Clinical Study of the Efficiency of Combined Cell Transplant on the Basis of Multipotent Mesenchymal Stromal Adipose Tissue Cells in Patients with Pronounced Deficit of the Maxillary and Mandibulary Bone Tissue

Abstract

The use of synthetic osteoplastic materials not always provides the required amount of the bone tissue. Transplantation of tissue-engineering constructs containing osteogenic precursor cells can be an alternative high-technology implantation method. Here we present the results of a pilot clinical study demonstrating safety of this method, accelerated healing of the operation wound, formation of young bone tissue after transplantation, and the possibility of mounting implants after 3 months in case of sufficient amount of the bone for primary fixation.

Adipose mesenchymal stem cells in the field of bone tissue engineering

“…Defects of the skull and jaws have been successfully reconstructed or their healing has been accelerated by the use of hASCs [98][99][100][101][102] , extending our limited knowledge regarding the potential use of hASCs for osseous tissue repair and regeneration. Work published in 2012 by Sándor demonstrates the synergistic effect of hASCs, resorbable scaffolds (β-TCP and bioactive glass) and growth factors (BMP-2), in the treatment of 23 patients with craniofacial osseous defects [103] .…”

Human Adipose-Derived Stromal Cells Stimulate Autogenous Skeletal Repair via Paracrine Hedgehog Signaling with Calvarial Osteoblasts

“…In case reports, defects of the cranium [5], maxilla [6], and mandible [7] have been either healed or enabled to heal faster with the use of hASCs [8]. Such reconstructions eliminate the need for alloplastic materials, and thus reduce the risk of infection, breakdown, or rejection.…”

Ingénierie tissulaire osseuse en chirurgie buccale et maxillo-faciale : applications cliniques

“…Dans 7 études [32,[34][35][36][37][38][39], les ostéoblastes étaient issus d'un prélèvement de périoste, ce qui va dans le sens de procédures moins invasives (prélèvement buccal des cellules souches et amplification in vitro). Dans plusieurs cas, les cellules souches mésenchymateuses (d'origine médullaire, périostée ou pulpaire) induites vers un phénotype ostéoblas-tique ont permis d'obtenir une régénération osseuse significative (sinus lift [33], alvéoles d'extraction [40], augmentation transversale de la crête alvéolaire [37,41], régénération péri-implantaire [42] ou poches parodontales [39]). Les caracté-ristiques communes de ces défauts osseux sont d'une part leur volume limité et d'autre part l'absence de contraintes mécaniques appliquées pendant la cicatrisation.…”