Clinico-pathological evaluation and etiological stratification of chronic AUB patients based on PALM-COEIN classification: A prospective study in tertiary care center of Nalgonda District

Gubbala, Srinivas Dd; Mattaparti, Sridevi

doi:10.33545/pathol.2019.v2.i1c.26

Cited by 4 publications

(8 citation statements)

References 13 publications

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“…However, obesity, hypertension and diabetes are also implicated as important in the pathogenesis of endometrial cancer. Our results were at the lower end of the range reported in the previous literature where the prevalence of AUB-M ranges from 1.9% to 21.6% ( 12 , 13 , 14 , 16 , 17 , 18 , 19 ).…”

Section: Discussionsupporting

confidence: 48%

“…Our findings of 14% AUB-A prevalence are in accordance with the previous literature on women from India and China. Indeed, a range of 4.9 to 20% of patients with AUB-A out of a total of patients with AUB is described in the previous literature ( 12 , 13 , 14 , 16 , 17 , 18 ).…”

Section: Discussionmentioning

confidence: 97%

“…Six previous studies from India and 1 from China reported a prevalence of AUB-P ranging from 2% to 16.2% ( 12 , 13 , 14 , 16 , 17 , 18 , 19 ).…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

“…Gubbala and Mattaparti ( 17 ) in 2019 in India studying a population up to 75 years old found that AUB-E was the most common AUB subtype, with 41.9% of the cases. Gubbala and Mattaparti ( 17 ) obtained a histopathological sample for each of their patients. On the contrary, in our study the endometrial samples were obtained only at the clinician's discretion and this could be the reason for the different prevalence of AUB-E between our findings and the study of Gubbala and Mattaparti ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

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Abnormal uterine bleeding types according to the PALM-COEIN FIGO classification in a medically underserved American community

Sabre¹,

Serventi²,

Nuritdinova³

et al. 2021

J Turkish German Gynecol Assoc

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Objective: To describe the distribution of abnormal uterine bleeding (AUB) type according to the polyp (AUB-P); adenomyosis (AUB-A); leiomyoma (AUB-L); malignancy and hyperplasia (AUB-M); coagulopathy (AUB-C); ovulatory dysfunction (AUB-O); endometrial (AUB-E); iatrogenic (AUB-I); and not yet classified International Federation of Gynecology and Obstetrics classification system in a medically underserved American inner-city population. Our secondary objective was to find an association between risk factors and type of AUB. Material and Methods: We conducted a descriptive cross-sectional analysis at our outpatient women’s health clinic located in the Bronx, New York City, from November 2016 to December 2019. Results: Among 390 patients, the most common AUB type was AUB-L (n=185, 47.4%), followed AUB-P (n=100, 25.6%), AUB-A (n=55, 14.1%), AUB-O (n=19, 4.9%), AUB-M (n=15, 3.8%), AUB-E (n=14, 3.6%) and AUB-I (n=2, 0.5%). Race was distributed as follows: Hispanic (68.2%), Black (25.9%), Caucasian (3.3%), and Asian (2.1%). Comorbidities included hypertension (36.4%), diabetes (15.6%), and thyroid disease (6.9%). The median age at diagnosis was significantly higher in AUB-M (59 years old, p<0.001), AUB-P (52.5 years old, p<0.001), AUB-E (51.5 years old, p=0.001) compared to AUB-L (46 years old). The median body mass index (BMI) was significantly higher in AUB-E (34.2 kg/m 2 , p=0.048) and AUB-O (32.6 kg/m 2 , p=0.038) compared to AUB-L (30 kg/m 2 ). Race was equally distributed among the AUB types. AUB-M (66.6%, p=0.002), AUB-E (57.1%, p=0.022), AUB-P (47%, p<0.001), and AUB-A (30.8%, p<0.001), had statistically significantly more cases of hypertension compared to AUB-L (28.1%). AUB-P (27%, p<0.001), AUB-M (26.6%, p=0.025), AUB-E (35.7%, p=0.001) and AUB-A (9%, p<0.001) had more patients with diabetes mellitus (DM) than AUB-L (3.3%). Conclusion: In an American population of medically underserved patients, the most common cause of AUB was leiomyoma and the most common race was Hispanic. Women with AUB-L were younger, with lower BMI, and with fewer cases of hypertension and DM when compared to other types of AUB.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 97%

“…Six previous studies from India and 1 from China reported a prevalence of AUB-P ranging from 2% to 16.2% ( 12 , 13 , 14 , 16 , 17 , 18 , 19 ).…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Abnormal uterine bleeding types according to the PALM-COEIN FIGO classification in a medically underserved American community

Sabre¹,

Serventi²,

Nuritdinova³

et al. 2021

J Turkish German Gynecol Assoc

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Clinical bleeding patterns and management of abnormal uterine bleeding in non-pregnant women: a cross-sectional study

Gupta,

Singh,

Aditya

et al. 2023

Int J Reprod Contracept Obstet Gynecol

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Background: Around 10 to 15 percent of women go through instances of unusual bleeding from their uterus at some point during their reproductive years. Additionally, up to one-third of women may come across irregular menstrual cycles. These irregularities often occur during two crucial phases in a woman's life: firstly, at the beginning of menstruation, which is known as menarche, and secondly, during the transition leading up to menopause, referred to as perimenopause. Aim of study was to determine the clinical bleeding patterns in nonpregnant women and its management. Methods: During the study period spanning from November 2021 to December 2022, a cross-sectional study examined non-pregnant females aged 15 to 55 experiencing abnormal vaginal bleeding (AUB) who provided consent. However, certain exclusion criteria were established to ensure that the study's findings remained pertinent to the target population. Females exhibiting vaginal bleeding attributed to pregnancy or pregnancy-related factors were excluded from the study, as were those with vaginal bleeding stemming from vaginitis, cervical benign, premalignant, or malignant conditions, or traumatic causes. Descriptive statistics were employed in the study. Results: Structural causes [PALM] accounts for 71 (61%) of cases whereas non-structural causes of chronic AUB account for 44 (39%) of cases. AUB-L, 45 (39.2%) was the most frequent finding in females with AUB. The second most common causes are AUB-O 23 (20%) followed by AUB-A 14 (12.2%), AUB-C 08(7%), AUB-M 07 (6.1%), AUB-E 06 (5.2%), AUB-P and AUB-I in 05 (4.3%) each and AUB-N 02 (1.7%). Conclusions: Focusing on Abnormal Uterine Bleeding (AUB), it was observed that AUB-L, attributed to leiomyomas, emerged as the most prevalent cause among affected females. Subsequently, AUB-O, arising from ovulatory dysfunction, and aub-a, linked to adenomyosis, ranked as the second and third most common causes, respectively. Among the clinical manifestations of AUB, prolonged bleeding was identified as the most frequent symptom, followed closely by heavy bleeding.

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Analysis of Risk Factors Associated with Benign and Malignant Uterine Pathologies in a Bleeding Clinic: A Prospective Cohort Study

Bel Hassani,

Bucella,

Rozenberg

et al. 2023

Preprint

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Clinico-pathological evaluation and etiological stratification of chronic AUB patients based on PALM-COEIN classification: A prospective study in tertiary care center of Nalgonda District

Cited by 4 publications

References 13 publications

Abnormal uterine bleeding types according to the PALM-COEIN FIGO classification in a medically underserved American community

Abnormal uterine bleeding types according to the PALM-COEIN FIGO classification in a medically underserved American community

Clinical bleeding patterns and management of abnormal uterine bleeding in non-pregnant women: a cross-sectional study

Analysis of Risk Factors Associated with Benign and Malignant Uterine Pathologies in a Bleeding Clinic: A Prospective Cohort Study

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