Clinical Experience with the PreS1-containing Hepatitis B Vaccine (HG-3) in Different Nonresponder Groups

Enhancing the Immunogenicity of Liposomal Hepatitis B Surface Antigen (HBsAg) By Controlling Its Delivery From polymeric Microspheres

“…12 The presence of Pre-S2 and Pre-S1 peptides in this particle, which have antigenic determinants independent of the S protein, has made it more potent than commercially available recombinant HBsAg particles. 13,14 Herein, two types of MELs with a different PLL coating were developed and characterized in terms of HBsAg release rates in vitro and in vivo and the nature of the released particle (either as a naked particle or in the context of liposomes). Cryo-transmission electron microscopy (cryo-TEM) was employed first to directly image the hepatitis B antigen particles and then to detect their location within the liposomes.…”