Clinicopathologic analysis of 14 cases of odontogenic myxoma and review of the literature

Abstract

BackgroundOdontogenic myxoma is a rare benign neoplasm that originates from odontogenic ectomesenchyme. There is no standard of care and recurrences are frequent after conservative surgical procedures.Material and MethodsA retrospective study conducted at a single cancer center, with analysis of medical records of all patients diagnosed with odontogenic myxoma from 1980 to 2010, along with a literature review.ResultsThere were 14 patients with diagnosis of odontogenic myxoma (OM). Most patients were female (78.6%) and Caucasian (100%), with ages ranging from 7 to 51 years (21.6 ± 11.6 years). The time period between the first symptom and first consultation ranged from 0 to 60 months (19.4 ± 19.97 months). The most frequent complaints were increased local volume or failure to tooth eruption. The most common tumor site was the mandible (11 cases, 78.5%). About radiological findings, most lesions were multilocular (9 cases, 64.3%) and with imprecise limits (12 cases, 85.7%). Surgery was performed in all cases and curettage was the most applied technique (10 cases, 71.4%). Three patients underwent mandibulectomy and complex reconstructions including iliac crest microvascular flap. Three patients had postoperative complications and 4 had local recurrences of the tumor. The follow up time ranged from 12 to 216 months (112 ± 70.8 months). All patients are without clinical and radiographic evidence of disease.ConclusionsOM is a locally aggressive and rare tumor. There is no gold standard surgical management and the therapeutic decision should be individualized taking into account the characteristics and extension of the tumor. Key words:Mandible, myxoma, odontogenic, odontogenic tumor.

Odontogenic Myxoma: Systematic review and bias analysis

“…In mandible, the simultaneous involvement of the anterior and posterior region occurred in 4.1% and in the maxilla in 2.98%. Some studies have not clearly demonstrated the OM localization 3,14,15,20,21,25,27,28,31,35‐38,45,48,50,52,53,57,60 . Previously to the treatments, 93.69% of OM was diagnosed by biopsy.…”

“…Diagnosis should involve a clinical, radiographic and microscopic features 5 . Surgical procedures are the best treatment modality for OM and involved curettage until total resection of bone affected 3,7,30 …”

“…Odontogenic myxoma (OM) is a rare benign tumour originated from odontogenic ectomesenchyme, 1 characterized by local invasion and tendency to reoccur 2 . It consists in 3 to 20% of all odontogenic tumours, with an incidence of approximately 0.07 new cases per million people per year 3,4 . The age range of the patients affected by this tumour normally ranges from 5 to 56 years, but most cases occur between the second and fourth decade of life, with no predilection for sex 2 .…”

“…The age range of the patients affected by this tumour normally ranges from 5 to 56 years, but most cases occur between the second and fourth decade of life, with no predilection for sex 2 . Mandible is the most affected region (two thirds of cases) 3 …”

“…Diagnosis of OM is based mainly on clinical and radiological and/or histopathological findings 5 . Clinically, it is characterized by slow growth, with potential to cause local bone destruction, cortical expansion, soft tissue infiltration, root resorption and tooth movement 3 . Radiographically, an unilocular or multilocular radiolucent image may be observed, with or without clearly defined borders 1 .…”