Clinical Study on Child’s Height Growth of Mixtures of Cynanchum wilfordii and Phlomis umbrosa Extract

Abstract

Objectives Previous animal studies have shown that mixtures of Cynanchum wilfordii and Phlomis umbrosa extract (IPLUS-CWPU) increases femur length and insulin like growth factor-1 (IGF-1) secretion. IPLUS-CWPU may thus be a promising ingredient in functional foods aimed at growing child's height. The purpose of the study is to investigate the effect of IPLUS-CWPU on height growth in children with short stature. Methods For this purpose, we recruited 90 children aged 4 to 12 years who had heights ranging from the 5th to 25th percentiles of Korean children's growth curve and randomized to either the IPLUS-CWPU or the placebo group. Results The IPLUS-CWPU group showed a significant increase in the change of the height growth compared to the placebo group after 20 weeks of administration (p=0.02). The height growth velosity also showed a statistically significant difference in the test group compared to the placebo group at 10 weeks (p=0.04). The IGF-1 levels showed a tendency to increase in the IPLUS-CWPU group (p=0.08). Moreover, the IPLUS-CWPU significantly increased IGF-1/IGFBP-3 ratio (p=0.02). However, there were no significant differences in blood biochemical parameters including growth hormone, bone age, thyroid stimulating hormone, and osteocalcin levels. Conclusions In conclusion, the data of this trial indicate that IPLUS-CWPU is effective and safe, generally well-tolerated without severe adverse events, in the treatment of children with short stature over a 20 weeks period.

Prescripciones de IBP a los pacientes de una oficina de farmacia, análisis de su ajuste a las recomendaciones y evidencias científicas publicadas

“…Aunque la mayoría de los estudios encontrados estaban realizados con corticoides orales, en un estudio de cohortes retrospectivo en Indianápolis con 19.443 pacientes con asma o EPOC se estudió el efecto gastrointestinal de los corticoides inhalados 259 . La frecuencia de eventos adversos gastrointestinales en los pacientes que utilizaron corticoides inhalados y salbutamol se comparó con la de los pacientes que utilizaron el salbutamol solo.…”