Clinical Presentation and Risk Factors of Venous Thromboembolic Disease

Alhassan, Sulaiman; Pelinescu, Anca; Gandhi, Viral; Naddour, Mouhib; Singh, Anil; Bihler, Eric

doi:10.1097/cnq.0000000000000159

Cited by 18 publications

(13 citation statements)

References 58 publications

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“…The clinical picture of venous thromboembolism depends on the site of the thrombus, and it can range from asymptomatic to severely symptomatic, but the suspicion of venous thromboembolic event is raised when the patient has an unexplained episode of dyspnea, hypoxia or unilateral leg pain, and swelling [62].…”

Section: Venous Thromboembolismmentioning

confidence: 99%

Cardiovascular Manifestations of Inflammatory Bowel Disease: Pathogenesis, Diagnosis, and Preventive Strategies

Bunu

Timofte²,

Ciocoiu

et al. 2019

Gastroenterology Research and Practice

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Inflammatory bowel disease (IBD) refers to a group of chronic inflammatory diseases that targets mainly the gastrointestinal tract. The clinical presentation of IBD includes both gastrointestinal manifestations and extraintestinal manifestations (EIM). The reported cardiovascular manifestations in IBD patients include pericarditis, myocarditis, venous and arterial thromboembolism, arrhythmias, atrioventricular block, heart failure, endocarditis, valvulopathies, and Takayasu arteritis. The aim of this article is to review the available literature about the possible pathogenic mechanisms and determine preventive measures capable of reducing the incidence and severity of the cardiovascular manifestations. In IBD patients, the incidence of cardiovascular manifestations is low, but higher than that in the general population. Therefore, clinicians should pay attention to any new modification that might indicate cardiovascular involvement in IBD patients, and they should consider chronic inflammatory diseases in patients with cardiac conditions without an evident cause. Considering the role of inflammation in the development of cardiovascular manifestations, the management should include prevention of flares and maintenance of remission for as long as possible. Preventive measures should also include active screening and strict control of the cardiovascular risk factors in all IBD patients.

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Section: Venous Thromboembolismmentioning

confidence: 99%

Cardiovascular Manifestations of Inflammatory Bowel Disease: Pathogenesis, Diagnosis, and Preventive Strategies

Bunu

Timofte²,

Ciocoiu

et al. 2019

Gastroenterology Research and Practice

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“…A diminuição da mobilidade é um fator favorável na tríade de Virchow e contribui de forma significativa para o aumento das taxas de morbimortalidade em gestantes. Gestantes com pré-disposição de TVP devem fazer uso de medidas profiláticas e a deambulação, sempre que possível, deve ser mantida a fim de garantir uma gestação mais segura e saudável (Albassan et al, 2017).…”

Section: Discussionunclassified

Trombose vascular periférica no período gestacional

Oliveira

Sant'anna

Lima

et al. 2020

RSD

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A Trombose Vascular Periférica (TVP) é uma doença caracterizada pelo desenvolvimento de trombos em vasos da periferia, especificamente nos membros inferiores. Categorizar os principais fatores de riscos que levam o surgimento da Trombose Vascular Periférica na gravidez e indicar medidas profiláticas para as possíveis complicações desta da doença. Pesquisa qualitativa, de caráter exploratório e explicativo, com orientação integrativa, mediante a busca de artigos científicos nos bancos de dados NCBI, PUBMED e SCIELO. Analisando os fatores extrínsecos e intrínsecos, diabetes mellitus interage com alguns mecanismos ligados a hemostasia; a obesidade é um fator extrínseco extremamente ligado no desenvolvimento da trombose na gestação; os contraceptivos são medicamentos que aumenta a probabilidade de desenvolver trombos nos vasos; a deficiência da antitrombina I, favorece eventos trombóticos tanto na gestação quanto no puerpério. As medidas profiláticas como heparina de baixo peso molecular (HBPM) um fármaco que interage com a antitrombina aumentando a sua atividade, e as meias de compressão, agem diminuindo a estase venosa. A trombose vascular na gestação está inteiramente ligada a fatores intrínsecos em concomitância com fatores extrínsecos. A HBPM é um medicamento preferível nesse período, bem como as meias de compressão.

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“…It is well known that hypercoagulability and slow blood flow are the basis of thrombosis. 21 With age, increasing clotting activity occurs as a result of increased coagulation factor activity. 22 The blood stasis area of the gastrocnemius muscle side valve is enlarged, blood flow is slow, and DVT forms more readily.…”

Section: Discussionmentioning

confidence: 99%

Risk Assessment in Chinese Hospitalized Patients Comparing the Padua and Caprini Scoring Algorithms

Chen

Pan

Deng

et al. 2018

Clin Appl Thromb Hemost

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The current venous thromboembolism (VTE) guidelines recommend all patients to be assessed for the risk of VTE using risk assessment models (RAMs). The study was to evaluate the performance of the Caprini and Padua RAMs among Chinese hospitalized patients. We reviewed data from 189 patients with deep venous thrombosis (DVT) and 201 non-DVT patients. Deep venous thrombosis risk factors were obtained from all patients. The sensitivity and specificity of the Caprini and Padua scores for all patients were calculated. The receiver operating curve (ROC) and the area under the ROC curve (AUC) were used to evaluate the performance of each score. We documented that age, acute infection, prothrombin time (PT), D-dimer, erythrocyte sedimentation rate, blood platelets, and anticoagulation were significantly associated with the occurrence of DVT ( P < .05). These results were true for all medical and surgical patients group (G1), as well as the analysis of medical versus surgical patients (G2). Finally, analysis of the scores in patients with and without cancer was also done (G3). The Caprini has a higher sensitivity but a lower specificity than the Padua ( P < .05). Caprini has a better predictive ability for the first 2 groups ( P < .05). We found Caprini and Padua scores have a similar predictive value for patients with cancer ( P > .05), while Caprini has a higher predictive ability for no cancer patients in G3 than Padua ( P < .05). For Chinese hospitalized patients, Caprini has a higher sensitivity but a lower specificity than Padua. Overall, Caprini RAM has a better predictive ability than Padua RAM.

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Clinical Presentation and Risk Factors of Venous Thromboembolic Disease

Cited by 18 publications

References 58 publications

Cardiovascular Manifestations of Inflammatory Bowel Disease: Pathogenesis, Diagnosis, and Preventive Strategies

Cardiovascular Manifestations of Inflammatory Bowel Disease: Pathogenesis, Diagnosis, and Preventive Strategies

Trombose vascular periférica no período gestacional

Risk Assessment in Chinese Hospitalized Patients Comparing the Padua and Caprini Scoring Algorithms

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