Clinical study on acupuncture for primary insomnia

Shao, Yue

doi:10.1007/s11726-017-1037-4

Cited by 8 publications

(10 citation statements)

References 5 publications

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“…39 In clinical practice, EA at GV20 has been used to treat insomnia and can increase sleep quality, latency, and duration. 40 Therefore, our study was designed to examine whether EA can improve learning and memory impairments caused by SD. In our study, we utilized modified multiple platform methods to establish a rat model of SD and observed the effects of EA at GV20 and ST36 on memory deficit in the SD model rats.…”

Section: Discussionmentioning

confidence: 99%

Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation

et al. 2020

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Background: Sleep is crucial for proper functioning of the brain, whereas lack of sleep is very common in modern society and can cause memory impairment. Hence, it is of great significance to find effective methods to intervene in the pathogenesis of memory impairment. Objective: We designed this study to explore the mechanism underlying the therapeutic effects of electroacupuncture (EA) on the deficits caused by sleep deprivation (SD). Methods: In this study, we first utilized the modified multiple platform method (MMPM) to establish a rat model of SD, which was followed by use of the Y-maze and Morris water maze (MWM) to assess the performance of rats following EA treatment. Results: We found that EA at GV20 and ST36 significantly decreased the number of error reactions, increased the number of active avoidance responses in the Y-maze and shortened the latency of finding the platform in the MWM test in SD + EA versus untreated SD groups. Moreover, EA treatment partially restored SD-induced reductions in hippocampal dopamine (DA) content and significantly increased the levels of phosphorylated (p) synapsin I, calcium/calmodulin-dependent protein kinase (CaMK) II, and tyrosine hydroxylase, which are related to the synthesis and release of DA. Conclusions: In summary, we it appears that EA at GV20 and ST36 may improve SD-induced memory deficits by restoring the quantity of DA in the hippocampus, which is related to activation of CaMK II, synapsin I, and tyrosine hydroxylase. EA may have potential as an alternative therapy for SD and could improve learning and memory deficits among those suffering from sleep deficiency, although this needs verification by prospective clinical studies.

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Section: Discussionmentioning

confidence: 99%

Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation

et al. 2020

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“…The meta-analysis included a total of 12 RCT studies (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) from 2007 to 2022, covering 1,466 participants in Table 1 (the minimum inclusion number was 60 participants and the maximum was 236). These participants were recruited in hospital outpatient and inpatient units as well as in the community, with an average age of 60 years or older.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One (21) study did not mention the grouping method, which we assessed as "unknown". Two (19,20) studies were grouped according to treatment and therefore assessed as "high risk".…”

Section: Random Sequence Generationmentioning

confidence: 99%

Efficacy of acupuncture for hypertension in the elderly: a systematic review and meta-analysis

Wang,

Li,

Feng

et al. 2023

Front. Cardiovasc. Med.

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BackgroundHypertension has now developed into a major public health problem worldwide. Under the existing antihypertensive drug treatment paradigm, problems such as decreasing drug resistance and increasing drug side effects can occur for elderly patients. Acupuncture, a core technique in the non-pharmacological treatment of Chinese medicine, plays an important role in the treatment of elevated blood pressure.ObjectiveThis study aimed to systematically evaluate the effect of acupuncture alone or in combination with antihypertensive drugs on the efficiency of reducing blood pressure and controlling blood pressure in elderly patients with hypertension.MethodsArticles of randomized controlled trials of acupuncture for hypertension in the elderly published before November 2022 were searched in 7 databases. The methodological quality of the literature was evaluated using the Cochrane Risk of Bias Assessment Tool. The primary outcome was the efficiency rate of blood pressure reduction, and the secondary outcome was the change in blood pressure after treatment.ResultsThis study conducted a systematic review and meta-analysis of 12 randomized controlled trials with a total of 1,466 subjects. Among the primary outcome—efficiency rate, acupuncture-only treatment (RR = 1.11, 95% CI: 1.03–1.20, P < 0.01) and acupuncture combined with antihypertensive drug treatment (RR = 1.18, 95% CI: 1.06–1.31, P < 0.01) were significantly different compared with drugs-only treatment. Among the secondary outcomes, SBP (MD: −4.85, 95% CI: −10.39 to −0.69, P = 0.09) and DBP (MD: −1.45, 95% CI: −5.35 to 2.45, P = 0.47) show no significant difference between acupuncture-only treatment and drug-only treatment. Compared to drugs-only treatment, acupuncture plus drugs has more significant efficiency in lowering SBP (MD: −9.81, 95% CI: −13.56 to −6.06, P < 0.01) and DBP (MD: −7.04, 95% CI: −10.83 to −3.24, P < 0.01).ConclusionFor elderly patients with hypertension, acupuncture-only treatment has the same efficiency and antihypertensive effect compared to drug therapy and acupuncture plus drugs outperforms drugs-only treatment. If the patients receive therapy with less frequency per week and longer duration, there will be a more obvious antihypertensive effect. Due to the methodological defects in the included study and the limited sample size of this paper, more well-designed randomized controlled trials are needed for verification.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022376407, PROSPERO (CRD42022376407).

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“…Considering this, we came up with an interesting questioncould acupuncture be used to treat neurological sequelae caused by electrical trauma? However, only four cases of acupuncture as a treatment for electrical injury-induced neurological sequelae have been reported to date and are all reported in China (Huang, 1957;Zheng, 1986;Shao, 1997;Hao, 2005). Despite electrical current is known to cause damage to the nervous system, the pathogenesis of nerve injury after electrical trauma is unknown.…”

Section: Introductionmentioning

confidence: 99%

Neural Mechanism and Effect of Acupuncture for Central Nervous System Diseases

2024

Frontiers Research Topics

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Clinical study on acupuncture for primary insomnia

Cited by 8 publications

References 5 publications

Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation

Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation

Efficacy of acupuncture for hypertension in the elderly: a systematic review and meta-analysis

Neural Mechanism and Effect of Acupuncture for Central Nervous System Diseases

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