Clinical Profile of Surgical Diseases with Emergence of New Problems in HIV+ Individuals

Vallabha, Tejaswini; Dhamangaonkar, Mandar; Sindgikar, Vikram; Nidoni, Ravindra; Biradar, Harshavardhan; Kv, Aniketan; Baloorkar, Ramakanth

doi:10.1007/s12262-015-1417-2

Cited by 3 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are in keeping with previous studies that have investigated the effect of HIV on appendicitis (5)(6)(7)(8). In spite of these correlations, the impact of the HIV pandemic on surgical outcomes remains controversial; there are no prospective trials in the current literatureand most retrospective studies are small and yielded conflicting results (1,(22)(23)(24). Early reports showed high mortality rates of 55% to 70% in AIDS patients undergoing emergency surgery.…”

Section: Discussionsupporting

confidence: 86%

A Study Comparing Outcomes of Appendectomy between HIV-Infected and HIV-Negative Patients

Sobnach¹,

Ede²,

Linde³

et al. 2019

chr

View full text Add to dashboard Cite

Complicaţiile postoperatorii (44,4% faţă de 17,2%, P = 0,03) şi durata mai lungă a internării în spital (7,28 zile faţă de 5,95 zile, P = 0,004) au fost de asemenea mai frecvent observate la pacienţii cu HIV +. Nu au existat diferenţe în ceea ce priveşte ratele de ruptură ale apendicelui, rezultatele histopatologice şi mortalitatea. Concluzii: Pacienţii HIV+ s-au prezentat mai târziu la spital, iar intervenţia chirurgicală a fost asociată cu o rată mai ridicată a morbidităţii postoperatorii şi o perioadă mai lungă a internării.

show abstract

Section: Discussionsupporting

confidence: 86%

A Study Comparing Outcomes of Appendectomy between HIV-Infected and HIV-Negative Patients

Sobnach¹,

Ede²,

Linde³

et al. 2019

chr

View full text Add to dashboard Cite

show abstract

Analysis of the efficacy of drilling decompression autologous bone marrow and allogeneic bone grafting in the treatment of HIV-positive patients with early osteonecrosis of the femoral head

Li,

Wang,

et al. 2023

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Objective To investigate the efficacy of treating patients with HIV-positive osteonecrosis of the femoral head using drilled decompression autologous bone marrow and allogeneic bone grafting. Methods 40 patients (44 hips) with early osteonecrosis of the femoral head treated by drilling decompression autologous bone marrow and allogeneic bone grafting since October 2015 were retrospectively analyzed, among which 20 patients (24 hips) were HIV-positive patients with early osteonecrosis of the femoral head, 16 males and 4 females, age 22–43 years, average 39.6 ± 10.18 years, and 20 patients (20 hips) in the same period HIV-negative early osteonecrosis of the femoral head patients, 13 males and 7 females, aged 48–78 years, mean 63.50 ± 7.94 years were negative controls. General information including ARCO stage, Harris score, VAS score, hematological indexes including CD4+ T lymphocyte count, and HIV viral load was recorded for all patients before surgery. All patients were operated on by drilling and decompression of the necrotic area, harvesting autologous iliac bone marrow with allogeneic bone, and bone grafting through the decompression channel. The patients were followed up regularly at 6, 12, and 24 months after surgery and annually thereafter, and the repair of the necrotic femoral head was observed by reviewing the frontal and lateral X-ray, CT or MRI of the hip joint, and the complications and functional recovery of the hip joint was counted and compared between the two groups. Results All patients were followed up, and the ARCO stages in the HIV-positive group were stage I 2 hips, stage IIA 6 hips, stage IIB 8 hips, stage IIC 6 hips, and stage III 2 hips, with a follow-up time of 12 to 60 months and a mean of 24.6 months. In the negative control group, there were 3 hips in ARCO stage I, 7 hips in stage IIA, 5 hips in stage IIB, 3 hips in stage IIC, and 2 hips in stage III, and the follow-up time ranged from 13 to 62 months, with an average of 24.8 months. The Harris score and VAS score of the hip in both groups improved significantly at 6 months postoperatively compared with those before surgery (P < 0.001). The difference between the Harris score of the hip in the positive group at 24 months postoperatively compared with that at 6 months postoperatively was statistically significant, but the VAS score at 24 months postoperatively compared with that at 6 months postoperatively was not statistically significant. In the negative group, there was no statistically significant difference in the Harris score and VAS score of the hip at 24 months postoperatively compared with those at 6 months postoperatively. In the positive group, there was a trend of continuous increase in hip BMD from the beginning of the postoperative period (P < 0.001). There was no statistically significant difference between the negative group and the positive group at the 24 months postoperatively follow-up except for the Harris score, which was statistically significant (P < 0.001), and the VAS score, which was statistically insignificant. At the 24 months postoperatively follow-up, patients in both groups had good recovery of hip function, and no complications such as vascular and nerve injury and fracture occurred during the perioperative period and follow-up period, and no complications related to incisional infection and pulmonary infection occurred during hospitalization. Conclusion The treatment of early HIV-positive osteonecrosis of the femoral head patients with autologous bone marrow and allogeneic bone grafting by drilling and decompression to remove the tissue in the necrotic area of the femoral head can effectively stop the process of osteonecrosis of the femoral head and promoting femoral head repair in HIV-positive patients is a safe and effective method for treating HIV-positive patients with early osteonecrosis of the femoral head, and can effectively delay or postpone total hip replacement in patients.

show abstract

Analysis of the efficacy of drilling decompression autologous bone marrow and allogeneic bone grafting in the treatment of HIV-positive patients with early osteonecrosis of the femoral head

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective To investigate the efficacy of treating patients with HIV-positive osteonecrosis of the femoral head using drilled decompression autologous bone marrow and allogeneic bone grafting. Methods 40 patients (44 hips) with early osteonecrosis of the femoral head treated by drilling decompression autologous bone marrow and allogeneic bone grafting since October 2015 were retrospectively analyzed, among which 20 patients (24 hips) were HIV-positive patients with early osteonecrosis of the femoral head, 16 males and 4 females, age 22–43 years, average 39.6 ± 10.18 years, and 20 patients (20 hips) in the same period HIV-negative early osteonecrosis of the femoral head patients, 13 males and 7 females, aged 48–78 years, mean 63.50 ± 7.94 years were negative controls. General information including ARCO stage, Harris score, VAS score, hematological indexes including CD4+ T lymphocyte count, and HIV viral load was recorded for all patients before surgery. All patients were operated on by drilling and decompression of the necrotic area, harvesting autologous iliac bone marrow with allogeneic bone, and bone grafting through the decompression channel. The patients were followed up regularly at 6, 12, and 24 months after surgery and annually thereafter, and the repair of the necrotic femoral head was observed by reviewing the frontal and lateral X-ray, CT or MRI of the hip joint, and the complications and functional recovery of the hip joint was counted and compared between the two groups. Results All patients were followed up, and the ARCO stages in the HIV-positive group were stage I 2 hips, stage IIA 6 hips, stage IIB 8 hips, stage IIC 6 hips, and stage III 2 hips, with a follow-up time of 12 to 60 months and a mean of 24.6 months. In the negative control group, there were 3 hips in ARCO stage I, 7 hips in stage IIA, 5 hips in stage IIB, 3 hips in stage IIC, and 2 hips in stage III, and the follow-up time ranged from 13 to 62 months, with an average of 24.8 months. The Harris score and VAS score of the hip in both groups improved significantly at 6-month after surgery compared with those before surgery (P < 0.05). The difference between the Harris score of the hip in the positive group at 2-year after surgery compared with that at 6-month after surgery was statistically significant, but the VAS score at 2-year after surgery compared with that at 6-month after surgery was not statistically significant. In the negative group, there was no statistically significant difference in the Harris score and VAS score of the hip at 2-year after surgery compared with those at 6-month after surgery. In the positive group, there was a trend of continuous increase in hip BMD from the beginning of the postoperative period (P < 0.05). There was no statistically significant difference between the negative group and the positive group at the 2-year postoperative follow-up except for the Harris score, which was statistically significant (P < 0.05), and the VAS score, which was statistically insignificant (P > 0.05). At the 2-year postoperative follow-up, patients in both groups had good recovery of hip function, and no complications such as vascular and nerve injury and fracture occurred during the perioperative period and follow-up period, and no complications related to incisional infection and pulmonary infection occurred during hospitalization. Conclusion The treatment of early HIV-positive osteonecrosis of the femoral head patients with autologous bone marrow and allogeneic bone grafting by drilling and decompression to remove the tissue in the necrotic area of the femoral head can effectively stop the process of osteonecrosis of the femoral head and promoting femoral head repair in HIV-positive patients is a safe and effective method for treating HIV-positive patients with early osteonecrosis of the femoral head, and can effectively delay or postpone total hip replacement in patients.

show abstract

Clinical Profile of Surgical Diseases with Emergence of New Problems in HIV+ Individuals

Cited by 3 publications

References 11 publications

A Study Comparing Outcomes of Appendectomy between HIV-Infected and HIV-Negative Patients

A Study Comparing Outcomes of Appendectomy between HIV-Infected and HIV-Negative Patients

Analysis of the efficacy of drilling decompression autologous bone marrow and allogeneic bone grafting in the treatment of HIV-positive patients with early osteonecrosis of the femoral head

Analysis of the efficacy of drilling decompression autologous bone marrow and allogeneic bone grafting in the treatment of HIV-positive patients with early osteonecrosis of the femoral head

Contact Info

Product

Resources

About