Clinical Features and Risk Factors of Pulmonary Hypertension in Chinese Patients With Systemic Lupus Erythematosus

Chen, Xiangfang

doi:10.5606/archrheumatol.2019.6780

Cited by 7 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our ndings were consistent with previous studies. In a study involving 41 SLE patients with PAH and 106 SLE patients without PAH, serositis, Raynaud's phenomenon, anticardiolipin antibodies, and anti-U1RNP were associated with higher risk of SLE-PAH [15]. In another cross-sectional study, Raynaud's phenomenon was associated with elevated pulmonary artery systolic pressure [20].…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus

Zhang

Feng

et al. 2021

Cardiol Young

View full text Add to dashboard Cite

Objectives: Pulmonary arterial hypertension symptoms in systemic lupus erythematosus patients are non-specific and early diagnosis and intervention are challenging. It remains essential to explore risk factors for pulmonary arterial hypertension in systemic lupus erythematosus patients to identify high risk patients and allow intensive monitoring. Methods: From January 2010 to December 2018, 84 patients with systemic lupus erythematosus and pulmonary arterial hypertension and 160 patients with systemic lupus erythematosus but without pulmonary arterial hypertension were enrolled. Clinical manifestations and laboratory test results were compared between the two groups to identify predictors of pulmonary arterial hypertension. Candidate pulmonary arterial hypertension risk factors were further compared among systemic lupus erythematosus-pulmonary arterial hypertension patients with different characteristics. Results: Among collected patient characteristics, Raynaud’s phenomenon (OR 2.32, 95% CI: 1.17–4.61), digital vasculitis (OR 4.12, 95% CI: 1.48–11.49), pericardial effusion, pulmonary interstitial lesions, positive anti-u1 ribonucleoprotein antibodies, and positive anticardiolipin antibodies immunoglobulin G were associated with significantly higher risk of pulmonary arterial hypertension in systemic lupus erythematosus patients. Among these candidate risk factors, positive anti-u1 ribonucleoprotein antibody was independently associated with severe pulmonary arterial hypertension and more active disease. Digital vasculitis was independently associated with systemic lupus erythematosus alleviation, while pericardial effusion was associated with systemic lupus erythematosus deterioration. Pericardial effusion was associated with longer pulmonary arterial hypertension duration. Conclusion: The significant association between studied clinical and laboratory indicators and risk of pulmonary arterial hypertension, pulmonary arterial hypertension and systemic lupus erythematosus characteristics suggested that these factors can be used to identify patients at higher risk of pulmonary arterial hypertension and adverse outcomes. Close monitoring may be indicated in patients with these risk factors, especially with more than one risk factor.

show abstract

Section: Discussionmentioning

confidence: 96%

“…Early diagnosis and intervention are essential to improve patient outcomes. Some clinical manifestations and immunologic test have been shown to predict PAH in SLE patients [14,15]. However, PAH is a complex condition, risk factors may have different association for certain disease characteristics.…”

Section: Introductionmentioning

confidence: 99%

Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus

Zhang

Feng

et al. 2021

Cardiol Young

View full text Add to dashboard Cite

show abstract

“…After removing duplicates, 24 literature were finally screened by looking at titles and abstracts and full text. [3–26] The guidelines flow diagram of literature screening is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Risk factors of systemic lupus erythematosus patients with pulmonary arterial hypertension: A systematic review and meta-analysis

Lun,

Yang,

Liu

et al. 2023

Medicine

View full text Add to dashboard Cite

Background: To investigate the risk factors for the development of pulmonary arterial hypertension (PAH) in patients with systemic lupus erythematosus (SLE). Methods: The literature related to risk factors for the development of PAH in SLE patients was searched by the computer on China national knowledge infrastructure (CNKI), PubMed, and Embase, and the literature search was limited to the period of library construction to October 2022. Two researchers independently performed literature screening and literature information extracting, including first author, publication time, case collection time, sample size, and study factors, and used the Newcastle-Ottawa Scale (NOS) to evaluate the quality of the literature. The relationship between each clinical manifestation and laboratory index and the occurrence of PAH in SLE patients was evaluated based on the ratio (OR value) and its 95% CI. Results: A total of 24 publications were included, including 23 case-control studies and 1 cohort study with NOS ≥ 6, and the overall quality of the literature was high. The risk of PAH was higher in SLE patients who developed Raynaud phenomenon than in those who did not [OR = 2.39, 95% CI (1.91, 2.99), P < .05]; the risk of PAH was higher in SLE patients who were positive for anti-RNP antibodies than in those who were negative for anti-RNP antibodies [OR = 1.77, 95% CI (1.17, 3.2.65), P < .05]; the risk of PAH was higher in SLE patients with interstitial lung lesions than in those without combined interstitial lung lesions [OR = 3.28, 95% CI (2.37, 4.53), P < .05]; the risk of PAH was higher in SLE patients with combined serositis than in those without serositis [OR = 2.28, 95% CI (1.83, 2.84), P < .05]. The risk of PAH was higher in SLE patients with combined pericardial effusion than in those without pericardial effusion [OR = 2.97, 95% CI (2.37, 3.72), P < .05]; the risk of PAH was higher in SLE patients with combined vasculitis than in those without vasculitis [OR = 1.50, 95% CI (1.08, 2.07), P < .05]; rheumatoid factor-positive SLE patients had a higher risk of PAH than those with rheumatoid factor-negative [OR = 1.66, 95% CI (1.24, 2.24), P < .05]. Conclusion: Raynaud phenomenon, vasculitis, anti-RNP antibodies, serositis, interstitial lung lesions, rheumatoid factor, and pericardial effusion are risk factors for the development of PAH in patients with SLE.

show abstract

“…Interestingly, positive anti-U1 ribonucleoprotein had an independent correlation with PH severity, while pericardial effusion was associated with a longer duration of PH and worse prognosis. Additional risk factors of PH development have been proposed by several other studies [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Epidemiology and Classification Of Pah In Sle Patientsmentioning

confidence: 98%

Systemic Lupus Erythematosus and Pulmonary Hypertension

Parperis

Velidakis

Khattab

et al. 2023

IJMS

View full text Add to dashboard Cite

Pulmonary Hypertension (PH) is a common manifestation in patients with Systemic Lupus Erythematosus (SLE) and varies from asymptomatic to life-threatening disease. PH can result not only from immune system dysregulation, but also from various conditions, including cardiorespiratory disorders and thromboembolic diseases. Most commonly, SLE-related PH presents with non-specific symptoms, such as progressive dyspnea on exertion, generalized fatigue and weakness and eventually dyspnea at rest. Prompt diagnosis of SLE-related PH and early identification of the underlying pathogenetic mechanisms is demanded in order to introduce targeted therapy to prevent irreversible pulmonary vascular damage. In most cases the management of PH in SLE patients is similar to idiopathic pulmonary arterial hypertension (PAH). Furthermore, specific diagnostic tools like biomarkers or screening protocols, to establish early diagnosis seem to be not available yet. Although, the survival rates for patients with SLE-related PH vary between studies, it is evident that PH presence negatively affects the survival of SLE patients.

show abstract

Clinical Features and Risk Factors of Pulmonary Hypertension in Chinese Patients With Systemic Lupus Erythematosus

Cited by 7 publications

References 30 publications

Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus

Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus

Risk factors of systemic lupus erythematosus patients with pulmonary arterial hypertension: A systematic review and meta-analysis

Systemic Lupus Erythematosus and Pulmonary Hypertension

Contact Info

Product

Resources

About