Clinical study investigating abrasive effects of three toothpastes and water in an in situ model

Macdonald, Emma L; North, Alice; Maggio, Brenda; Sufi, Farzana; Mason, Stephen; Cp, Moore; Addy, M.; West, Nicola

doi:10.1016/j.jdent.2010.03.007

Cited by 48 publications

(48 citation statements)

References 23 publications

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“…In the present study, the between-treatment trends in dentine loss reflected the increasing RDA values of the study treatments. These findings are supportive of an earlier in situ study that also reported significantly greater dentine loss following brushing with moderate or higher abrasivity dentifrices compared with a low abrasivity dentifrice or water [22]. The present study showed that initial rate of dentine loss was faster than the subsequent rate of dentine loss, which was particularly pronounced for the lower RDA pastes.…”

Section: Discussionsupporting

confidence: 91%

“…This study employed an established in situ methodology [22] to explore the effect of brushing with dentifrices of differing abrasivity (RDA) on dentine surface loss. In the present study, the between-treatment trends in dentine loss reflected the increasing RDA values of the study treatments.…”

Section: Discussionmentioning

confidence: 99%

“…The in situ methodology employed in this study is sensitive enough to differentiate the effect on dentine wear of brushing with dentifrices of varying RDA values [20,22,32,36]. Assuming a brushing time of 1 minute twice daily, with approximately 1 second of contact with each tooth surface, the treatment methodology of the present study represents wear in the order of 1 year's brushing (each dentine specimen was brushed for 15 seconds, three times a day for 15 days).…”

Section: Discussionmentioning

confidence: 99%

“…The study was The in situ method used in the current study was based on a previously published in situ abrasion methodology [19,22]. The model employs removable acrylic mandibular appliances that hold the dentine specimens buccally in the oral cavity.…”

Section: Methodsmentioning

confidence: 99%

“…An in situ clinical study demonstrated significantly less dentine loss following use of an ultra-low abrasivity dentifrice (RDA ~15) compared with brushing with moderate (RDA ~70) or higher (RDA ~240) abrasivity formulations, and no significant difference from brushing with water alone [22], i.e. it showed increased dentine loss (equating to wear) with increasing dentifrice abrasivity.…”

Section: Introductionmentioning

confidence: 99%

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A randomised clinical in situ study to evaluate the effects of novel low abrasivity anti-sensitivity dentifrices on dentine wear

Seong¹,

Hall²,

Young³

et al. 2017

Journal of Dentistry

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms 1 A randomised clinical in situ study to evaluate the effects of novel low abrasivity anti-sensitivity dentifrices on dentine wear Key words: Dentine, abrasivity, dentifrice, profilometry, sodium tripolyphosphate, alumina Conflict of interest Author contributionsAll the authors contributed to the design, conduct and reporting of the study. All authors had access to the final study report, made contributions to the development of the manuscript, had final responsibility for the decision to submit, and approved the submitted version. AcknowledgementsThe authors would like to thank Liam Kennedy of GSK Consumer Healthcare for providing the statistical analyses. Editorial assistance was provided by Dr Duncan Porter of Anthemis Consulting Ltd and Dr Eleanor Roberts of Beeline Science Communications Ltd, both funded by GSK Consumer Healthcare. 2A randomised clinical in situ study to evaluate the effects of novel low abrasivity anti-sensitivity dentifrices on dentine wear ABSTRACT Objectives: To compare the abrasive wear on human dentine in an in situ model associated with use of an experimental low abrasivity anti-sensitivity dentifrice containing 1% alumina and 5% sodium tripolyphosphate (STP) with an experimental ultra-low abrasivity nonalumina 5% STP dentifrice, a higher abrasivity daily-use whitening dentifrice, and water as controls.Methods: This was a single-centre, single-blind, randomised, split-mouth, four-treatment, two-period, crossover in situ study in 29 healthy subjects. Subjects wore bilateral lower buccal appliances, each fitted with four dentine specimens. Study treatments were applied ex vivo (three times daily). Dentine loss was measured by non-contact profilometry after 5, 10 and 15 days' treatment.Results: All 29 subjects were included in the efficacy analysis. Significantly less dentine loss was associated with brushing with the low and ultra-low abrasivity dentifrices than with the higher abrasivity dentifrice at all timepoints (p<0.01). Brushing with ultra-low abrasivity dentifrice or water resulted in statistically significantly less dentine loss compared with brushing with the low abrasivity dentifrice at all timepoints (p<0.05). Dentine loss after brushing with ultra-low abrasivity dentifrice was not significantly different from brushing with water. Conclusions:The degree of dentine loss observed in this in situ model reflected the abrasivity of the study dentifrices. Brushing with low or ultra-low abrasivity STP-containing anti-sensitivity dentifrices resulted in significantly less dentine loss (equating to dentine wear) than with a higher abrasivity daily-use whitening dentifrice. Clinical significanceClinicians aim to prevent or manage tooth wear and subsequent conditions, such as dentine hypersensitivity, while helping patients to maintain good stain control. Lo...

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%