Clinical Observations on a Case of Immunodeficiency and Thymoma (Good's Syndrome) Associated With Chronic Mucocutaneous Candidiasis

Abstract

A 50 year-old woman with immunodeficiency and thymoma (Good's syndrome) associated with chronic muco-cutaneous candidiasis (CMCC) was observed. Immunological treatment with transfer factor (TF), supplements of y-globulin and anti-candidal agents was maintained for six years. Because of the association of pure red cell aplasia in the clinical course, systemic steroid therapy was added to the treatment. Although the patient gradually improved, further immunological therapy was considered to be necessary for the tongue lesions due to candidiasis and the agammaglobulinemia.

Insights from a Case of Good’s Syndrome (Immunodeficiency with Thymoma)

“…The association of thymoma and hypogammaglobulinemia was recognized as having a worse prognosis than other types of hypogammaglobulinemia, since not only bacterial but also viral, fungal and parasitic infections were reported [ 17 , 18 , 19 , 20 , 21 , 22 ]. These were opportunistic infections which very rarely occurred in agammaglobulinemia, pointing to the presence of defects also in the cellular compartment of the immune response, dependent on thymus-derived lymphocytes.…”

Goods Syndrome:report of Case.

“…As in patients with hypogammaglobulinemia, infections are mainly bacterial pyogenic germs. An opportunistic infection Cumpylobacter fetus in septicemic form [3] and mucocutaneous candidiasis [4] however, have been observed.…”