Clinical significance of co-expression of CD21 and LFA-1 in B-cell lymphoma

Tanimoto, Kazushi; Yakushijin, Yoshihiro; Fujiwara, Hiroshi; Otsuka, Masaki; Ohshima, Koichi; Sugita, Atsuro; Sakai, Akira; Hato, Takaaki; Hasegawa, Hitoshi; Yasukawa, Masaki

doi:10.1007/s12185-009-0303-8

Cited by 4 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD21 encodes a membrane protein that functions as a receptor for Epstein–Barr virus (EBV) binding on B and T lymphocytes. A previous study [25] reported that the prognosis of CD21-positive DLBCL was significantly favorable to that of CD21-negative DLBCL and then a later in vivo experiment [26] showed that CD21 was closely related to LFA-1 expression in B-cell lymphoma (BCL), and the absence of CD21/LFA-1 expression was associated with pleural/peritoneal fluid involvement caused by BCL, which is a potential indicator of BCL progression. It is interesting to note that interleukin-2 receptor beta ( IL2RB ) was significant in the Cox proportional-hazards model.…”

Section: Resultsmentioning

confidence: 99%

Pathway-Based Analysis of the Hidden Genetic Heterogeneities in Cancers

Zhao

Zhong²,

Zuo

et al. 2014

Genomics, Proteomics &Amp; Bioinformatics

View full text Add to dashboard Cite

Many cancers apparently showing similar phenotypes are actually distinct at the molecular level, leading to very different responses to the same treatment. It has been recently demonstrated that pathway-based approaches are robust and reliable for genetic analysis of cancers. Nevertheless, it remains unclear whether such function-based approaches are useful in deciphering molecular heterogeneities in cancers. Therefore, we aimed to test this possibility in the present study. First, we used a NCI60 dataset to validate the ability of pathways to correctly partition samples. Next, we applied the proposed method to identify the hidden subtypes in diffuse large B-cell lymphoma (DLBCL). Finally, the clinical significance of the identified subtypes was verified using survival analysis. For the NCI60 dataset, we achieved highly accurate partitions that best fit the clinical cancer phenotypes. Subsequently, for a DLBCL dataset, we identified three hidden subtypes that showed very different 10-year overall survival rates (90%, 46% and 20%) and were highly significantly (P = 0.008) correlated with the clinical survival rate. This study demonstrated that the pathway-based approach is promising for unveiling genetic heterogeneities in complex human diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

Pathway-Based Analysis of the Hidden Genetic Heterogeneities in Cancers

Zhao

Zhong²,

Zuo

et al. 2014

Genomics, Proteomics &Amp; Bioinformatics

View full text Add to dashboard Cite

show abstract

“…Immunohistochemical analyses of clinical B-cell lymphoma samples revealed CD21 expression in all evaluated cases [ 21 ]. In our study, CD21 expression was found in cells with non-dendritic morphology in the intratumoral and peritumoral areas and in the lymphocytes of the germinal center.…”

Section: Discussionmentioning

confidence: 99%

The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous Cell Carcinomas of the Larynx

Boia,

Ceausu

et al. 2023

Medicina

View full text Add to dashboard Cite

Background and Objectives: Even if they are cells of controversial origin (mesenchymal, perivascular, or fibroblastic), follicular dendritic cells (FDC) are present in all organs. The aim of this study was to establish the FDC expression pattern and its interrelation with HPV 18 expression in laryngeal squamous cell carcinoma (LSCC). Materials and Methods: Fifty-six cases of LSCC were evaluated by simple and double immunostaining. The following score was used: 0 (negative or few positive cells), 1 (10–30% of positive cells), 2 (30–50% of cells), and 3 (over 50% of cells). Results: The expression of CD 21-positive cells with dendritic morphology (CDM) was noticed in the intratumoral area of conventional (well and poorly differentiated types and HPV 18 positive cases with a value of 2 for the score) and papillary types (HPV-18 negative cases with a score of 1). The highest value of 2 for the score of CDM in HPV-18 positive cases was found in the peritumoral area of well- and poorly-differentiated conventional LSCCs. A significant correlation was found between scores of CDM from the intratumoral area and those of the peritumoral area (p = 0.001), between CDM and non-dendritic morphology cells (NDM) of the intratumoral area (p = 0.001), and between HPV-18 status and peritumoral NDM cells (p = 0.044). Conclusions: The FDC and NDM cell score values of intratumoral and peritumoral areas may represent important parameters of LSCCs. This may contribute to a better stratification of laryngeal carcinoma cases and the individualized selection of clinical treatment protocols.

show abstract

“…The LFA-1 absence prevents the leukocyte emigration to inflammation sites, resulting in a severe immunodeficiency (Drillenburg & Pals 2000;Pals et al 2007;Page et al 2012). On the other hand, previous studies have proved that LFA-1 expression provokes cell aggregation limiting its proliferation and its expression is induced by CD21 (complement receptor type 2, CR2, C3d receptor, and mature B-cell marker) (Otsuka et al 2004a;Otsuka et al 2004b;Tanimoto et al 2009;Zhao et al 2014), whose expression is lost in A20 tumour cells. This suggests that A20 B-cell lymphoma line has jointly selected the loss of CD18 and CD21 expression as tumour proliferative and development advantages, reducing the possible cell interaction and aggregation.…”

Section: Molecular and In Vitro Consequences Of The Loss Of Hvem In Amentioning

confidence: 98%

The Role of Hvem and its Interaction with Btla and Cd160 in b-Cell Lymphoma Progression

Juan

2019

Preprint

View full text Add to dashboard Cite

Despite the fact that the cell surface receptor HVEM (TNFRSF14) appears to be implicated in the development and progression of B-cell lymphomas, its specific role in these tumours is still unclear. On the one hand, HVEM overexpression is related to worse prognosis in some types of B-cell lymphoma and other solid tumours. On the other hand, most mutations of HVEM in B-cell lymphomas are thought to promote tumour growth through the loss of function. Here, we used a CRISPR-Cas9 system to study the effect of HVEM loss on gene expression in a murine model of A20 B-cell lymphoma (belonging to the diffuse large Bcell lymphoma group). We show that loss of HVEM does not affect the doubling rate of A20 tumour cells in culture, but leads to a decrease in BTLA expression. HVEM-deficient A20 cells do not present a different pattern of metastatic dissemination to lymphoid organs compared with unmodified A20 cells. However, we observed a significant expansion of endogenous B-cells as a result of A20 tumour implantation in the thymus. Although we found no differences in the dissemination or progression of HVEM-deficient A20 cells, our results reveal that loss of HVEM alters the leukocyte recruitment capacity of A20 cells in hepatic tumour nodules at the intermediate stage of tumour development, which may be of relevance as a mechanism of immune evasion.

show abstract

Clinical significance of co-expression of CD21 and LFA-1 in B-cell lymphoma

Cited by 4 publications

References 45 publications

Pathway-Based Analysis of the Hidden Genetic Heterogeneities in Cancers

Pathway-Based Analysis of the Hidden Genetic Heterogeneities in Cancers

The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous Cell Carcinomas of the Larynx

The Role of Hvem and its Interaction with Btla and Cd160 in b-Cell Lymphoma Progression

Contact Info

Product

Resources

About