Clinically Improvement in a Case of COVID-19 with Gastrointestinal Manifestations through Using Natural Therapy based on Persian Medicine: A Case Report

Siahpoosh, Marzieh Beygom

doi:10.18502/tim.v5i3.4319

Cited by 1 publication

(1 citation statement)

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“…Medicinal plants have been a reliable source of natural drugs, including antiviral agents, since ancient times. Traditional medicine and ethnopharmacological studies of different countries all over the world have always opened new ways for drug discovery [ 18 , 19 , 20 , 21 , 22 ]. Oseltamivir which is a conventional antiviral agent, is a derivative of shikimic acid, a secondary metabolite of star anise ( Illicium verum Hook.f.).…”

Section: Introductionmentioning

confidence: 99%

Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic Review

et al. 2021

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A newly diagnosed coronavirus in 2019 (COVID-19) has affected all human activities since its discovery. Flavonoids commonly found in the human diet have attracted a lot of attention due to their remarkable biological activities. This paper provides a comprehensive review of the benefits of flavonoids in COVID-19 disease. Previously-reported effects of flavonoids on five RNA viruses with similar clinical manifestations and/or pharmacological treatments, including influenza, human immunodeficiency virus (HIV), severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and Ebola, were considered. Flavonoids act via direct antiviral properties, where they inhibit different stages of the virus infective cycle and indirect effects when they modulate host responses to viral infection and subsequent complications. Flavonoids have shown antiviral activity via inhibition of viral protease, RNA polymerase, and mRNA, virus replication, and infectivity. The compounds were also effective for the regulation of interferons, pro-inflammatory cytokines, and sub-cellular inflammatory pathways such as nuclear factor-κB and Jun N-terminal kinases. Baicalin, quercetin and its derivatives, hesperidin, and catechins are the most studied flavonoids in this regard. In conclusion, dietary flavonoids are promising treatment options against COVID-19 infection; however, future investigations are recommended to assess the antiviral properties of these compounds on this disease.

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