Clinico – histopathological correlation in leprosy: a tertiary care hospital based study

Thapa, Deeptara Pathak; Jha, Anil Kumar

doi:10.7241/ourd.20133.71

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…[18] Dermal infiltrate mainly consisted of infiltrate around Neurovascular (NV) bundles in 33%, followed by infiltrate round Adnexa in 26.66%,infiltrate round Arrector pilorum in 21% and combined infiltrate round Adnexal & nerve in 18%. These features were in contrast to Thappa and Jha [13] who observed epidermal changes in 29.5%, granuloma in 42%, adnexal infiltrate in 7%, nerve infiltrate in 11%, combined adnexal and nerve infiltrate in 6%. Dermal infiltrate in 46.4% cases constituted of lympho-histocytes in their study while it correlating well with our study (46.7%).…”

Section: Discussioncontrasting

confidence: 44%

“…[12] Due to its clinical diversity as well as its ability to mimic other diseases, leprosy is sometimes difficult to diagnose clinically, making histopathological examination a helpful diagnostic tool to confirm the diagnosis. [13] Clinical classification gives recognition only to gross appearances of the lesions, while parameters used in histopathological classification are precise taking into the account the progression and regression of disease under treatment. [14] Great variation in the interpretation of clinical and histopathological observations amongst various researchers in their studies prompted us to undertake this study.…”

Section: Introductionmentioning

confidence: 99%

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A Clinico-Pathological Correlation Study of Leprosy in a Tertiary Care Teaching Institute in Northwest Punjab, India

Badhan¹,

Kundal²,

Raj³

et al. 2014

AJMSM

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Background: Leprosy continues to be a predominant public health problem in India despite rapid strides made for its prevention, detection and treatment since ages. As leprosy can occur in any form due to immunological status of the patient, its clinico-pathological correlation gains more importance. Aim: The present research was undertaken to ascertain the importance of skin biopsy in detecting and diagnosing difficult cases where clinical diagnosis alone is not sufficient and a clinico-pathological correlation study in leprosy assumes greater significance. Method: This was a hospital based prospective study conducted in 60 cases of clinically diagnosed, newly untreated or suspected cases of leprosy for two years among patients attending OPD Department of Dermatology and whose skin biopsies were processed in the department of Pathology with Haematoxylin & Eosin stain along with special stain (Fite Faraco) to ascertain clinico-pathological correlation in leprosy cases. Results: A total of 60 cases were studied. Out of them 71.7% were males and 28.3% females. Majority of them 31.7% belonged to the age group of 21-30 years and children were least affected. Clinico-histopathological classification concordance was noted maximum in LL (80%) followed by BT (77.2%), TT (76.4%), BL (75%), BB (71.4%) and least in IL (60%). Overall concordance between clinical and histopathological diagnosis observed in our study was 75%. Conclusion: Diagnosing and treating leprosy solely on clinical basis still poses a problem while histopathology helps in making a definite diagnosis. This study shows a good correlation among clinical and histopathological findings in skin biopsy.

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Section: Discussioncontrasting

confidence: 44%

Section: Introductionmentioning

confidence: 99%

A Clinico-Pathological Correlation Study of Leprosy in a Tertiary Care Teaching Institute in Northwest Punjab, India

Badhan¹,

Kundal²,

Raj³

et al. 2014

AJMSM

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“…9 Thapa et al found the most common types to be tuberculoid in their study. 10 5 cases belonged to pauci-bacillary category and 45 cases belonged to multi-bacillary category are found in our study. in study done by Roy at al 30 cases (60%) cases in our study were paucibacillary and 20 (40%) cases multibacillary which is agreed with other studies.…”

Section: Discussionsupporting

confidence: 62%

Nerve conduction study: can it diagnose leprosy early?

et al. 2020

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Background: Leprosy is a chronic infectious disease which predominantly involves skin and peripheral nerves. Most important consequences of leprosy are due to the involvement of peripheral nerves which leads to gross deformities and disabilities. Detection of preclinical nerve function impairment can help in the prevention of deformities and disabilities. The objective of the study was role of nerve conduction study (NCS) to detect nerve function impairment (NFI) in leprosy.Methods: An electrophysiological study was conducted for 50 newly diagnosed cases of leprosy from December 2017 to July 2019 at Department of Dermatology, Osmania Medical College, Hyderabad. Nerve conduction velocities, amplitude, and latencies of ulnar, median, common peroneal, posterior tibial, sural nerves are measured.Results: 10 nerves in each patient with a total of 500 nerves were studied by NCS. Only 8 (16%) cases had totally normal NCS. And rest 42 (84%) cases have abnormal NCS. Most common pattern observed is sensory motor axonal neuropathy. A total of 268 (53.6%) nerves were normal before starting multidrug therapy and 232 (46.4%) nerves have abnormal NCS. Among these nerves the involvement of Sensory nerves (49%) are more than motor nerves (42%).Conclusions: NCS is a reliable and reproducible test to detect the early NFI. Though it cannot directly diagnose leprosy, it can be used in suspected cases, newly diagnosed cases, and household contacts to detect the NFI early and prevent the complications associated with it.

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“…The present study also included relapse cases, histoid leprosy and lepra reactions which are similar to other studies. 3,6,9,18 www.pacificejournals.com/apalm eISSN: 2349-6983; pISSN: 2394-6466…”

Section: Discussionmentioning

confidence: 99%

A Study of Clinico-Histopathological Correlation of Leprosy in A Tertiary Care Hospital, KIMS, Hubballi, Karnataka

Sindhushree

Vernekar

2019

APALM

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Clinico – histopathological correlation in leprosy: a tertiary care hospital based study

Cited by 9 publications

References 4 publications

A Clinico-Pathological Correlation Study of Leprosy in a Tertiary Care Teaching Institute in Northwest Punjab, India

A Clinico-Pathological Correlation Study of Leprosy in a Tertiary Care Teaching Institute in Northwest Punjab, India

Nerve conduction study: can it diagnose leprosy early?

A Study of Clinico-Histopathological Correlation of Leprosy in A Tertiary Care Hospital, KIMS, Hubballi, Karnataka

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