Clinical Experience with the Use of Daptomycin in a Tertiary Care Teaching Hospital in Barcelona, Spain

Sandoval, Nancy; Grau, Santiago; Sorlí, Luisa; Montero, Milagro; Esteve, Erika; Horcajada, Juan Pablo

doi:10.2217/fmb.15.41

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…In those indications, the recommended dosing regimen ranges from 4 to 6 mg/kg [3]. Daptomycin is also used off-label in various indications, including bloodstream infections caused by Gram-positive agents others than S. aureus and bone and joint infections (BJI) [4]. Daptomycin use in patients with BJI is supported by its disposition in bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Implementation and Comparison of Two Pharmacometric Tools for Model-Based Therapeutic Drug Monitoring and Precision Dosing of Daptomycin

et al. 2022

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Daptomycin is a candidate for therapeutic drug monitoring (TDM). The objectives of this work were to implement and compare two pharmacometric tools for daptomycin TDM and precision dosing. A nonparametric population PK model developed from patients with bone and joint infection was implemented into the BestDose software. A published parametric model was imported into Tucuxi. We compared the performance of the two models in a validation dataset based on mean error (ME) and mean absolute percent error (MAPE) of individual predictions, estimated exposure and predicted doses necessary to achieve daptomycin efficacy and safety PK/PD targets. The BestDose model described the data very well in the learning dataset. In the validation dataset (94 patients, 264 concentrations), 21.3% of patients were underexposed (AUC24h < 666 mg.h/L) and 31.9% of patients were overexposed (Cmin > 24.3 mg/L) on the first TDM occasion. The BestDose model performed slightly better than the model in Tucuxi (ME = −0.13 ± 5.16 vs. −1.90 ± 6.99 mg/L, p < 0.001), but overall results were in agreement between the two models. A significant proportion of patients exhibited underexposure or overexposure to daptomycin after the initial dosage, which supports TDM. The two models may be useful for model-informed precision dosing.

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Section: Introductionmentioning

confidence: 99%