Safety for humans is one of the most important issues for systems in which humans and machines coexist. Man has developed human-friendly devices using functional materials (electrorheological fluids (ERF), magnetorheological fluids (MRF), and magnetic-field sensitive elastomers (MSE)) and applied them to several types of robots and mechatronics devices for health care, life support, and the evaluation of human functioning. In this chapter, projects related to human-machine coexistent systems and functional materials are presented and classified according to their applications.