Clinical Imaging with Skeletal, Chest, and AbdomenPattern Differentials

Pringle, R.Kevin

doi:10.1016/s0161-4754(99)70013-8

Cited by 1 publication

(3 citation statements)

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“…[3] Bones ensure high tensile and compressive strength but also give elasticity. [4] Another bone function is related to storage as they offer a storehouse of calcium, phosphorus, and other minerals. [4] It is frequently defined as a composite material, with organic and inorganic constituents, with calcium phosphate apatite nanocrystals (hydroxyapatite) inserted in the collagen matrix.…”

Section: Introductionmentioning

confidence: 99%

“…[4] Another bone function is related to storage as they offer a storehouse of calcium, phosphorus, and other minerals. [4] It is frequently defined as a composite material, with organic and inorganic constituents, with calcium phosphate apatite nanocrystals (hydroxyapatite) inserted in the collagen matrix. [5] It is a very dynamic and metabolically active living entity, with its specific vascular supply and innervation, [3] being also exceptionally lightweight and a robust tissue.…”

Section: Introductionmentioning

confidence: 99%

“…[5] It is a very dynamic and metabolically active living entity, with its specific vascular supply and innervation, [3] being also exceptionally lightweight and a robust tissue. [4] The process of bone growth, or bone remodeling/ metabolism, occurs through a lifetime and with different rates, comprising removing and replacing old with new bone tissue, respectively. [5b] Thus, there is controlled synchronization between bone-building cells and bone-resorbing cells, namely, the removal of mineralized bone by osteoclasts, accompanied by bone matrix's growth by osteoblasts, which later become mineralized.…”

Section: Introductionmentioning

confidence: 99%

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Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review

et al. 2022

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Osteoarthritis (OA) is a progressive degenerative disease that causes severe pain and functional limitation, especially during locomotion. It is the most common arthritis type that damages the surface of articular cartilage until the underlying bone. In the past decade, the scientific community has made a considerable effort to improve or discover therapeutical products used as a form of conservative treatment capable of restoring the damaged articular tissue, avoiding, as far as possible, the use of surgical practices. The most common and direct nonoperative application available for OA treatment is the viscosupplementation (VS) procedure that demonstrates a safe, effective method and is less painful for the patients. The most recent works dealing with the design, development, and validation of viscosupplement products in preclinical and clinical trials for OA treatment are overviewed herein. In general, despite the development of new products, hyaluronic acid continues to be among the most reported intra‐articular viscosupplement products used in clinical trials, typically used as an isolated product or conjugated with other biologicals or drugs, such as platelet‐rich plasma and corticosteroids (CS). However, this issue is still demanding innovation. Approaches comprising new biomaterials as VS products, with intrinsic bioactivity, economical, and environmental friendliness, are required.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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