Clinical Utility of the Logarithmically Transformed Ratio of Triglycerides-to- High-Density Lipoprotein Cholesterol and Its Relationship with Other Atherosclerosis-Related Lipid Factors in Type 2 Diabetes

ObjectiveThis study aims to investigate the relationship between serum vitamin D levels and the atherogenic index of plasma (AIP) in individuals aged 20 years and above, as well as analyze potential influencing factors.MethodsA total of 9,637 participants aged 20 years and above from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018 were included in this study. The AIP was calculated using the formula log[triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C)]. Due to the skewed distribution of serum vitamin D levels in the study population, a normal transformation was performed. Weighted multivariate linear regression models were used to assess the linear relationship between the transformed serum vitamin D levels and AIP. Subgroup analysis was conducted by stratifying the data based on age, gender, and race to evaluate the stability of the relationship between serum vitamin D levels and AIP in different populations. In addition, a smooth curve fitting and generalized linear models were employed to examine the nonlinear relationship between serum vitamin D levels and AIP.ResultsAfter controlling for confounding factors, the multivariate linear regression analysis revealed a negative correlation between serum vitamin D levels and AIP [β = −0.0065, 95% CI: (−0.0106, −0.0024)]. This negative correlation was significant in male participants [β = −0.0077, 95% CI: (−0.0142, −0.0011)], Non-Hispanic Black participants [β = −0.0135, 95% CI: (−0.0211, −0.0059)], as well as participants aged 40–50 [β = −0.0124, 95% CI: (−0.0226, −0.0022)] and 60–70 [β = −0.0118, 95% CI: (−0.0214, −0.0023)]. Furthermore, a nonlinear relationship and saturation effect were observed between the transformed serum vitamin D levels and AIP, with a turning point at 8.5617 nmol/L.ConclusionOur study revealed a significant negative correlation and saturation effect between serum vitamin D levels and AIP.

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The Role of the Pro-Inflammatory Cytokine Interferon-Gamma in Type 2 Diabetes and Its Correlation with Atherosclerosis

Al-Tamimi

Al-Shawk

Al-Karawi

2022

Mustansiriya Medical Journal

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Background: Immunity plays a major role in the development of atherosclerosis in type 2 diabetes mellitus (T2DM). Pro-inflammatory cytokines, such as interferon gamma (IFN-γ), play an important role in atherosclerosis-related inflammation. Aims: This study aims to determine whether IFN-γ level and AIP in patients with T2DM are associated with atherosclerosis development and the effect of IFN-γ concentration level in disease progression. Materials and Methods: This study involved 60 Iraqi T2DM patients (30 with dyslipidemia and 30 without dyslipidemia) with an age range of 35–70 years. For the purpose of comparison, 22 healthy participants comparable for T2DM were included in the study. Results: this study shows a significant increase in IFN-γ level in the patient groups as compared to the control group (P < 0.009). There was a gradualincrease of AIP in the three studied groups with a significant difference (P < 0.001). Conclusion: The level of IFN-γ and the AIPmay reflect the progression atherosclerosis which may give an alarming sign in studying group patients.

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Clinical Utility of the Logarithmically Transformed Ratio of Triglycerides-to- High-Density Lipoprotein Cholesterol and Its Relationship with Other Atherosclerosis-Related Lipid Factors in Type 2 Diabetes

Cited by 3 publications

References 29 publications

Association between exposure to arsenic and the risk of cardiovascular disease: Potential role of vascular endothelial injury

Association between exposure to arsenic and the risk of cardiovascular disease: Potential role of vascular endothelial injury

Relationship between serum vitamin D levels and the atherogenic index of plasma: a study based on NHANES database 2011–2018

The Role of the Pro-Inflammatory Cytokine Interferon-Gamma in Type 2 Diabetes and Its Correlation with Atherosclerosis

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