Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in <i>Babesia</i>-infected calves

Salem, Noha Y.; Yehia, Shimaa G.; Farag, Heba; Elkhiat, Mohammed Awny

doi:10.1016/j.ijvsm.2016.10.003

Cited by 30 publications

(18 citation statements)

References 29 publications

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“…This significant rise of MAD associated with clinical babesiosis pointed to excessive lipid peroxidation with oxidative cellular damage in affected animals during disease course. Similar findings have been reported in previous studies (Saleh, 2009;Salem et al, 2016;Kumar et al, 2019).…”

Section: Lipid Peroxidation and Antioxidant Capacitysupporting

confidence: 93%

“…The TAC represents the aggregate status of all antioxidants. The results revealed significantly decreased TAC in affected cows in comparison with controls that might be attributed to depletion of antioxidants during neutralization of excessive reactive species generated during course of clinical babesiosis in affected group (Salem et al, 2016;Kumar et al, 2019). The significant rise in lipid peroxidation with reduction of the total antioxidant status in diseased animals in this study proved that babesiosis affected cows experienced severe oxidative stress during disease course.…”

Section: Lipid Peroxidation and Antioxidant Capacitymentioning

confidence: 92%

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Oxidative Stress, Hemogram, Hepatorenal Function Evaluation and Molecular Diagnosis of Babesiosis in Crossbred Cows Naturally Infected with B. bigemina

Abdel-Hamied¹,

Arafa²,

Mahmoud³

2020

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B ovine babesiosis is considered one of the most economically important and serious tick-borne disease affecting cattle especially in the tropical and subtropical regions (Jongejan and Uilenberg, 1994). Haemoprotozoan diseases gain their importance due to the severe economic losses and the harmful effects on the immune status of the affected animals (Urquhart et al., 1996). Babesiosis is caused by an intra-erythrocytic haemoprotozoan attacks susceptible animal red blood cells (Zintl et al., 2003). In Egypt, bovine babesiosis is mainly caused by Babesia bigemina and B. bovis species (Adham et al., 2009; Mahmoud et al., 2015). Inappetence, Fever, hemolytic anemia, icterus, emaciation and hemoglobinuria are the most observed clinical findings in cattle with babesiosis.

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Section: Lipid Peroxidation and Antioxidant Capacitysupporting

confidence: 93%

Section: Lipid Peroxidation and Antioxidant Capacitymentioning

confidence: 92%

Oxidative Stress, Hemogram, Hepatorenal Function Evaluation and Molecular Diagnosis of Babesiosis in Crossbred Cows Naturally Infected with B. bigemina

Abdel-Hamied¹,

Arafa²,

Mahmoud³

2020

AAVS

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“…The previous research studies consistently report similar findings [ 29 - 33 ]. MDA is produced from polyunsaturated fatty acid peroxidation and is used as an indicator for lipid peroxidation [ 34 , 35 ]. A significant mobilization of NEFA in dairy cows associated with increase in free oxygen radicals (e.g., ROS) production [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of parity on metabolic and oxidative stress profiles in Holstein dairy cows

et al. 2020

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Background and Aim: Pregnancy and lactation have an impact on health status of animals and constitute burden on body metabolites and the oxidant-antioxidant equilibrium. This study is aimed at evaluating metabolic and oxidative stress patterns and parity impacts in both primiparous and multiparous dairy cows. Materials and Methods: Twenty-seven primiparous and multiparous Holstein cows were enrolled and categorized into four groups according to their physiologic status: Primiparous peripartum heifer (n=5), primiparous postpartum cow (n=9), multiparous peripartum cows (n=5), and multiparous postpartum cows (n=8). Blood sample was taken from each animal – peripartum groups at 3 weeks prepartum and postpartum groups at 3 weeks post-parturition – for complete blood picture, glucose, cholesterol, triglyceride, total protein, albumin, non-esterified fatty acids (NEFA), malondialdehyde (MDA), total antioxidant capacity, and haptoglobin estimation. Results: Postpartum primiparous cows showed significant decrease in glucose, total protein, and albumin while showing significant increase in MDA, NEFA, and globulin; on the other hand, multiparous postpartum cows showed significant decrease in glucose, total protein, and albumin, associated with significant increase in cholesterol and MDA when compared with prepartum PP and MP cows, respectively. Postpartum multiparous cows significantly showed reduction in NEFA when compared to primiparous postpartum cows. Hematologic profiles of postpartum primiparous and multiparous cows showed significant decrease in red blood cells and packed cell volume, significant increase in lymphocytes when compared with prepartum cows. Conclusion: Metabolic and oxidative abnormalities exist in both primiparous and multiparous cows during the transition phase, however postpartum primiparous cows show higher susceptibility to negative energy balance impacts. Oxidant/ antioxidant imbalance occurred in both the primiparous and multiparous postpartum cows, highlighting the importance of oxidative stress profiles in the assessment of metabolic health status during transition.

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“…These results are consistent with the previous study that indicates that elevated serum globulin level in the A. marginale infected animals could be due to activation of a defensive immune response that leads to an increase in circulating immunoglobulin in the serum [ 28 ]. In contrast, hypoalbuminemia is also reported that could be due to disruption in liver function that leads to a decrease in albumin synthesis during Babesia infection [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Bovine babesiosis is an important tick-borne disease worldwide, but mainly in tropical and subtropical regions. In Egypt, the disease is caused by Babesia bovis and B. bigemina [ 9 ]. B. bovis is an apicomplexan protozoon that parasitizes red blood cells.…”

Section: Introductionmentioning

confidence: 99%

Molecular diagnosis and biochemical studies of tick-borne diseases (anaplasmosis and babesiosis) in Aberdeen Angus Cattle in New Valley, Egypt

et al. 2020

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Background and Aim: Anaplasmosis and babesiosis are tick-borne diseases that threaten livestock production with subsequent considerable economic losses. This study was conducted to diagnose Anaplasma and Babesia infection using molecular techniques in imported Aberdeen Angus cattle imported from Uruguay to El-Kharga Oasis in New Valley, Egypt, and to investigate the effects of disease on some serum biochemical and oxidative stress parameters. Materials and Methods: Blood samples were collected from 31 cattle, 21 diseased and ten apparently normal, of varying ages and sex. The blood was used for the preparation of blood smears, polymerase chain reaction assay, and separation of serum for biochemical investigation. The experimental production farm at the Faculty of Agriculture, New Valley University, was infested with ticks and variable clinical manifestations during the period from December 2017 to March 2018. One calf died of a suspected blood parasite infection. Results: The blood film examination revealed infection by blood parasites in 21 samples. Anaplasma marginale and Babesia bovis were identified in 12 and 14 samples, respectively. A total of 14 samples were examined by polymerase chain reaction (PCR) to make these identifications. Biochemical parameters showed significantly elevated serum alanine aminotransferase, aspartate aminotransferase, total bilirubin (T. Bil), and urea in blood from parasite-infected female cattle and male calves compared with controls. Increased serum total protein, globulin, and creatinine were recorded only in infected female cattle. The blood glucose level was significantly decreased in infected female cattle and male calves compared with controls. Furthermore, albumin and albumin/globulin ratio was significantly reduced in the infected female cattle. Oxidative stress profiles of infected animals showed a significant increase in serum nitric oxide and malondialdehyde, and both total antioxidant capacity and reduced glutathione (GSH) were significantly reduced in comparison with control animals. Conclusion: The incidence of A. marginale and B. bovis infection is high in imported Aberdeen Angus cattle in New Valley Province. PCR methods provide a short-term assessment of disease. An extensive epidemiological survey, employing serology together with molecular genetic methods, monitoring of abundance and distribution of tick vectors, availability of vaccination programs, and tracking of animal transport is also needed for control of blood parasites.

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Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves

Cited by 30 publications

References 29 publications

Oxidative Stress, Hemogram, Hepatorenal Function Evaluation and Molecular Diagnosis of Babesiosis in Crossbred Cows Naturally Infected with B. bigemina

Oxidative Stress, Hemogram, Hepatorenal Function Evaluation and Molecular Diagnosis of Babesiosis in Crossbred Cows Naturally Infected with B. bigemina

Effect of parity on metabolic and oxidative stress profiles in Holstein dairy cows

Molecular diagnosis and biochemical studies of tick-borne diseases (anaplasmosis and babesiosis) in Aberdeen Angus Cattle in New Valley, Egypt

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