Clinical utility and tolerability of JSPH-1 wireless esophageal pH monitoring system

Abstract

BackgroundWireless esophageal pH monitoring system is an important approach for diagnosis of gastroesophageal reflux disease (GERD), the aim of this study is to test the tolerability and utility of the first wireless esophageal pH monitoring system made in China, and evaluate whether it is feasible for clinical application to diagnose GERD.MethodsThirty patients from Department of Gastroenterology of The First Affiliated Hospital of Chongqing Medical University who were suspected GERD underwent JSPH-1 pH capsule. The capsule was placed 5 cm proximal to the squamocolumnar junction (SCJ) by endoscopic determination, the data was recorded consecutively for 48 hours. Then all pH data was downloaded to a computer for analysis. The discomforts reported by patients were recorded.Results30 patients were placed JSPH-1 pH capsule successfully and completed 24-hour data recording, 29 patients completed 48-hour data recording. One patient complained of chest pain and required endoscopic removal. No complications and interference of daily activities were reported during data monitoring or follow-up period. 48-hour pH monitoring detected 15 patients of abnormal acid exposure, on day1 detected 9 patients, the difference had statistical significance (P<0.01). Positive symptom index (SI) was identified in 3 patients with normal pH data in both 24-hours. In total, 48-hour monitoring increased diagnosis of GERD in 9 patients.Conclusion48-hour esophageal pH monitoring with JSPH-1 wireless pH monitoring system is safe, well tolerated and effective. It can be feasible for clinical application to diagnose GERD.

Capsule Design for Blue Light Therapy against Helicobacter pylori

“…The measuring range and resolution of pH sensor are the most significant parameters of the design. The pH values range from 1 to 7.5 for the whole digestive tract with a pH value about 7 in the esophagus, 1~4 for the gastric juice, and 6.6~7.5 for the intestinal juice [ 16 – 18 ]. Clearly, the sensor needs to cover the entire pH range with a resolution less than 2.6 (2.6 is the smallest difference in pH value between different digestive organ).…”

The Current Main Types of Capsule Endoscopy

“…Clinical application research shows that OMOM pH capsule wireless monitoring system is safe and efficient for diagnosing GERD. Long continuous monitoring time can reflect the status of the gastroesophagus reflux, which leads to high GERD positive detection rate, and it can effectively evaluate the frequency and severity of the reflux [55]. Comparing with traditional pH monitoring method such as catheter-based monitoring and endoscopy, it has similar diagnosis effect, but with easier and more convenient clinical operation [56,57]; also, long monitoring time of 96 h is not only effective for GERD diagnosis in the early stage, but also effective for assisting therapeutic decision in the later stage, and it evaluates the effectiveness of medical treatment.…”

Design of pH Measuring in Wireless Therapy Capsule Against Helicobacter Pylori Infections

“…The measuring circuit amplifies the voltage signal from the pH sensor so that the MCU can acquire the analog voltage signal accurately. The pH values range from 1 to 7.5 for the whole digestive tract with a pH value about 7 in the esophagus, 1~4 for the gastric juice, and 6.6~7.5 for the intestinal juice [12]. Clearly, the sensor needs to cover the entire pH range with a resolution less than 2.6.…”