Clinical potential and neuroplastic effect of targeted virtual reality based intervention for distal upper limb in post-stroke rehabilitation: a pilot observational study

Nath, Debasish; Singh, Neha; Saini, Megha; Banduni, Onika; Kumar, Nand; Srivastava, M V Padma; Mehndiratta, Amit

doi:10.1080/09638288.2023.2228690

Cited by 5 publications

(1 citation statement)

References 51 publications

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“…scale value [27], 6-minute walking distance [28], and Barthel Index (BI) [29]; and the outcome for safety analysis was the incidence rate (IR) of severe adverse events (SAEs), adverse events (AEs), and instrument defect.…”

Section: Assessmentmentioning

confidence: 99%

Efficacy and safety of using a unilateral lower limb exoskeleton in neurorehabilitation: a randomized controlled trial

Jin,

Zhang,

Chen

et al. 2023

Preprint

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Background Stroke remains the leading cause of both mortality and disability globally. Recovery of limb function in patients with stroke is usually poor and requires an extended period. Consequently, rehabilitation technology in stroke has gained attention. A unilateral lower limb exoskeleton (ULLE), which has an intelligent relearning feature that promotes active engagement of the patient’s brain in controlling of encouraging a patient to actively use their brain to control the unaffected limb to lead the interactive movement of both limbs, thereby achieving individualized bilateral combined functional training, was recently developed to be used in patients with hemiplegia after stroke or traumatic brain injury. However, data on the efficacy and safety of ULLE in patients with stroke are scarce. We aimed to assess the effectiveness and safety of the LiteStepper® ULLE in gait training of patients with post-stroke hemiplegia. Methods This study was a multicenter, optimal, open, loaded, randomized controlled trial. Overall, 92 patients in their post-stroke phase from Hangzhou First People’s Hospital, The Second Affiliated Hospital Zhejiang University School of Medicine, The First Hospital of Jiaxing, and The Fifth Affiliated Hospital of Zhengzhou University were enrolled in this study. The experimental group (EG) adopted the LiteStepper® ULLE based on a once-daily 21-day routine rehabilitation. The conventional group (CG) only underwent the once-daily 21-day routine rehabilitation. Results The efficacy analysis outcomes (Berg balance scale, Functional Ambulation Category scale, 6-minute walking distance, and Barthel Index) between EG and CG had significant differences (P < 0.05) (analyzed using full analysis and per protocol sets). EG showed better improvements than CG (lower limit value [EG-CG] > 2). Safety analysis showed that only one adverse event related to the device occurred during the study, which verified the safety of using the ULLE for gait training in patients after stroke. Conclusions The LiteStepper®ULLE is effective and safe for gait training in patients after stroke. Trial registration ClinicalTrials.gov identifier: NCT05360017

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Section: Assessmentmentioning

confidence: 99%

Efficacy and safety of using a unilateral lower limb exoskeleton in neurorehabilitation: a randomized controlled trial

Jin,

Zhang,

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

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Post-stroke rehabilitation in the peri-pandemic COVID-19 era

Assylbek,

Kocyigit,

Yessirkepov

et al. 2024

Rheumatol Int

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Immersive Virtual Reality Games in Neuromotor Rehabilitation with Brain-Computer Interfaces: A Scoping Review

Gaafer,

Ahmed,

El-Husseiny

et al. 2024

Preprint

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The use of immersive virtual reality (VR) is gaining traction among the scientific community as it opens great opportunities in the field of rehabilitation. By making use of video game mechanics and Brain computer interface (BCI) that is based on electroencephalography (EEG) signals, patients undergoing neurorehabilitation can be more engaged in rehabilitation training. This paper reviews the available literature which uses BCI and VR in game rehabilitation and analyses the gaming elements and brain machine interfaces (BMI) used in each study. Four databases (IEEE Xplore, PubMed, Web of Science, Scopus) from inception until October 2023 were queried using a comprehensive searching strategy and then screened by two independent reviewers. A total of 18 articles were found eligible for qualitative synthesis. These are the main findings: (1) A diverse participant demographic spanned age and health conditions; (2) Oculus Rift has gained prominence as a VR device, replacing older CAVE systems; (3) All surveyed studies unanimously relied on the Motor Imagery (MI) paradigm, reflecting its importance in neuro motor rehabilitation and neuroplasticity; (4) Rehabilitation games displayed varied characteristics, emphasizing scoring, embodiment, and customization. Notably, the lack of gamification elements in some games suggests an area for potential enhancement and future research.

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Clinical potential and neuroplastic effect of targeted virtual reality based intervention for distal upper limb in post-stroke rehabilitation: a pilot observational study

Cited by 5 publications

References 51 publications

Efficacy and safety of using a unilateral lower limb exoskeleton in neurorehabilitation: a randomized controlled trial

Efficacy and safety of using a unilateral lower limb exoskeleton in neurorehabilitation: a randomized controlled trial

Post-stroke rehabilitation in the peri-pandemic COVID-19 era

Immersive Virtual Reality Games in Neuromotor Rehabilitation with Brain-Computer Interfaces: A Scoping Review

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