Clinical observations on the use of autogenous vaccine made from cultures of coagulase positive hemolytic staphylococcus aureus.

Goodale, Robert L.; Mangiaracine, Anita B.

doi:10.1288/00005537-195203000-00007

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…До применения антибиотиков аутовакцинацию широко использовали для лечения хронических и повторных инфекций [1,[3][4][5]. Согласно литературным данным, аутовакцинация использовалась для лечения заболеваний кожи и под-кожной клетчатки, костей и суставов, органов пищеварения, половых органов и мочевыводящих путей, системы кровообращения, заболеваний глаз, ушей, респираторных заболеваний и заболеваний пародонта [6].…”

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Autovaccination: Effective Personified Treatment of Chronic Infections (When Antibiotic Therapy Is Powerless)

Minuchin

Gareev²,

Sklyar

et al. 2019

Immun. and Allerg.: Sci. and Pract.

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In this article we review and discuss data of the use and mechanisms of action of autovaccines. The idea of autovaccination is that killed microorganisms could be used not only in prevention, but also in the treatment of infections. Autovaccines are prepared individually from strains of microorganisms isolated from the patient. The pathogens are inactivated and then administered in increasing concentrations. Autogenous vaccines permit treatment of infections caused by bacteria against which no preventive vaccine has been available. Autovaccine therapy has a long history, it have been used since the beginning of the 20th century to treat chronic infections. From the literature is known, that autovaccines have been used for treatment diseases’ of the skin, bones, joints, digestive organs, genitals, periodontal, eye, ears, nose and respiratory system the history of the half-century use of auto vaccines has shown that they may be a promising alternative in the treatment of chronic infections. However from the middle of the 20th century autovaccines have been forgotten because of efficient antibiotic therapies. But now rapid spread of multiresistant bacterial and fungal strains enforces the development of new strategies to combat chronic infections. In view of the variability of the bacterial species, personalized approaches could hold promise for patients with recurrent or chronic infection. Therefore interest to autovaccines returns. Autovaccines have been used to treat ongoing chronic infection but their mechanism of action is still unknown. Recently, the results of several studies have been published that examined the effects of autovaccines on the immune system. But published data are quite inconsistent and incomplete. Therefore further research is required in this area. So clinical studies from the early 1900s and novel autovaccination approaches suggest an alternative strategy to antibiotic therapy.

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Autovaccination: Effective Personified Treatment of Chronic Infections (When Antibiotic Therapy Is Powerless)

Minuchin

Gareev²,

Sklyar

et al. 2019

Immun. and Allerg.: Sci. and Pract.

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Antibody responses in furunculosis patients vaccinated with autologous formalin-killed Staphylococcus aureus

Holtfreter

Jursa-Kulesza

Masiuk

et al. 2011

Eur J Clin Microbiol Infect Dis

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Autologous vaccines (short: autovaccines) have been used since the beginning of the 20th century to treat chronic staphylococcal infections, but their mechanisms of action are still obscure. This prospective pilot study involved four patients with furunculosis who were vaccinated with autologous formalin-killed Staphylococcus aureus cells. Vaccines were individually prepared from the infecting S. aureus strain and repeatedly injected subcutaneously in increasing doses over several months. We characterized the virulence gene repertoire and spa genotype of the infecting and colonising S. aureus strains. Serum antibody responses to secreted and surface-bound bacterial antigens were determined by two-dimensional immunoblotting and flow-cytometry based assays (Luminex®). All patients reported clinical improvement. Molecular characterization showed that all strains isolated from one patient over time belonged to the same S. aureus clone. Already before treatment, there was robust antibody binding to a broad range of staphylococcal antigens. Autovaccination moderately boosted the IgG response to extracellular antigens in two patients, while the antibody response of the other two patients was not affected. Similarly, vaccination moderately enhanced the antibody response against some staphylococcal surface proteins, e.g. ClfA, ClfB, SdrD and SdrE. In summary, autovaccination only slightly boosted the pre-existing serum antibody response, predominantly to bacterial surface antigens.Electronic supplementary materialThe online version of this article (doi:10.1007/s10096-010-1136-3) contains supplementary material, which is available to authorized users.

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I. Preliminary Report

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Clinical observations on the use of autogenous vaccine made from cultures of coagulase positive hemolytic staphylococcus aureus.

Cited by 4 publications

References 3 publications

Autovaccination: Effective Personified Treatment of Chronic Infections (When Antibiotic Therapy Is Powerless)

Autovaccination: Effective Personified Treatment of Chronic Infections (When Antibiotic Therapy Is Powerless)

Antibody responses in furunculosis patients vaccinated with autologous formalin-killed Staphylococcus aureus

I. Preliminary Report

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