Clinical Manifestations and Imaging Characteristics of Gliomatosis Cerebri with Pathological Confirmation

Zhang, Chunpu; Li, Huaqing; Zhang, Weitao; Liu, Minghui; Pan, Wei

doi:10.7314/apjcp.2014.15.11.4487

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…The prevalence and death rates of CNS tumors (Zhang et al, 2014). Here, we studied the clinicopathological characteristics ,incidence and survival rates of patients with CNS tumors in Yazd, Iran to obtain any relation between patients' tumor type , radiological findings, sex, age , location of tumor, and type of treatment with survival rates.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Findings and Five Year Survival Rates for Patients with Central Nervous System Tumors in Yazd, Iran

Zahir

Vakili²,

Navabii³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Findings and Five Year Survival Rates for Patients with Central Nervous System Tumors in Yazd, Iran

Zahir

Vakili²,

Navabii³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Astrocytoma is the most common primary central nervous system tumor. It is a malignant brain tumor with high genetic susceptibility and carcinogenic environmental factors, accounting for about half of all primary intracranial tumors [1,2]. At present, surgical resection is the first choice for the treatment of glioma.…”

Section: Introductionmentioning

confidence: 99%

Effect Of lentinan on Proliferation and Apoptosis Of human Astrocytoma U251 Cells

Yuan¹,

Li²,

Xi³

et al. 2023

pjp

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Aim of the study is To investigate the effect of lentinan on proliferation and apoptosis of human astrocytoma U251 cells. Lentinan was dissolved in DMEM complete medium to form different concentrations (0, 25, 50, 100, 200, 400, 500, 600 μg/ml). CCK8 was used to detect the effect of lentinan with different concentrations on proliferation of human astrocytoma U251 cells, and the expression of Ki-67 was detected by immunofluorescence. In addition, the effect of different concentrations of lentinan on apoptosis of human astrocytoma U251 cells was detected by flow cytometry. Compared with the blank control group, 50 and 100 μg/ml lentinan significantly promoted proliferation of human astrocytoma U251 cells. When the concentration is more than 100 μg/ml, the cell activity gradually decreases, and the cell activity is the lowest when the concentration is 600 μg/ml. In addition, the low concentration lentinan (25, 50, and 100 μg/ml) had no significant effect on apoptosis of human astrocytoma U251 cells. However, lentinan above 200 μg/ml significantly promoted apoptosis of human astrocytoma U251 cells and had a concentration gradient effect, and the highest apoptosis rate was at 600 μg/ml. Conclusion: Lentinan can effectively inhibit proliferation and promote apoptosis of human astrocytoma U251 cells.

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“…Gliomatosis cerebri has been removed from the most recent 2016 World Health Organization (WHO) classification and is now placed into several diffuse glioma subtypes (2); however, the term is still used widely today. Infiltration throughout the white matter represents the progression of an initial lesion in many cases, but gliomatosis can also present with multifocal tumors (3,4).…”

Section: Introductionmentioning

confidence: 99%

Multimodal neuroimaging of gliomatosis cerebri: a case series of four patients

Bonomi

John

Patel

et al. 2020

Acta Radiologica Open

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In the latest World Health Organization classification of brain tumors, gliomatosis cerebri has been redefined to varying subsets of diffuse gliomas; however, the term is still used to describe gliomas with infiltrative growth into three or more cerebral lobes. These tumors are frequently misdiagnosed and difficult to treat due to their atypical presentation using structural imaging modalities including computed tomography and T1/T2-weighted magnetic resonance imaging (MRI). In this retrospective case series, we compared clinical MRI to amino acid positron emission tomography (PET) to assess the potential value of PET in the assessment of the extent of tumor involvement and in monitoring disease progression. We report the clinical course and serial multimodal imaging findings of four patients. Each patient presented at varying points in disease progression with widespread glioma brain involvement and was evaluated at least once by amino acid PET using alpha-[11C]methyl-L-tryptophan ([11C]-AMT). Increased uptake of [11C]-AMT was detected in a subset of non-enhancing brain lesions and detected tumor invasion before MRI signs of tumor in some regions. Increased uptake of [11C]-AMT was also detected in tumorous regions not detected by perfusion MRI or MR spectroscopy. Metabolic response to treatment was also observed in two patients. Overall, these data are consistent with and expand upon previous reports using other amino acid PET tracers in gliomatosis and show the potential added value of this imaging modality to clinical MRI in the detection and monitoring of these diffusely infiltrative tumors.

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Clinical Manifestations and Imaging Characteristics of Gliomatosis Cerebri with Pathological Confirmation

Cited by 4 publications

References 29 publications

Clinicopathological Findings and Five Year Survival Rates for Patients with Central Nervous System Tumors in Yazd, Iran

Clinicopathological Findings and Five Year Survival Rates for Patients with Central Nervous System Tumors in Yazd, Iran

Effect Of lentinan on Proliferation and Apoptosis Of human Astrocytoma U251 Cells

Multimodal neuroimaging of gliomatosis cerebri: a case series of four patients

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