Clinical relevance of reporting fatty liver on ultrasound in asymptomatic patients during routine health checkups

Mahale, Ajit; Prabhu, Sonali; Nachiappan, Muthiah; Fernandes, Merwyn; Ullal, Sonali

doi:10.1177/0300060518793039

Cited by 29 publications

(24 citation statements)

References 18 publications

(36 reference statements)

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“…6 In their study Mahale et al reported the mean age of 49.73 years. 7 The majority of the cases in our study were in the age group 40 to 60 years. Similar findings were also reported in their study by Khanal et al, where majority of patients belonged to age group of 50-59 (32.1%), followed by 40-49 (28.8%).…”

Section: Discussionmentioning

confidence: 71%

“…But Ultrasound, ALT and AST showed no correlation with fibrosis score. 6 High serum ALT and AST levels were seen in 13.8% and 35.5% cases of NAFLD respectively in their study by Mahale et al 7 However these results were not statistically significant.…”

Section: Discussionmentioning

confidence: 81%

“…Uppalapati et al also reported that females had high risk of developing fatty liver disease in their study. 10 Male and female patients comprised 37.6% and 62.4% of the cases of fatty liver in the study by Mahale et al 7 However Singh et al reported the incidence of fatty liver to be more in males than in females. 11 In our study most of the cases were grade 1 fatty liver.…”

Section: Discussionmentioning

confidence: 95%

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Comparison of liver enzymes and sonological grading in nonalcoholic fatty liver

et al. 2020

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Background: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of diffuse liver disease with a global prevalence of 25.24% and progresses to fibrosis and nonalcoholic steatohepatitis (NASH). Diagnosing NAFLD requires demonstration of increased liver fat and ultrasound imaging is widely used for screening. Specific blood tests to diagnose NAFLD and NASH are not yet available and alanine transaminase (ALT) has been used as a marker in population based studies. Aims and Objective: This study was aimed to compare the liver enzymes and sonological grading in NAFLD. Materials and Methods: A prospective hospital based observational study was carried out in 85 patients presenting to medical outpatient department (OPD) with ultrasonogical evidence of nonalcoholic fatty liver (NAFL) from January 2016 to December 2016. The patients were sent for liver enzymes and serum ALT,aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) were particularly correlated with the grade of NAFL.Data were collected on a preformed proformaand analyzed using the Statistical Package for the Social Sciences (SPSS)20.0 (SPSS Inc., Chicago, IL, USA). Results: In our study, mean age of the patients was 46.08 years and most of the patients were in age group of 40-60 years. Females (65.88%) were more affected than males (34.12%). There were 71 (83.5%) patients with grade 1 NAFL and 14 (16.5%) patients with grade 2 NAFL. The level of serum ALT increased with higher grades of NAFL. The mean ALT in grade 1 NAFL was 29.14±19.41 and in grade 2 NAFL was 42.19±2157; p= 0.027. Comparison of serum AST and GGT with ultrasonological grading did not show statistical difference. Conclusion: Serum ALT levels correlated with the ultrasonological grades of NAFLD (p = 0.027) whereas AST and ALT did not show statistical correlation with grades of fatty liver. Our study suggests for large sample size study for AST and GGT values relationship with ultrasonological grades.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 95%

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Comparison of liver enzymes and sonological grading in nonalcoholic fatty liver

et al. 2020

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“…The prevalence of NAFLD varies widely; it affects approximately 25% of individuals across the globe (7,8). Its relatively high prevalence even in apparently healthy Turkish individuals underlines the importance of early recognition of MAFLD in daily clinical practice (9)(10)(11)(12). Unfortunately, early diagnosis of MAFLD constitutes a major clinical challenge owing to its usually asymptomatic presentation.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Metabolic Associated Fatty Liver Disease in The Turkish Population: A Multicenter Study

Yılmaz¹

2021

Hepatology Forum

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Background and Aim:The aim of the present study was to investigate the prevalence of metabolic associated fatty liver disease (MAFLD) in patients with dyspepsia. Methods:Between January 2019 and December 2019, a total of 909 consecutive patients with complaint of dyspepsia were included.Results: Their median age was 47 years. Among them, 30.3% of the patients were obese, 18.8% had type 2 diabetes mellitus, 35.1% had metabolic syndrome, 84.8% had dyslipidemia, and 23.9% had hypertension.The prevalence of MAFLD was found to be 45.5%. Among those patients with MAFLD prevalence of obesity, type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, and hypertension were 43.3%, 24.9%, 52.5%, 92.3% and 31.9%, respectively. MAFLD was significantly associated with all the metabolic comorbidities (p<0.001). The median FIB-4 score of the MAFLD patients was 0.88 [0.1-9.5]. Of note, 53 patients with hepatic steatosis did not meet the MAFLD criteria.In Conclusion, based on the results of the present study, the prevalence of MAFLD is found to be significantly high in daily clinical practice in Turkey. Early diagnosis and prevention efforts should be aimed to reduce disease progression, which highlight application of a region based implementation strategy in our country.

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“…Studies have shown that metabolic comorbidities interrelated with NAFLD include obesity, type 2 diabetes mellitus (T2DM), hypertension, hyperlipidemia and metabolic syndrome [2]. NAFLD represents a series of diseases ranging from non-alcoholic fatty liver (simple steatosis) thorough non-alcoholic steatohepatitis (NASH) to different stages of brosis, nally cirrhosis hepatocellular carcinoma, and terminal liver failure [7][8][9]. Currently, the obesity epidemic in the world is leading to a sharp increase in NAFLD, which is expected to lead to an increase in clinical and economic burden [10].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Dysregulation of miR-129-5p in Patients with Non-Alcoholic Fatty Liver Disease and Its Regulatory Effect on Insulin Resistance

Zhang

Niu

Liang

et al. 2020

Preprint

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Background: Non-alcoholic fatty liver (NAFLD) is the hepatic manifestation of metabolic syndromes, insulin resistance (IR) is related to the occurrence of NAFLD. The purpose of this study was to evaluate the expression of miR-129-5p in NAFLD patients and its clinical value, and explore its regulatory effect on IR.Methods: 117 NAFLD patients and 110 healthy controls were included. The levels of miR-129-5p were detected by qRT-PCR. To assess the diagnostic value of miR-129-5p for NAFLD, the receiver operating characteristic curve (ROC) was established. C57Bl/6 mice were supplied with high-fat diet to establish NAFLD model. Intraperitoneal insulin tolerance test (IPITT) was carried out to evaluate the effect of miR-129-5p on IR in NAFLD animal model.Results: miR-129-5p was highly expressed in the serum of NAFLD patients, and patients with HOMA-IR ≥ 2.5 had higher level of miR-129-5p than those with HOMA-IR < 2.5. miR-129-5p had the ability to differentiate NAFLD patients from healthy individuals, and might be associated with the development of IR. Serum miR-129-5p was positively correlated with the levels of HOMA-IR, BMI, total cholesterol (TC) and triglyceride (TG) in NAFLD patients. Downregulation of miR-129-5p regulates lipid metabolism and insulin sensitivity in NAFLD mice model.Conclusions: MiR-129-5p was up-regulated in NAFLD patients, and might be a potential diagnostic biomarker. The regulatory effect of miR-129-5p on NAFLD may function by regulating lipid accumulation and insulin sensitivity.

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Clinical relevance of reporting fatty liver on ultrasound in asymptomatic patients during routine health checkups

Cited by 29 publications

References 18 publications

Comparison of liver enzymes and sonological grading in nonalcoholic fatty liver

Comparison of liver enzymes and sonological grading in nonalcoholic fatty liver

The Prevalence of Metabolic Associated Fatty Liver Disease in The Turkish Population: A Multicenter Study

WITHDRAWN: Dysregulation of miR-129-5p in Patients with Non-Alcoholic Fatty Liver Disease and Its Regulatory Effect on Insulin Resistance

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