Clinico-microbiological study and antimicrobial drug resistance profile of diabetic foot infections in North India

Zubair, Mohammad; Malik, Abida; Ahmad, Jamal

doi:10.1016/j.foot.2010.10.003

Cited by 118 publications

(124 citation statements)

References 31 publications

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“…In strict accordance with other western studies [3,4], but unlike studies from India and other Asian countries [24], we isolated relatively few aerobic gram-negative organisms.…”

Section: Discussionsupporting

confidence: 91%

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Clinical and bacteriological survey of diabetic foot infections in Lisbon

Mendes

Marques-Costa

Vilela³

et al. 2012

Diabetes Research and Clinical Practice

127

101

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Infection Microbiology Portugal a b s t r a c tAims: An epidemiological survey of diabetic foot infections (DFIs) in Lisbon, stratifying the bacterial profile based on patient demographical data, diabetic foot characteristics (PEDIS classification), ulcer duration and antibiotic therapy.Methods: A transversal observational multicenter study, with clinical data collection using a structured questionnaire and microbiological products (aspirates, biopsies or swabs collected using the Levine method) of clinically infected foot ulcers of patients with diabetes mellitus (DM).Results: Forty-nine hospitalized and ambulatory patients were enrolled in this study, and 147 microbial isolates were cultured. Staphylococcus was the main genus identified, and methicillin-resistant Staphylococcus aureus (MRSA) was present in 24.5% of total cases. In the clinical samples collected from patients undergoing antibiotic therapy, 93% of the antibiotic regimens were considered inadequate based on the antibiotic susceptibility test results. The average duration of an ulcer with any isolated multi-drug resistant (MDR) organism was 29 days, and previous treatment with fluoroquinolones was statistically associated with multidrug resistance.Conclusions: Staphylococcus aureus was the most common cause of DFIs in our area. Prevalence and precocity of MDR organisms, namely MRSA, were high and were probably related to previous indiscriminate antibiotic use. Clinicians should avoid fluoroquinolones and more frequently consider the use of empirical anti-MRSA therapy.

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“…In strict accordance with other western studies [3,4], but unlike studies from India and other Asian countries [24], we isolated relatively few aerobic gram-negative organisms.…”

Section: Discussionsupporting

confidence: 91%

“…Most of the other international studies that have reported a similarly high percentage of MDR organisms were single-center, hospital-based studies [24]. The high prevalence in such studies may be explained by the institution's use of broad spectrum antibiotics, resulting in a pathogen-selective survival advantage.…”

Section: Discussionmentioning

confidence: 99%

Clinical and bacteriological survey of diabetic foot infections in Lisbon

Mendes

Marques-Costa

Vilela³

et al. 2012

Diabetes Research and Clinical Practice

127

101

View full text Add to dashboard Cite

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“…16 Observation was comparable with the earlier studies by various authors. Gram negative bacilli dominance in the aerobic growth in pus has been highly recorded by studies reported by Ghosh et al and Zubair et al 17,18 As per our present study we isolated 106 MDR strains from 154 isolates of P. aeruginosa out of 763 pus samples obtained from various patients of the hospital. In accordance with the data the prevalence rate of P. aeruginosa was 20.19% thus data can be correlated to the earlier study conducted like, Sharma et al reported-on Pseudomonas aeruginosa to be 20%, P. aeruginosa was 21.49% in a study of Rao et al, a private hospital in Chennai reported 29.8% strains among diabetic foot ulcer patients were P. aeruginosa.…”

Section: Discussionsupporting

confidence: 70%

Antibiotic profiling of Pseudomonas aeruginosa isolates from pus sample of rural tertiary care hospital of Western Maharashtra, Loni, India

Choudhari

Das

2017

Int J Res Med Sci

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Background: Pseudomonas aeruginosa (P. aeruginosa) considered as an opportunistic pathogen which can be isolated from various kinds of infection. The risk of emergence of antibiotic resistance is based on different antibiotic treatments. Antibiotic resistance and flexibility to adapt changing environment renders the pathogens a matter of concern in hospital acquired infections. Changing pattern of antimicrobial resistance pose challenge in treating pyogenic infections, hence periodical monitoring of bacterial profile and their antibiotic susceptibility pattern is important. This study deals with the infectious and drug resistance nature of P. aeruginosa with effectiveness of antimicrobial agents against it.Methods: Present study was conducted in Centre for Biotechnology, Pravara Institute of Medical Sciences, Loni, Maharashtra, India. A total of 763 pus samples were received in the bacteriology section of department of microbiology, rural medical college, Loni from the various wards of Pravara Rural Hospital. The colonial morphology and identification was done as per standard microbiology procedures. Antibiogram testing was done as per Kirby Bauer disc diffusion method.Results: Out of 763 pus samples 154 were Pseudomonas aeruginosa thus showing 20.19% prevalence. In this study, it was observed that isolates were sensitive to Ciprofloxacin (76.63%) followed by Amikacin. However, showed 90.90 % resistant to Cefazolin followed by Co-trimoxazole 75.97% was observed. Multi drug resistance (MDR) strain 68.83% (N=106) was detected from 154 isolates strains of Pseudomonas aeruginosa. Prevalent resistance pattern was found to be GENr, AKr, CAZr, CZr, COTr for 10 (9.43%) isolates followed by GENr, CAZr, CZr, MRPr, COTr, CIPr for 9 (8.49%) isolates.Conclusions: Present study focused on antibiotic resistance pattern of P. aeruginosa from pus sample. This study contributes in understanding the emergence of MDR strains which can be considered for judicial usage of antibiotics in hospital settings.

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“…were the most common Gram Negative Bacilli (GNB) isolated from the pus samples in our study. Such GNB dominance in the aerobic growth in pus culture has been highly seconded by studies reported by Ghosh A et al [8] and Zubair M. et al [9] . Another study by Basu S. et al [10] also reported Pseudomonas and E. coli spp.…”

Section: Discussionmentioning

confidence: 83%