Clinical monosensitivity to salmon and rainbow trout: a case report

Peñas, Elena; Uberti, Francesca; Baviera, Giuseppe; Lorenzo, Chiara Di; Restani, Patrizia

doi:10.1111/pai.12150

Cited by 6 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The next most diverse antibody should be the Atlantic salmon isoforms, however, the anti-salmon antibodies were surprisingly the least cross-reactive only reacting to 52.5% of species parvalbumin (anti-basa parvalbumin 82.5% and anti-pilchard parvalbumin 80%). These findings are supported by clinical studies where fish allergic patients can be monosensitive to Salmonids (Kuehn et al, 2011;Peñas et al, 2014;Vázquez-Cortés et al, 2012), which could be attributed to salmon parvalbumin having a different IgE epitope at the N-terminal region of parvalbumin (Peñas et al, 2014;Perez-Gordo et al, 2011;. This phenomena may also be occurring for the rabbit antibodies analyzed in this study.…”

Section: Raw Heated Neutral Negative Raw Heated Neutral Negative Raw supporting

confidence: 53%

Immunological cross-reactivity between four distant parvalbumins—Impact on allergen detection and diagnostics

Sharp

Stephen

Kraft

et al. 2015

Molecular Immunology

View full text Add to dashboard Cite

Section: Raw Heated Neutral Negative Raw Heated Neutral Negative Raw supporting

confidence: 53%

Immunological cross-reactivity between four distant parvalbumins—Impact on allergen detection and diagnostics

Sharp

Stephen

Kraft

et al. 2015

Molecular Immunology

View full text Add to dashboard Cite

“…A number of studies showed IgE cross-reactivity based on conserved IgE epitopes on β-parvalbumins from different fish species and these are discussed by Klueber et al (24). In contrast, salmonid fish showed the presence of a species-specific IgE epitope of parvalbumin and the absence of cross-reactivity to other fish (43,44). It is possible that parvalbumins from other fish families also have specific IgE epitopes which may be relevant in mono-or oligo-sensitized patients.…”

Section: Allergen Familiesmentioning

confidence: 99%

Fish Allergy Around the World—Precise Diagnosis to Facilitate Patient Management

et al. 2021

View full text Add to dashboard Cite

The accurate and precise diagnosis of IgE-mediated fish allergy is one of the biggest challenges in allergy diagnostics. A wide range of fish species that belong to evolutionary distant classes are consumed globally. Moreover, each fish species may contain multiple isoforms of a given allergen that often differ in their allergenicity. Recent studies indicated that the cross-reactivity between different fish species is limited in some cases and depends on the evolutionary conservation of the involved allergens. Fish allergens belong to several protein families with different levels of stability to food processing. Additionally, different preparation methods may contribute to specific sensitization patterns to specific fish species and allergens in different geographic regions. Here, we review the challenges and opportunities for improved diagnostic approaches to fish allergy. Current diagnostic shortcomings include the absence of important region-specific fish species in commercial in vitro and in vivo tests as well as the lack of their standardization as has been recently demonstrated for skin prick test solutions. These diagnostic shortcomings may compromise patients' safety by missing some of the relevant species and yielding false negative test results. In contrast, the avoidance of all fish as a common management approach is usually not necessary as many patients may be only sensitized to specific species and allergens. Although food challenges remain the gold standard, other diagnostic approaches are investigated such as the basophil activation test. In the context of molecular allergy diagnosis, we discuss the usefulness of single allergens and raw and heated fish extracts. Recent developments such as allergen microarrays offer the possibility to simultaneously quantify serum IgE specific to multiple allergens and allergen sources. Such multiplex platforms may be used in the future to design diagnostic allergen panels covering evolutionary distant fish species and allergens relevant for particular geographic regions.

show abstract

“…Toutefois, certains patients ne réagissent qu'à une espèce de poissons, suggèrant l'existence d'allergènes (mineurs) spécifiques d'espèces. Peñas et al rapportent le cas d'un enfant italien rapportant trois réac-tions anaphylactiques plus ou moins graves quelques minutes après la consommation de saumon (fumé, grillé) et de truite arc-en-ciel [59]. Entre ces réactions, l'enfant avait parfaitement toléré la consommation de poissons divers, autres que les salmonidés.…”

Section: Diversunclassified

Quoi de neuf en allergologie pédiatrique en 2014 ? Épidémiologie générale, diagnostic (précoce), traitement, anaphylaxie, allergie alimentaire, médicamenteuse et aux venins et salives d’insectes (une revue de la littérature internationale 2014)

Ponvert

2015

Revue Française d'Allergologie

View full text Add to dashboard Cite

Clinical monosensitivity to salmon and rainbow trout: a case report

Cited by 6 publications

References 9 publications

Immunological cross-reactivity between four distant parvalbumins—Impact on allergen detection and diagnostics

Immunological cross-reactivity between four distant parvalbumins—Impact on allergen detection and diagnostics

Fish Allergy Around the World—Precise Diagnosis to Facilitate Patient Management

Quoi de neuf en allergologie pédiatrique en 2014 ? Épidémiologie générale, diagnostic (précoce), traitement, anaphylaxie, allergie alimentaire, médicamenteuse et aux venins et salives d’insectes (une revue de la littérature internationale 2014)

Contact Info

Product

Resources

About