Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases Due to Flawed Presumptions

Wu, Jingzhu; Zha, Ping

doi:10.2139/ssrn.3697569

Cited by 3 publications

(15 citation statements)

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“…The reductionist model was wrong in all core presumptions. The discoveries of a large number of health influence factors on health [8][9]13] refuted the reductionist treatment model. The discovery of the stress role on personal health [14][15][16][17][18][19][20][21][22][23][24] implies that diseases cannot be cured by focusing on the body part only.…”

Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

“…The findings of cellular damages and the findings of a large number of harmful drugs/chemicals refute the Independent Action Model [56]. The tightly integrated nature of biological pathways in human metabolic pathways networks implies that intervention by a synthetic drug cannot correct a diseased pathway without disrupting other pathways in the metabolic network [9,57,58]. Based on thousands of post-1980 studies, the binary disease category method [9] introduces too many and too big errors.…”

Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

“…The failure is most clearly reflected in cancer research: Drug performance is very poor based on randomly selected reviews for cancer drugs and treatments [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86]. Drug performance is inflated by all model flaws [9], and their real benefits-torisks ratios are magnitudes lower [1]. Most early disease theories are very poor or largely wrong [51] [92][93][94][95][96][97].…”

Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

“…FDA should find that everything from the reductionist, experiment-based research model, disease classification method, most mathematical models, use of statistical models, the use of the binary scale, major disease theories, mechanism-based drug discovery model, outcome-based research approach, symptom-based diagnostic approach, standardized medical research model, symptom-based causation method, etc. are wrong or very poor as long as they are concerned with personal health and chronic diseases [9]. Health is far more complex than any physical system.…”

Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

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FDA Should Re-evaluate All mRNA Vaccines and Revoke Their Use Authorizations (The Short Version).

Wu¹

2022

IJCV

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Drug industry, controlling medical publishers and large media promote flawed medicine for their revenues by systematically laundering medical knowledge in decades. They maintain and promote flawed research models and suppress disruptive discoveries, thereby precluding reform of medicine. In this study, I will deeply explore how the wrong life model, population-based research model, misused clinical trials, flawed statistical models, the symptom based research methods, binary disease classification, failure to address the massive vital organ capacities, failure to correct biases caused by expected delay in realizing side effects, and failure to address the interference effects of non-controllable factors affect the conclusions of “effectiveness and safety” for mRNA vaccines. I will directly analyze three studies that have been relied upon by FDA in approving mNRA use authorizations: one BNT162b2 effectiveness study published in NEJM, one booster shot study published in NEJM and a Seven Integrated Health Care Organizations study published by CDC. I will expose fatal flaws in the frequency risk concept, effectiveness rate, and hazard reduction ratios, and show why 3% death rate, 95% effectiveness rate and 90% mortality reduction are all meaningless and misleading, and should never have been used as treatment guidance. I will also examine common biases that can be easily practiced by sponsors’ researchers to alter conclusions in favor of approval. By relying on laundered medical “knowledge”, FDA has consistently failed to predict latent drug side effects for any drugs and vaccines in its history. FDA approved disastrous DES in 1941, Swine Flu vaccine in 1976, and mRNA vaccines in 2020. The vaccines are used to deliver short-term benefits on a small percent of persons at the costs of damaging health, causing deaths that could be avoided, and shortening lifespans for all people in the population. I thus urge FDA to reevaluate all mRNA vaccines and revoke their use authorizations.

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Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

Section: Medicine Developed On Flawed Foundationmentioning

confidence: 99%

See 2 more Smart Citations

FDA Should Re-evaluate All mRNA Vaccines and Revoke Their Use Authorizations (The Short Version).

Wu¹

2022

IJCV

Self Cite

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“…A few harmless DES pills could ruin a female user, her daughter and the babes of the daughter. I conducted this analysis because I collected evidence and finally proved that problems lie in medical research models [1][2]. All key presumptions: statistical distribution, separation between mind and body, use of mathematical models, use of binary scale, etc.…”

Section: Introductionmentioning

confidence: 99%

Expression of Concern: Potential Risks and Unknown Effects of mRNA Vaccines On Population Health (5th Rev.)

Wu¹

2021

Preprint

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The litigation outcome of Rundup caused me to examine the risks of the two mRNA vaccines (Pfizer/BioNTech and Moderna), which are used in the population vaccination campaign in the U.S. I will explain the flaws in clinical trials and side-effect evaluation methods, and limitations in laboratory studies and mechanism studies. In addition, I will examine the history of product liabilities and consistent failure of past medical studies to predict severity of drug side effects. Based on all evidence, I conclude that the vaccination may pose many risks that have not been studied and cannot be ruled out. I predict that vaccines will increase cancer risks through its adverse impacts on Central Nervous System and negatively affect the future health of the population in the long run. The vaccines may alter the normal selecting process for viral evolution and will worsen future pandemic measures. It is important for people to understand those issues before they can give their informed consent for being vaccinated.

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Expression of Concern: Potential Risks and Unknown Effects of mRNA Vaccines on Population Health (6th Rev). Damages Are Being Materialized

Wu¹

2022

IJCV

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Several mRNA vaccines are used on the population in the U.S. I started predicting the dangers of mRNA vaccines before March 2021 and update my findings periodically. My prior model study enabled me to identify many flaws in clinical trials, side-effect evaluation methods and mechanism studies, and I also considered consistent failure in predicting drug side effects in the past and systematic failure of FDA in keeping out dangerous drugs from market. I found that the risks of vaccination cannot be determined by experiments alone and must be determined by using a combination of methods. By studying mRNA expression dynamics and kinetics, I predict that vaccination with mRNA vaccines may increase cancer risks, multiple organ failure risks, earlier death risks, genome alteration speeds by one or more mechanisms, alter the normal selection process for viral evolution resulting in more virulent viruses, and aggravate chronic diseases or cause healed diseases to relapse. Two root problems are practical inability to control expression sites and severe adverse reactions from repeated vaccination. Based on mRNA bio-distribution, the mRNA mainly strikes the liver and other vital organs, and poses grave dangers to persons whose vascular functional reserves are relatively small, or whose vascular systems are temporarily burdened by other causes such as viral infections or life activities. If an mRNA vaccine is administered on a pregnant woman by second or booster shots, spike protein synthesis in fetus brain disrupts the highly regulated protein synthesis processes, resulting in potential brain damages. In less than a year, most of my early predicted damages are being materialized or are on the track to hit the population. In this update, I present a benefits-and-risks map to show how the number of deaths caused by mRNA vaccines is grossly underestimated and why claimed benefits like 95% effectiveness rate and 90% death rate reduction are meaningless and misleading.

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Clinical Trials and Reductionist Approach Preclude Cures for Chronic Diseases Due to Flawed Presumptions

Cited by 3 publications

References 0 publications

FDA Should Re-evaluate All mRNA Vaccines and Revoke Their Use Authorizations (The Short Version).

FDA Should Re-evaluate All mRNA Vaccines and Revoke Their Use Authorizations (The Short Version).

Expression of Concern: Potential Risks and Unknown Effects of mRNA Vaccines On Population Health (5th Rev.)

Expression of Concern: Potential Risks and Unknown Effects of mRNA Vaccines on Population Health (6th Rev). Damages Are Being Materialized

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