Clinical Presentation of Complete Hydatidiform Mole and Partial Hydatidiform Mole at a Regional Trophoblastic Disease Center in the United States

Sun, Sue Yazaki; Melamed, Alexander; Joseph, Naima T.; Gockley, Allison; Goldstein, Donald P.; Bernstein, Marilyn R.; Horowitz, Neil S.; Berkowitz, Ross S.

doi:10.1097/igc.0000000000000608

Cited by 38 publications

(30 citation statements)

References 16 publications

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“…Vaginal bleeding was 69% in SA adolescents, which is in agreement with recent studies reporting a 70% rate [24,25]. In a study of NA adolescents conducted from 1970 to 2009 at the NETDC, vaginal bleeding rate was also 70% [5].…”

Section: Discussionsupporting

confidence: 88%

Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia

Soares

Maestá

Colon³

et al. 2016

Gynecologic Oncology

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Section: Discussionsupporting

confidence: 88%

Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia

Soares

Maestá

Colon³

et al. 2016

Gynecologic Oncology

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“…Patients with PHM are less likely to be diagnosed before uterine evacuation, and the diagnosis is usually made with histologic analysis of curettage specimens after incomplete or missed abortion (6,13). As with CHM, the majority of patients with PHM (75%) present with vaginal bleeding; they typically present later than those with CHM (5,13).…”

Section: Molar Pregnancy Clinical Presentationmentioning

confidence: 99%

Gestational Trophoblastic Disease: Clinical and Imaging Features

et al. 2017

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Gestational trophoblastic disease (GTD) is a spectrum of both benign and malignant gestational tumors, including hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The latter four entities are referred to as gestational trophoblastic neoplasia (GTN). These conditions are aggressive with a propensity to widely metastasize. GTN can result in significant morbidity and mortality if left untreated. Early diagnosis of GTD is essential for prompt and successful management while preserving fertility. Initial diagnosis of GTD is based on a multifactorial approach consisting of clinical features, serial quantitative human chorionic gonadotropin (β-hCG) titers, and imaging findings. Ultrasonography (US) is the modality of choice for initial diagnosis of complete hydatidiform mole and can provide an invaluable means of local surveillance after treatment. The performance of US in diagnosing all molar pregnancies is surprisingly poor, predominantly due to the difficulty in differentiating partial hydatidiform mole from nonmolar abortion and retained products of conception. While GTN after a molar pregnancy is usually diagnosed with serial β-hCG titers, imaging plays an important role in evaluation of local extent of disease and systemic surveillance. Imaging also plays a crucial role in detection and management of complications, such as uterine and pulmonary arteriovenous fistulas. Familiarity with the pathogenesis, classification, imaging features, and treatment of these tumors can aid in radiologic diagnosis and guide appropriate management. RSNA, 2017.

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“…[6][7][8] Post-molar surveillance using serum hCG can identify GTN early and allow prompt initiation of chemotherapy. [6][7][8] Post-molar surveillance using serum hCG can identify GTN early and allow prompt initiation of chemotherapy.…”

mentioning

confidence: 99%

“…between 8% and 25%. [6][7][8] Post-molar surveillance using serum hCG can identify GTN early and allow prompt initiation of chemotherapy.…”

mentioning

confidence: 99%

Type I interferons modulate methotrexate resistance in gestational trophoblastic neoplasia

Elias

Harvey

Hasselblatt

et al. 2017

American J Rep Immunol

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Clinical Presentation of Complete Hydatidiform Mole and Partial Hydatidiform Mole at a Regional Trophoblastic Disease Center in the United States

Abstract: This study indicates that, at our center over the past 20 years, both CM and PM were usually evacuated in the first trimester of pregnancy. Because CM more commonly presents with the signs and symptoms of molar disease than PM, CM is more commonly diagnosed prior to evacuation.

Cited by 38 publications

References 16 publications

Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia

Complete molar pregnancy in adolescents from North and South America: Clinical presentation and risk of gestational trophoblastic neoplasia

Gestational Trophoblastic Disease: Clinical and Imaging Features

Type I interferons modulate methotrexate resistance in gestational trophoblastic neoplasia

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