Clinical features and post-surgical outcome of patients with astroblastoma

Sughrue, Michael E.; Choi, Jay H.; Rutkowski, Martin J.; Aranda, Derick; Kane, Ari J.; Barani, Igor J.; Parsa, Andrew T.

doi:10.1016/j.jocn.2010.11.007

Cited by 53 publications

(70 citation statements)

References 56 publications

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“…Distinctive findings on MRI and CT include a well-circumscribed cystic mass with conspicuous enhancement, its being localized usually in the supratentorial region, especially in the frontal, parietal, and temporal lobes [2]. The solid component of the tumor often has a bubbly appearance on MRI, and these lesions have relatively little peritumoral edema for their large size, which may be related to the lack of local tumor infiltration into the surrounding brain tissue [1,7].…”

Section: Discussionmentioning

confidence: 99%

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A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study

et al. 2015

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Section: Discussionmentioning

confidence: 99%

“…On computed tomography (CT) and magnetic resonance imaging (MRI), the tumor is a well-demarcated, nodular or lobulated cystic mass with conspicuous contrast enhancement, usually located in the cerebral hemisphere [1,2].…”

Section: Introductionmentioning

confidence: 99%

A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study

et al. 2015

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“…According to the latest WHO classification of CNS tumors [6], astroblastoma is considered a high-grade glial neoplasm. However, an analysis of the published data [7] does not support this premise, as it was found that 5-year survival rates for patients receiving GTR were around 95%, with reports of survival exceeding 10 and even 20 years.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Astroblastoma: A Rare Case with a Review of the Literature

Khosla

Yadav²,

Kumar³

et al. 2012

Pediatr Neurosurg

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Astroblastoma is a rare glial tumor with uncertain histopathological origin and unpredictable clinical behavior. We present a case of an 11-year-old girl who presented with headache and blurring of vision for 2 months. A well-demarcated mass was found in the right frontoparietal lobe on a brain MRI. The patient was treated with total tumor resection followed by postoperative radiotherapy. Histologically, the features were suggestive of high-grade astroblastoma. The patient is alive and disease free 23 months after surgery. The characteristic radiological and histopathological features and treatment of this case are described with a literature review.

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“…1,2 They most frequently involve the cerebral cortex of children and young adults [1][2][3][4][5][6][7] and rarely the ventricles, cerebellum, brainstem, or spinal cord. [7][8][9] Their characteristic histopathological feature is the astroblastic pseudorosette. 1 These glial fibrillary acidic protein (GFAP)-immunoreactive structures consist of monopolar or less commonly cuboidal tumor cells radially oriented around a central blood vessel and thus represent a type of perivascular pseudorosette (Fig.…”

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confidence: 99%

Morphological and molecular features of astroblastoma, includingBRAFV600Emutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults

et al. 2016

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Background. Astroblastomas (ABs) are rare glial tumors showing overlapping features with astrocytomas, ependymomas, and sometimes other glial neoplasms, and may be challenging to diagnose. Methods. We examined clinical, histopathological, and molecular features in 28 archival formalin-fixed, paraffinembedded AB cases and performed survival analyses using Cox proportional hazards and Kaplan-Meier methods. Results. Unlike ependymomas and angiocentric gliomas, ABs demonstrate abundant distinctive astroblastic pseudorosettes and are usually Olig2 immunopositive. They also frequently exhibit rhabdoid cells, multinucleated cells, and eosinophilic granular material. They retain immunoreactivity to alpha thalassemia/mental retardation syndrome X-linked, are immunonegative to isocitrate dehydrogenase-1 R132H mutation, and only occasionally show MGMT promoter hypermethylation differentiating them from many diffuse gliomas. Like pleomorphic xanthoastrocytoma, ganglioglioma, supratentorial pilocytic astrocytoma, and other predominantly cortical-based glial tumors, ABs often harbor the BRAF V600E mutation, present in 38% of cases tested (n = 21), further distinguishing those tumors from ependymomas and angiocentric gliomas. Factors correlating with longer patient survival included age less than 30 years, female gender, absent BRAF V600E , and mitotic index less than 5 mitoses/10 highpower fields; however, only the latter was significant by Cox and Kaplan-Meier analyses (n = 24; P = .024 and .012, respectively). This mitotic cutoff is therefore currently the best criterion to stratify tumors into low-grade ABs and higher-grade anaplastic ABs.

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Clinical features and post-surgical outcome of patients with astroblastoma

Cited by 53 publications

References 56 publications

A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study

A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study

Pediatric Astroblastoma: A Rare Case with a Review of the Literature

Morphological and molecular features of astroblastoma, includingBRAFV600Emutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults

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