Clinical Results of Selective Laser Trabeculoplasty in Open-angle Glaucoma in Japanese Eyes

Shibata, Maho; Sugiyama, Tetsuya; Ishida, Osamu; Ueki, Mari; Kojima, Shota; Okuda, Takaaki; Ikeda, Tsunehiko

doi:10.1097/ijg.0b013e3181fc8020

Cited by 68 publications

(54 citation statements)

References 19 publications

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“…Most reported adverse effects for SLT such as discomfort, pain or photophobia are mild and resolve within few days without treatment [34, 35]. The transient IOP rise of ≥5 mmHg occurs in 0 to 28% of eyes studied, [13, 36, 37] and ≥10 mmHg in up to 5.5% of eyes [13, 23]. It usually resolves quickly with or without topical antiglaucomatous treatment, usually within 24 h. Other side effects reported in the literature are: peripheral anterior synechiae, hyphema, bilateral anterior uveitis and choroidal effusion [36, 38, 39].…”

Section: Discussionmentioning

confidence: 99%

Selective laser trabeculoplasty for early glaucoma: analysis of success predictors and adjusted laser outcomes based on the untreated fellow eye

et al. 2016

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BackgroundTo identify success predictors and to study the role of the fellow untreated eye as a co-variable for adjustment of intraocular pressure (IOP) outcomes following selective laser trabeculoplasty (SLT) in early open-angle glaucoma (OAG) patients.MethodsA case series was carried out. Patients with uncontrolled early OAG or ocular hypertension (inadequate IOP control requiring additional treatment) underwent SLT (one single laser session) performed by the same surgeon in a standardized fashion. The same preoperative medical regimen was maintained during follow-up for all patients. Post-treatment assessments were scheduled at week 1 and months 1, 2, and 3. In order to account for possible influence of IOP fluctuation on laser outcomes, post-laser IOP values of the treated eye of each patient were also analyzed adjusting for IOP changes (between visits variation) of the untreated fellow eye (adjusted analysis). Pre and post-laser IOP values were compared using paired t-test. Factors associated with the magnitude of IOP reduction were investigated using multiple regression analysis.ResultsA total of 45 eyes of 45 patients were enrolled. Mean IOP was reduced from 20.8 ± 5.1 to 14.9 ± 2.9 mmHg at month 3 (p < 0.001). Adjusted success rate (defined as IOP reduction ≥ 20%) was 64% and mean percentage of IOP reduction was 23.1 ± 14.3% at last follow-up visit. Considering unadjusted post-laser IOP values, it was found a 20% greater absolute IOP reduction (median [interquartile range] 6 mmHg [4–7] vs 5 mmHg [3–7]; p = 0.04), with a success rate of 76%. Although baseline IOP was significantly associated with both adjusted and unadjusted post-laser IOP reduction, a stronger association was found when unadjusted IOP values were considered (p < 0.001 and R 2 = 0.35; p < 0.001 and R 2 = 0.67, respectively). Age, mean deviation (MD) index, central corneal thickness and type of glaucoma were not significant predictors (p ≥ 0.150).ConclusionsIn this group of patients with early OAG or ocular hypertension, our short-term results confirmed SLT as a safe and effective alternative for IOP reduction. Although better outcomes were found in eyes with higher preoperative IOP, this effect was mitigated when results were adjusted to the fellow untreated eye (to the influence of between visits-IOP fluctuations).

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Section: Discussionmentioning

confidence: 99%

Selective laser trabeculoplasty for early glaucoma: analysis of success predictors and adjusted laser outcomes based on the untreated fellow eye

et al. 2016

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“…26 Baseline IOP also seems to affect the overall reduction in IOP and may serve as a predictor for response to 360-degree SLT. In a study by Shibata et al, 27 pretreatment IOPZ21 mm Hg resulted in a more dramatic decrease in IOP compared with a baseline IOP<21 mm Hg (33.5% ± 17.4% vs. 22.4% ± 17.9%; P<0.05, respectively) in Japanese patients treated with 360-degree SLT. Intermediate amounts of treatment have also been evaluated, and Pehkonen and Valimaki 28 reported that the effect of 270-degree SLT falls within the same range as 180-degree SLT, resulting in a 4.7 ± 3.1 mm Hg (20%) reduction from baseline 6 months after treatment.…”

Section: Laser Trabeculoplastymentioning

confidence: 86%

Surgical Management of Pseudoexfoliation Glaucoma

Kornmann¹,

Gedde²

2014

International Ophthalmology Clinics

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“…Le traitement de 360 • de l'angle iridocornéen donne les meilleurs résultats [10,11]. Par ailleurs, le taux de succès dépend de la définition de « succès », plus ou moins sévère selon les études.…”

Section: Discussionunclassified

Trabéculoplastie sélective au Laser Selecta (SLT) dans le traitement du glaucome chronique à angle ouvert : analyse rétrospective 12 ans après traitement d’une cohorte de 28 patients

Giocanti-Aurégan

Abitbol

Bensmail

et al. 2014

Journal Français d'Ophtalmologie

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Clinical Results of Selective Laser Trabeculoplasty in Open-angle Glaucoma in Japanese Eyes

Abstract: The 360-degree SLT was shown to be more effective than180-degree SLT for intermediateterm reduction in IOP of Japanese patients with open-angle glaucoma as an adjunctive treatment protocol.

Cited by 68 publications

References 19 publications

Selective laser trabeculoplasty for early glaucoma: analysis of success predictors and adjusted laser outcomes based on the untreated fellow eye

Selective laser trabeculoplasty for early glaucoma: analysis of success predictors and adjusted laser outcomes based on the untreated fellow eye

Surgical Management of Pseudoexfoliation Glaucoma

Trabéculoplastie sélective au Laser Selecta (SLT) dans le traitement du glaucome chronique à angle ouvert : analyse rétrospective 12 ans après traitement d’une cohorte de 28 patients

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