Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway

Meng, Fanjun; Zhang, Yuxia; Li, Xing; Wang, Juan; Wang, Zhiyu

doi:10.3892/or.2017.5838

Cited by 32 publications

(14 citation statements)

References 30 publications

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“…Jiang and Liu reported that miR-25 target the RNA-binding motif protein 47 (RBM47) and activated the PI3K/Akt/mTOR signaling pathway in melanoma cells [116]. Meng et al recently demonstrated clinically that miR-138 is significantly upregulated in malignant melanoma patients by regulating the PI3K/Akt/mTOR autophagy pathway via PDK1 dependent expression [117]. Moreover, a study by Li et al also reported that by targeting PIK3R3/AKT3, miR-224-5p suppressed proliferation, migration, and invasion in uveal melanoma (UM) cells, representing a therapeutic and diagnosis target for patients with UM [115].…”

Section: Cutaneous Cancers Associated With Dysregulation Of the Pimentioning

confidence: 99%

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Chamcheu

Roy

Uddin

et al. 2019

Cells

143

122

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The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation, migration, and survival, as well as angiogenesis and metabolism. Dysregulation of these pathways is frequently associated with genetic/epigenetic alterations and predicts poor treatment outcomes in a variety of human cancers including cutaneous malignancies like melanoma and non-melanoma skin cancers. Recently, the enhanced understanding of the molecular and genetic basis of skin dysfunction in patients with skin cancers has provided a strong basis for the development of novel therapeutic strategies for these obdurate groups of skin cancers. This review summarizes recent advances in the roles of PI3K/Akt/mTOR and their targets in the development and progression of a broad spectrum of cutaneous cancers and discusses the current progress in preclinical and clinical studies for the development of PI3K/Akt/mTOR targeted therapies with nutraceuticals and synthetic small molecule inhibitors.

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Section: Cutaneous Cancers Associated With Dysregulation Of the Pimentioning

confidence: 99%

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Chamcheu

Roy

Uddin

et al. 2019

Cells

143

122

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“…Our study revealed several miRNAs that were associated with ESRP1, including miRNA-138. Researchers have found that miR-138, miR-155, and miR-221/222 can be used as the diagnostic and prognostic markers of CMM [ 36 – 38 ]. Some studies have reported that miR-138 has tumor-suppressive effects in malignant diseases of the lung, kidney, tongue, head, and neck [ 39 – 41 ].…”

Section: Discussionmentioning

confidence: 99%

Mining Database for the Clinical Significance and Prognostic Value of ESRP1 in Cutaneous Malignant Melanoma

Wang

Kou

et al. 2020

BioMed Research International

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Background. Epithelial splicing regulatory protein 1 (ESRP1) has been described as an RNA-binding protein involved in cancer development. However, the expression and regulatory network of ESRP1 in cutaneous malignant melanoma (CMM) remain unclear. Methods. From the sequencing data of 103 CMM samples in The Cancer Genome Atlas database, the expression level of ESRP1 and its correlation with the clinicopathological characteristics were analyzed using the Oncomine 4.5, Gene Expression Profiling Interactive Analysis (GEPIA), and UALCAN tools, while LinkedOmics was used to identify differential gene expression with ESRP1 and to analyze Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Gene enrichment analysis examined target networks of kinases, miRNAs, and transcription factors. Finally, TIMER was used to analyze the relationship between ESRP1 and tumor immune cell infiltration. Results. We found that ESRP1 was lowly expressed in CMM tissues, and a low level of ESRP1 expression correlated with better overall survival. Expression of this gene was linked to functional networks involving the condensed chromosomes, epidermal development, and translation initiation. Functional network analysis suggested that ESRP1 regulated ribosome metabolism, drug metabolism, and chemical carcinogenesis via pathways involving several cancer-related kinases, miRNAs, and transcription factors. Furthermore, our results suggested that ESRP1 played an important role in regulating tumor-associated macrophage polarization, dendritic cell infiltration, Treg cells, and T cell exhaustion. Conclusion. Our study demonstrates ESRP1 expression, prognostic value, and potential regulatory networks in CMM, thereby shedding light on the clinical significance of ESRP1, and provides a novel biomarker for determining prognosis and immune infiltration in CMM.

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“…To date, there are a number of studies about micro-RNAs and CM [25][26][27][28] but fewer about lncRNAs and CM. LncRNAs ANRIL [29], BANCR [30], GAS5 [31,32], MALAT1 [33], PVT1 [34,35], SAMMON [36,37], SPRIGHTLY [38,39], SPRY4-1T1 [40,41], and other lncRNAs have been studied for the regulation of melanocyte proliferation, migration, invasion, and other cell biological functions associated with the development and metastasis of CM.…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis of competing endogenous RNA network focusing on long noncoding RNA associated with progression of cutaneous melanoma

Sui

Yang

et al. 2018

Cancer Medicine

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Cutaneous melanoma (CM) is the most malignant tumor of skin cancers because of its rapid development and high mortality rate. Long noncoding RNAs (lncRNAs), which play essential roles in the tumorigenesis and metastasis of CM and interplay with microRNAs (miRNAs) and mRNAs, are hopefully considered to be efficient biomarkers to detect deterioration during the progression of CM to improve the prognosis. Bioinformatics analysis was fully applied to predict the vital lncRNAs and the associated miRNAs and mRNAs, which eventually constructed the competing endogenous RNA (ceRNA) network to explain the RNA expression patterns in the progression of CM. Further statistical analysis emphasized the importance of these key genes, which were statistically significantly related to one or few clinical features from the ceRNA network. The results showed the lncRNAs MGC12926 and LINC00937 were verified to be strongly connected with the prognosis of CM patients.

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Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway

Cited by 32 publications

References 30 publications

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Mining Database for the Clinical Significance and Prognostic Value of ESRP1 in Cutaneous Malignant Melanoma

Integrative analysis of competing endogenous RNA network focusing on long noncoding RNA associated with progression of cutaneous melanoma

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