Clinical features and prognostic factors in papillary thyroid microcarcinoma depends on age

Abstract

PurposeClinical outcomes of papillary thyroid microcarcinoma (PTMC) vary. In general, age at diagnosis is an independent prognostic factor in conventional papillary thyroid carcinoma. However, it is unclear in patients of PTMC. The purpose of this study was to identify clinicopathologic features and prognostic factors of PTMC according to patients' age.MethodsFive hundred twenty-seven patients who received thyroid surgery and diagnosed as having PTC between January 2001 and December 2009 were included. The clinical data were retrospectively analyzed.ResultsWe divided the patients into two groups; group I who were younger than 45 years, and group II who were 45 years old or older. The mean tumor size and incidences of neck lymph nodes involvement of group I was larger than group II. In group II, however, there were more patients who had multiple cancer foci and were body mass index ≥ 25 kg/m2. The overall incidence of recurrent disease was 3.2%. The incidence of recurrence was higher in group II (2.0% vs. 4.0%), without a statistical difference. In multivariate analysis, the significant risk factors of recurrence were male gender and multifocality in group I, and lymph node metastasis and multifocality in group II. In particular, the male gender and multifocality showed the highest odds ratio (OR) on each group (OR, 4.721 and 6.177).ConclusionThe patients with PTMCs had different clinical features and prognostic factors according to age. Hence, clinicians should consider a different strategy for therapy and plan for follow-up according to age.

Increase of papillary thyroid microcarcinoma and a plea for restrictive treatment: A retrospective study of 1,391 prospective documented patients

“…Recurrence rates, as reported in the literature, range from 0.94% up to 10.3%. [4][5][6]12,28,[32][33][34][38][39][40][41][42] The recurrence rate we observed is even lower at 0.5%, and the recurrent disease was found after a median of 2.4 years. Fatal outcomes from PMCs are observed even less frequently and a literature review indicates that these lie between 0% and 1%.…”

“…Multifocality is found in approximately 20-40% of the PMCs. 4,5,31,32 Our study revealed a multifocal disease in 27.5% of the patients; however, not all of our patients received radical surgery; therefore, the actual rate of multifocality could not be fully evaluated. Multifocality is generally perceived as a risk factor for lymph node metastases and disease recurrence; but there is a lack of evidence-based data to confirm this assumption.…”

Clinicopathologic Characteristics of Papillary Microcarcinoma in the Elderly

“…28) Multifocality in PTMC is not unusual. 17) In this study, the incidence of multifocality was 24.8%. The incidence of multifocality in PTMC has been reported to be 19 to 32%.…”

Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid

“…Selain goiter yang bersifat endemik, sebagian kasus goiter yang terjadi di Indonesia bersifat non endemik. Hal ini sangat berbeda dengan insiden karsinoma tiroid di dunia barat yang lebih sering berkaitan dengan efek radiasi [16,17] Klasifikasi Goiter Secara Klinis…”