Clinical Improvement by Increased Frequency of on-Line Hemodialfiltration

Lin, Che-Kai; Huang, Chiu‐Ching; Chang, Ching-Tung; Wu, Mai-Szu; Hung, Cheng-Chieh; Chien, Chu‐Chun; Yang, Chih‐Wei

doi:10.1081/jdi-100103491

Cited by 48 publications

(38 citation statements)

References 20 publications

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“…But, this study included a small number of patients (about twenty per group). Lin (2001) showed that patients on HDF (online post dilution) had significantly higher physical well-being score compared with high-flux HD. In this study, patients scored their physical conditions such as subjective well-being, work tolerance, and mental alertness weekly.…”

Section: Discussionmentioning

confidence: 99%

“…All patients are dialyzed on biocompatible polysulfone membrane. 20 Also, Schiffl 21 found that HDF was associated with partial improvement of quality of life. Additional tests also showed that there were no statistically significant differences in SF-36 domains between high-flux HD and low-flux HD in our sample.…”

Section: Discussionmentioning

confidence: 99%

“…12,13,19,20 In certain studies, patients on HDF had better quality of life, 20 but in other, there were no significant difference.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 The results of previous studies that evaluated the possible clinical advantages of HDF in comparison with HD are not consistent, and it is not possible to make any precise conclusion out of them. [17][18][19][20][21] Compared with low-flux dialysis, high-flux HD might have a beneficial effect on mortality and clinical outcomes in the patients [22][23][24][25][26][27] or not. 28 The use of synthetic high-flux membranes should be considered to delay the longterm complication of HD therapy: amyloidosis, hyperphosphatemia, cardiovascular risk, and anemia.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Dialysis Modality and Membrane Flux on Quality of Life in Hemodialysis Patients

Knežević¹,

Djordjević²,

Radovanovic-Velickovic³

et al. 2012

Renal Failure

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Background: The quality of life in patients undergoing hemodialysis is significantly disturbed. There are data that hemodiafiltration (HDF) may be more effective than conventional hemodialysis in the removal of uremic toxins and may reduce frequency and severity of intradialytic and postdialysis adverse symptoms in patients. Also, some researchers suggest advantages of using high-flux membranes compared with low-flux. Objective: The aim of this study was to examine whether hemodialysis modality and membrane flux, independent of membrane biocompatibility, make differences in quality of life in patients. Methods: In our cross-sectional study, we evaluated 124 patients who were divided, based on therapy, into three groups: online HDF, high-flux hemodialysis, and low-flux hemodialysis. Data were collected using the Short Form-36 questionnaire combined with special questionnaire, which included demographic and clinically related questions. Results: Health-related quality of life was better in patients on HDF compared with patients on hemodialysis, especially compared with low-flux hemodialysis patients in most of the scales and in both dimensions: physical component scale and mental component scale. There were no statistically significant differences in Short Form-36 domains between high-flux hemodialysis and low-flux hemodialysis. Conclusion: Our data suggest the potential advantages of HDF with regard to influence on quality of life, which is sufficient to justify further research in prospective and longitudinal study design.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…12,13,19,20 In certain studies, patients on HDF had better quality of life, 20 but in other, there were no significant difference.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Dialysis Modality and Membrane Flux on Quality of Life in Hemodialysis Patients

Knežević¹,

Djordjević²,

Radovanovic-Velickovic³

et al. 2012

Renal Failure

View full text Add to dashboard Cite

show abstract

“…One single-center RCT (n538 in the HDF group) reported better self-reported physical wellbeing compared with high-flux HD using a self-developed HRQOL instrument (15), whereas another single-center randomized trial (n524 in the hemodiafiltration group) reported no difference in physical functioning using the Kidney Disease Questionnaire (16). Considering the findings of this much larger multicenter randomized trial, it seems safe to agree with the authors that HDF is unlikely to improve HRQOL in a substantive manner.…”

mentioning

confidence: 99%