Clinical Impact of Muscle Quantity and Quality in Colorectal Cancer Patients: A Propensity Score Matching Analysis

Okugawa, Yoshinaga; Toiyama, Yuji; Yamamoto, Akira; Shigemori, Tsunehiko; Yin, Chengzeng; Narumi, Aya; Omura, Yusuke; Ide, Shozo; Kitajima, Takahito; Fujikawa, Hiroyuki; Yasuda, Hiromi; Hiro, Junichiro; Yoshiyama, Shigeyuki; Kobayashi, Minàko; Araki, Toshimitsu; Miki, Chikao; Kusunoki, Masato

doi:10.1002/jpen.1171

Cited by 43 publications

(62 citation statements)

References 37 publications

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“…Further information is described in the Supplementary Materials and Methods. Furthermore, low PMI (myopenia) and high IMAC (myosteatosis) occurred more readily in female patients than in male patients, as previously described …”

Section: Methodssupporting

confidence: 74%

“…Furthermore, low PMI (myopenia) and high IMAC (myosteatosis) occurred more readily in female patients than in male patients, as previously described. 22…”

Section: Image Analysismentioning

confidence: 99%

“…To date, our research group has shown that several preoperative markers reflecting SIR, including CRP, NLR, PLR, and modified Glasgow‐prognostic scale, could be used as predictive biomarkers for postoperative morbidity and mortality in patients with CRC . Furthermore, a recent our study revealed the potential of prognostic markers for quantifying skeletal muscle mass in patients with CRC . However, several points still remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Okugawa

Toiyama

Yamamoto

et al. 2018

J Parenter Enteral Nutr

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Background The systemic inflammatory response (SIR) via host‐tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression of cancer cachexia. The objective of this study was to clarify the correlation between sarcopenia and SIR in patients with colorectal cancer (CRC). Methods A total of 308 patients with CRC were enrolled in this study. Preoperative psoas muscle mass index and intramuscular adipose tissue content were evaluated using preoperative computed tomographic images, and the correlation between body composition status and several SIR markers, including C‐reactive protein (CRP), serum albumin level, neutrophil‐lymphocyte ratio, platelet‐lymphocyte ratio, and systemic immune‐inflammation index (SII) was assessed using statistical methods. Results Whereas preoperative myosteatosis was not correlated with clinicopathological factors except for aging and the presence of lymphovascular invasion, preoperative myopenia was significantly associated with well‐established clinicopathological factors. Furthermore, the presence of myopenia was significantly correlated with elevated CRP, SII, and neutrophil‐platelet score, and decreased lymphocyte‐monocyte ratio, prognostic nutrition index, and serum albumin level. Logistic regression analysis revealed that an elevated CRP concentration was an independent risk factor for the presence of preoperative myopenia (odds ratio [OR] 2.49, 95% CI: 1.31–4.72; P = .005). Furthermore, these findings were validated using propensity score matching analysis (OR 2.35, 95% CI: 1.17–4.75; P = .017). Conclusion Quantification of preoperative CRP could identify patients at high risk for development of myopenia who will likely require individualized treatment plans, including postoperative nutrition intervention, rehabilitation, and oncological follow‐up in patients with CRC.

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Section: Methodssupporting

confidence: 74%

“…Furthermore, low PMI (myopenia) and high IMAC (myosteatosis) occurred more readily in female patients than in male patients, as previously described. 22…”

Section: Image Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Okugawa

Toiyama

Yamamoto

et al. 2018

J Parenter Enteral Nutr

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“…A high prevalence of sarcopenia in metastatic cancer patients is well documented. 13,26 Although several factors, such as anorexia due to organ dysfunction by distant metastasis, adverse effect of systemic chemotherapy, deterioration of physical activity, and psychological factors for disease development, can induce sarcopenia in patients, emerging evidence has suggested that sarcopenia may develop because of secretory products from metastatic tissues in various malignancies. 10, 44 Waning and co-workers established seven different mouse models of human osteolytic bone metastases and reported impaired muscle dysfunction in these mice.…”

Section: Discussionmentioning

confidence: 99%

“…Pre‐operative CT scan images were stored in an electronic format suitable for image analysis to assess the BC status. Using pre‐operative plain CT at superior aspect of the fourth lumbar vertebra as previously described, we measured the cross‐sectional area of the bilateral psoas muscles by manual tracing, and then the psoas muscle mass index (PMI) was calculated as follows: PMI = cross‐sectional area of bilateral psoas muscle∕height 2 (cm 2 /m 2 ). Low PMI was regarded as a proxy for low muscle volume, as previously described .…”

Section: Methodsmentioning

confidence: 99%

Circulating miR‐203 derived from metastatic tissues promotes myopenia in colorectal cancer patients

Okugawa

Toiyama

Hur

et al. 2019

J cachexia sarcopenia muscle

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Background Sarcopenia frequently occurs in metastatic cancer patients. Emerging evidence has revealed that various secretory products from metastatic tumours can influence host organs and promote sarcopenia in patients with malignancies. Furthermore, the biological functions of microRNAs in cell‐to‐cell communication by incorporating into neighbouring or distal cells, which have been gradually elucidated in various diseases, including sarcopenia, have been elucidated. Methods We evaluated psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC) using pre‐operative computed tomography imaging in 183 colorectal cancer (CRC) patients. miR‐203 expression levels in CRC tissues and pre‐operative serum were evaluated using quantitative polymerase chain reaction. Functional analysis of miR‐203 overexpression was investigated in human skeletal muscle cells (SkMCs), and cells were analysed for proliferation and apoptosis. Expressions of several putative miR‐203 target genes (CASP3, CASP10, BIRC5, BMI1, BIRC2, and BIRC3) in SKMCs were validated. Results A total of 183 patients (108 men and 75 women) were included. The median age of enrolled patients at diagnosis was 68.0 years (range 35–89 years). High IMAC status significantly correlated with female gender ( P = 0.004) and older age ( P = 0.0003); however, no other clinicopathological factors correlated with IMAC status in CRC patients. In contrast, decreased PMI significantly correlated with female gender ( P = 0.006) and all well‐established disease development factors, including advanced T stage ( P = 0.035), presence of venous invasion ( P = 0.034), lymphovascular invasion ( P = 0.012), lymph node ( P = 0.001), distant metastasis ( P = 0.002), and advanced Union for International Cancer Control tumour–node–metastasis stage classification ( P = 0.0004). Although both high IMAC status and low PMI status significantly correlated with poor overall survival (IMAC: P = 0.0002; PMI: P < 0.0001; log‐rank test) and disease‐free survival (IMAC: P = 0.0003; PMI: P = 0.0002; log‐rank test), multivariate Cox's regression analysis revealed that low PMI was an independent prognostic factor for both overall survival (hazard ratio: 4.69, 95% confidence interval (CI): 2.19–10, P = 0.0001) and disease‐free survival (hazard ratio: 2.33, 95% CI: 1.14–4.77, P = 0.021) in CRC patients. Serum miR‐203 expression negatively correlated with pre‐operative PMI level ( P = 0.0001, ρ = −0.25), and multivariate logistic regression ana...

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Skeletal Muscle Changes Assessed by Preoperative Computed Tomography Images Can Predict the Long‐Term Prognosis of Stage III Colorectal Cancer

Yokoi

Tanaka

Kojo

et al. 2021

Annals of Gastroent Surgery

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Clinical Impact of Muscle Quantity and Quality in Colorectal Cancer Patients: A Propensity Score Matching Analysis

Abstract: Preoperative myopenia could be useful for perioperative management, and quantification of preoperative skeletal muscle mass could identify patients as a high risk for perioperative and oncological outcomes in CRC patients.

Cited by 43 publications

References 37 publications

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis

Circulating miR‐203 derived from metastatic tissues promotes myopenia in colorectal cancer patients

Skeletal Muscle Changes Assessed by Preoperative Computed Tomography Images Can Predict the Long‐Term Prognosis of Stage III Colorectal Cancer

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