Clinical sequelae among individuals with pauci-symptomatic or asymptomatic Ebola virus infection and unrecognised Ebola virus disease in Liberia: a longitudinal cohort study

Kelly, John D.; Ryn, Collin Van; Badio, Moses; Fayiah, Tamba; Johnson, Kumblytee; Gayedyu-Dennis, Dehkontee; Weiser, Sheri D.; Porco, Travis C.; Martin, Jeffrey M.; Sneller, Michael C.; Rutherford, George W; Reilly, Cavan; Fallah, Mosoka; Moses, J Soka

doi:10.1016/s1473-3099(22)00127-x

Cited by 11 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study showed high prevalence rates of post EVD symptoms (9%-50%). Arthralgia (50%), headache (44%), and myalgia (32%) had the highest prevalence, supporting existing evidence [ 28 , 35 , 40 , 43 , 44 ]. Generally, most of the somatic symptoms were relatively more prevalent (except for numbness of hands and feet, and hearing loss) within the first year.…”

Section: Discussionsupporting

confidence: 74%

Prevalence of somatic symptoms among Ebola Virus Disease (EVD) survivors in Africa: a systematic review and meta-analysis

Mandizadza,

Phebeni,

2024

BMC Public Health

View full text Add to dashboard Cite

Background Many Ebola virus disease (EVD) survivors have reported somatic and neuropsychological symptoms after discharge from the Ebola Treatment Unit (ETU). Since the 2014–2016 Ebola epidemic in West Africa, various studies have investigated and identified these symptoms. Evidence on somatic symptoms is widely available in the literature, however, there is no concise overview of the prevalence across different time intervals. Methods This meta-analysis was conducted following the (PRISMA) guidelines. A database search was conducted to identify original studies that reported the prevalence of symptoms. The primary outcome measure was the prevalence rate of several somatic symptoms. Results were pooled, and prevalence rates were assessed over time, to elucidate any particular trends. Results We included 23 studies (5,714 participants). The pooled prevalence was: arthralgia 50% (95% CI: 41%-59%); headache 44% (95% CI: 36%-52%); myalgia 32% (95% CI: 26%-38%); abdominal pain 27% (95% CI: 15%-39%); fatigue 25% (95% CI: 19%-31%); numbness of feet 16% (95% CI: 14%-18%); numbness of hands 12% (95% CI: 10%-14%) and hearing loss 9% (95% CI: 5%-12%). Prevalence across different time intervals revealed significant patterns. All the symptoms persisted for more than 2 years after discharge except for abdominal pain. Conclusion The pooled prevalence rates of somatic symptoms are notably high. Arthralgia and headache are the most prevalent of the symptoms, with hearing loss and numbness in hands and feet being the least. We found that arthralgia, myalgia, and abdominal pain decreased over time. However, headache, fatigue, numbness of hands and feet, and hearing loss increased over time.

show abstract

Section: Discussionsupporting

confidence: 74%

Prevalence of somatic symptoms among Ebola Virus Disease (EVD) survivors in Africa: a systematic review and meta-analysis

Mandizadza,

Phebeni,

2024

BMC Public Health

View full text Add to dashboard Cite

show abstract

“…Ebola virus disease (EVD) is characterized in humans by hemorrhagic fever with high mortality rates ( Feldmann et al, 2013 ; Feldmann and Geisbert, 2011 ). EVD is caused by Ebola virus (EBOV), a member of the Filoviridae family, which in addition to causing acute disease, can also persist in the body of survivors at immunologically protected sites, such as the brain, eyes, or testes ( Glynn et al, 2017 ; Jacobs et al, 2016 ; Kelly et al, 2022 ; Sow et al, 2016 ; Varkey et al, 2015 ). Sexual transmission of filoviruses is now well recognized while it was first suspected with Marburg virus more than fifty years ago ( Martini and Schmidt, 1968 ; Slenczka and Klenk, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals

Escaffre¹,

Popov²,

Hager³

et al. 2023

Antiviral Research

View full text Add to dashboard Cite

“…The emergence of post-Ebola virus syndrome (PES) among survivors further highlights the complex aftermath of Ebola virus infection. This syndrome has been observed in a small subset of individuals who have successfully recovered from the virus (109,110). Despite overcoming the acute phase of the disease, some survivors may experience long-term health effects that encompass a range of symptoms and conditions.…”

Section: Post-ebola Virus Syndromementioning

confidence: 99%

“…PES manifests with a range of clinical symptoms, encompassing conditions like arthralgia, uveitis, arthritis, and psychological stress (109). The health implications faced by EVD survivors have undergone comprehensive evaluation, shedding light on various aspects of the syndrome.…”

Section: Post-ebola Virus Syndromementioning

confidence: 99%

Beyond survival: unraveling the dynamics of Ebola virus resurgence in Sub-Saharan Africa and the remarkable journey of survivors

Asare Fenteng,

Ossei,

Ayibor

et al. 2023

Front. Virol.

View full text Add to dashboard Cite

Ebola virus disease (EVD) remains a significant public health threat, with sporadic outbreaks occurring in Sub-Saharan Africa. Survivors of EVD may experience various post-infection symptoms, collectively known as post-Ebola virus syndrome (PES), which include chronic arthralgia, uveitis, headache, and psychosocial stressors. In this review, we discuss the persistence of Ebola virus in survivors and its possible role in the reemergence of current outbreaks. We highlight that waning immunity of survivors enhances viral persistence and may lead to viral reactivation and recurrence of disease in previously affected tissues. The delicate equilibrium between diminished immune cell surveillance and limited viral replication may lead to enduring chronic inflammation. Our systematic review, based on an extensive survivor cohort, underscores the importance of continued research and preparedness efforts to combat future outbreaks through adequate surveillance and timely public health interventions. This review serves as a comprehensive guide to understanding the complexities of EVD survivorship, the challenges of PES, and the strategies to mitigate its impact.

show abstract

Clinical sequelae among individuals with pauci-symptomatic or asymptomatic Ebola virus infection and unrecognised Ebola virus disease in Liberia: a longitudinal cohort study

Cited by 11 publications

References 25 publications

Prevalence of somatic symptoms among Ebola Virus Disease (EVD) survivors in Africa: a systematic review and meta-analysis

Prevalence of somatic symptoms among Ebola Virus Disease (EVD) survivors in Africa: a systematic review and meta-analysis

Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals

Beyond survival: unraveling the dynamics of Ebola virus resurgence in Sub-Saharan Africa and the remarkable journey of survivors

Contact Info

Product

Resources

About