed onset muscle soreness. However, there are differences in the pathomechanism, mostly attributed to the extent of secondary tissue damage and to the extent of spermidine depletion. The spermidine depletion-induced differences are as follows: modulation of the acute stress response, flu-like symptoms, opioid-like withdrawal and enhanced deregulation of the autonomic nervous system. The longitudinal dimension of delayed onset muscle soreness, in the form of post orgasmic illness syndrome and the repeated bout effect, have cognitive and memory consequences, since the primary injury is learning and memory-related.

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Section: Testing This Hypothesis and Possible Interventionsmentioning

confidence: 90%

Section: Activated Nmdars and Low Grade Neuroinflammationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Sonkodi

Kopa

Nyírády

2021

Cells

133

View full text Add to dashboard Cite

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“…Reismann et al also performed a combination of silodosin with ibuprofen 400 mg and prednisone 30 mg and reported improvement. 6 The modality of hormone therapy was also reported to provide improvement. Bolanos et al gave an injection with 1500IU hCG that was injected subcutaneously three times a week.…”

Section: Managementmentioning

confidence: 99%

“…Since the mechanism of POIS is not well understood, there is no clear effective treatment until now. 6 This review aims to provide a closer look at the definition and criteriaof POIS and discuss some updates on potential management options.…”

Section: Introductionmentioning

confidence: 99%

Post-orgasmic Illness Syndrome: A Closer Look

William

Pakpahan

Ibrahim

2020

IABJ

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Background: Post-orgasmic illness syndrome (POIS) is a rare condition in which someone experiences flu-like symptoms, such as feverish, myalgia, fatigue, irritabilty and/or allergic manifestation after having an orgasm. POIS can occur either after intercourse or masturbation, starting seconds to hours after having an orgasm, and can be lasted to 2 - 7 days. The prevalence and incidence of POIS itself are not certainly known. Reviews: Waldinger and colleagues were the first to report cases of POIS and later in establishing the diagnosis, they proposed 5 preliminary diagnostic criteria, also known as Waldinger's Preliminary Diagnostic Criteria (WPDC). Symptoms can vary from somatic to psychological complaints. The mechanism underlying this disease are not clear. Immune modulated mechanism is one of the hypothesis that is widely believed to be the cause of this syndrome apart from opioid withdrawal and disordered cytokine or neuroendocrine responses. POIS treatment is also not standardized. Treatments includeintra lymphatic hyposensitization of autologous semen, non-steroid anti-inflamation drugs (NSAIDs), steroids such as Prednisone, antihistamines, benzodiazepines, hormones (hCG and Testosterone), alpha-blockers, and other adjuvant medications. Summary: This syndrome still needs more research to understand its mechanisms to obtainclearer treatment. Besides that, the clinician's awareness is needed to recognize this syndrome so that it is not misdiagnosed.

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The first Tunisian case of postorgasmic illness syndrome: A case report

Hamdi

Charaa

Brahmi

et al. 2021

Clinical Case Reports

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The Postorgasmic illness syndrome (POIS) is a rare syndrome, recently described by two Dutch doctors Waldinger and Schweizer in 2002 1 which includes a set of physical and cognitive symptoms, appearing electively after ejaculation. It can last for several days. 2 About only 50 cases have been reported in the medical literature. 2 The Prevalence of POIS remains unknown, likely underdiagnosed still mysterious, owing to a paucity of studies, but is most probably underreported. Symptoms occur for a few seconds to a few hours after ejaculation, whether after intercourse, masturbation, or spontaneously during sleep. These disorders reproduce almost every ejaculation.We report a rare case of POIS that illustrates the clinical polymorphism and therapeutic difficulties of this syndrome and discusses etiopathogenic hypotheses. | CLINICAL CASEMr. MT, 32-year-old has been married to his cousin for 11 years and has 5 children. He had no somatic or psychiatric history. The patient has a secondary school level and works as a builder. He has no history of past or present substance use a side of smoking weaned for 4 years.He was referred to the psychiatric examination at Mannouba's Razi Hospital, Tunisia, after seeing urologists, neurologists, and general practitioners. Indeed, a few

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Clinical experience with post-orgasmic illness syndrome (POIS) patients—characteristics and possible treatment modality

Cited by 16 publications

References 17 publications

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Post-orgasmic Illness Syndrome: A Closer Look

The first Tunisian case of postorgasmic illness syndrome: A case report

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