Clinically important potential drug-drug interactions in outpatient settings

Aparasu, Rajender R.; Baer, Rebecca K.; Aparasu, Anuradha

doi:10.1016/j.sapharm.2006.12.002

Cited by 60 publications

(63 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was similar to the study conducted by Patel et al, 2011, Riechelmann et al, 2007, Riechelmann et al, 2008, Dinesh et al, 2007 Of the pDDIs (n=390) observed, majority were of pharmacodynamic (n=202, 51.80%) in nature followed by pharmacokinetic (n=188, 48.20%). These findings were contrast to the study reported by Vonbach et al, 2008 andAparasu et al, 2007. Most frequent DDI was seen between Metformin + Ranitidine (moderate interaction) in 70 prescriptions (50%) and between Ranitidine + Acetaminophen (minor interaction) in 48 prescriptions (34.29%). The common major interactions were seen between Rabeprazole + Clopidogrel in 4 prescriptions (2.86%), Enalapril + Spironolactone and Ciprofloxacin + Tramadol in 3 prescriptions (2.14%).…”

Section: Discussioncontrasting

confidence: 97%

Study of Drug-Drug Interactions in General Medicine Department of a Tertiary Care Hospital

Kousalya¹,

Kumar²,

Punniyakotti³

et al. 2015

J App Pharm Sci

View full text Add to dashboard Cite

Objectives Drug therapy (DT) is growing more complex, thus appropriate drug prescription becomes increasingly challenging. Drug interactions (DI) are one of the important factors that modify the response to a drug. The main objective of this study was to monitor the potentially serious and significant Drug-Drug Interactions (DDIs). Material and methods The number of drugs prescribed for each patient, drugs taken by the patient and the drug interactions were recorded. The interactions between the drugs were assessed using Micromedex software and Stockley's Drug Interaction. The type and severity of prescription with DDIs was also assessed. Results The number of potential DDIs for the study population was 390 and each prescription had at least one interaction. Of the total potential DDIs (n=390) identified, majority were of moderate severity (n = 257, 65.90%). Most frequent DDI was seen between Metformin + Ranitidine (moderate interaction) in 70 prescriptions (50%) and between Ranitidine + Acetaminophen (minor interaction) in 48 prescriptions (34.29%). The common major interactions were seen between Rabeprazole + Clopidogrel in 4 prescriptions (2.86%), Enalapril + Spironolactone and Ciprofloxacin + Tramadol in 3 prescriptions (2.14%). ConclusionThe drug related problems, primarily the drug interactions is a permanent patient related risk in hospitals and the utilization of computer software has become the best way to identify and prevent them.

show abstract

Section: Discussioncontrasting

confidence: 97%

Study of Drug-Drug Interactions in General Medicine Department of a Tertiary Care Hospital

Kousalya¹,

Kumar²,

Punniyakotti³

et al. 2015

J App Pharm Sci

View full text Add to dashboard Cite

show abstract

“…In the study conducted in Brazilian primary public health system the most commonly drug pairs were digoxin and furosemide/hydrohlorothiazide, captopril/losartan and spironolactone, and acidum acetylsalicylicum and ticlopidine [22]. In ambulatory medical care practices in the US, Aparasu et al identified that warfarin included in the three most commonly DDIs pairs [17], similar to the results of study was conducted in Italian outpatients [31].…”

Section: Icd-10-cm Code M00-m99mentioning

confidence: 65%

“…In the previous studies were conducted in primary health care, incidence and prevalence of clinical important potential DDIs varied widely [17,[19][20][21][22]. However, comparison of the results should be done cautiously.…”

Section: Discussionmentioning

confidence: 99%

“…However, comparison of the results should be done cautiously. For example, Aparasu et al used 24-month observed period and studied potential for 25 clinical significant DDIs [17] in the population at large, while Obreli Neto et al studied potential DDIs for 12 drug pairs in the elderly using 6-month observed period [22], in the present study was used 1-month observed period and all clinical significant potential DDIs were identified according to Drug Interaction Facts™ [16] in the population at large.…”

Section: Discussionmentioning

confidence: 99%

“…For that purpose, the prevalence of potential DDIs was examined. Results presented that risk for DDIs varied widely, ranged between 0.63% and 47.4% [17][18][19][20][21][22]. Additionally, the frequency study of potential DDIs at geriatric outpatient in 6 European countries showed that there were differences in frequency, as well as in the type of potential DDIs [23].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and predictors of potential drug-drug interactions

Nikolic¹,

Janković

Stojanov³

et al. 2014

Open Medicine

View full text Add to dashboard Cite

show abstract

Effect of E‐Prescribing Systems on Patient Safety

Kannry

2011

Mount Sinai J Medicine

View full text Add to dashboard Cite

E-prescribing systems enable electronic transmissions of prescriptions to pharmacies from the provider's office. The promise of e-prescribing in regard to patient safety is reduction in the time gap between point of care and point of service, reduction in medication errors, and improved quality of care. This article will give a brief overview of e-prescribing systems, what is known about these systems and their impact on patient safety, and what challenges remain. For purposes of this article, the term "patient safety" will be used interchangeably with medication errors and adverse drug events. Although there is some evidence that e-prescribing alone and e-prescribing with medication decision support can reduce medication errors, there is also evidence that e-prescribing can be a source of medication errors. The need for more study is particularly relevant and timely, as the Centers for Medicare and Medicaid Services is strongly incentivizing providers to use e-prescribing with medication decision support. Despite concerns about efficiency and dissatisfaction, the majority of providers believe e-prescribing provides for improved patient safety. Limited evidence suggests that e-prescribing with medication decision support can improve patient safety.

show abstract

Clinically important potential drug-drug interactions in outpatient settings

Cited by 60 publications

References 19 publications

Study of Drug-Drug Interactions in General Medicine Department of a Tertiary Care Hospital

Study of Drug-Drug Interactions in General Medicine Department of a Tertiary Care Hospital

Prevalence and predictors of potential drug-drug interactions

Effect of E‐Prescribing Systems on Patient Safety

Contact Info

Product

Resources

About