Clinical, pathological and serological features of spontaneous canine leptospirosis. An evaluation of the IgM- and IgG-specific ELISA.

Hartman, E.G.; Ingh, T. S. G. A. M. van den; Rothuizen, J.

doi:10.1016/0165-2427(86)90078-4

Cited by 29 publications

(20 citation statements)

References 6 publications

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“…It suggests that the younger animals play a particularly important part in the epidemiology of infection. It confirms other published results [28,29] which showed that younger dogs are more severely affected by leptospirosis than older dogs. However, a different situation was observed for serovars Grippotyphosa and Mozdok for which the risk of infection was greater in older (>10 years) and middle-aged (6-9 .…”

Section: Discussionsupporting

confidence: 95%

Emergence of novelLeptospiraserovars: a need for adjusting vaccination policies for dogs?

et al. 2012

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A total of 855 sera from dogs in Greece were tested for antibodies to strains belonging to the Pomona, Grippotyphosa and Australis serogroups of Leptospira to assess exposure levels to these serogroups, possible associations with clinical disease and to evaluate whether these findings support the inclusion of additional serovars in dog vaccines. Antibodies were detected in 110 (12·9%) dogs. The highest seroprevalence (4·9%) was to the proposed novel serovar Altodouro belonging to the Pomona serogroup. This serovar also showed a statistically significant association with clinical disease. Serovar Bratislava antibodies were found in 3·4% of sera. Consideration should be given to the inclusion of serovars belonging to the Pomona serogroup and serovar Bratislava in future dog vaccines for the Greek market.

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Section: Discussionsupporting

confidence: 95%

Emergence of novelLeptospiraserovars: a need for adjusting vaccination policies for dogs?

et al. 2012

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“…A high IgM in combination with a low IgG titre was diagnostic in 15 dogs in this study. This combination is highly suggestive of an acute infection (Hartmann and others 1986). The IFA is, however, not able to distinguish between different serogroups.…”

Section: Discussionmentioning

confidence: 99%

Canine leptospirosis infections – clinical signs and outcome with different suspectedLeptospiraserogroups (42 cases)

Geisen¹,

Stengel²,

Brem³

et al. 2007

J of Small Animal Practice

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“…There is a report that among ten dogs with natural acute leptospiral infection and concomitant finding of positive IgM and IgG specific antibodies, only two of them survived 12 . The finding of concomitant IgG and IgM presence in acute disease in these dogs suggests either reinfection or a long period elapsed since vaccination.…”

Section: Discussionmentioning

confidence: 99%

Leptospirosis severity may be associated with the intensity of humoral immune response

Abdulkader

Daher

Camargo

et al. 2002

Rev. Inst. Med. trop. S. Paulo

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Leptospirosis severity may be increasing, with pulmonary involvement becoming more frequent. Does this increase result from an intense immune response to leptospire? Notice that renal failure, thrombocytopenia and pulmonary complications are found during the immune phase. Thirty-five hospitalized patients with Weil's disease had 5 blood samples drawn, from the 15th day to the 12th month of symptoms, for ELISA-IgM, -IgG and -IgA specific antibody detection. According their 1st IgG titer, the patients were divided into: group 1 (n = 13) titer > 1:400 (positive) and group 2 (n = 22) titer <=1:400 (negative). Early IgG antibodies in group 1 showed high avidity which may indicate reinfection. Group 1 was older, had worse pulmonary and renal function, and fever for a longer period than group 2. Throughout the study, IgG and IgA titers remained higher in group 1. In conclusion, the severity of Weil's disease may be associated with the intensity of the humoral immune response to leptospire.

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Clinical, pathological and serological features of spontaneous canine leptospirosis. An evaluation of the IgM- and IgG-specific ELISA.

Cited by 29 publications

References 6 publications

Emergence of novelLeptospiraserovars: a need for adjusting vaccination policies for dogs?

Emergence of novelLeptospiraserovars: a need for adjusting vaccination policies for dogs?

Canine leptospirosis infections – clinical signs and outcome with different suspectedLeptospiraserogroups (42 cases)

Leptospirosis severity may be associated with the intensity of humoral immune response

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