Clinicopathologic features, outcomes, and prognostic factors of testicular sarcoma: a population-based study

Bhambhvani, Hriday P.; Greenberg, Daniel S.; Kasman, Alex M.

doi:10.1007/s11255-020-02634-4

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…This distribution is consistent with all adult soft tissue sarcomas (1). Age at diagnosis has been repeatedly reported in different series, with a median value of 52-62 years (5,13,14). The median age of our patients was 57 years during diagnosis, which is consistent with earlier studies.…”

Section: Discussionmentioning

confidence: 83%

“…In previous studies, complete resection was considered to be among the most crucial prognostic markers ( 5 , 14 , 24 ). In the present study, 44 patients underwent surgical resection, including 35 patients with localized diseases and 9 patients with metastatic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…The above-mentioned tumors are most frequently observed in the retroperitoneum, extremities, trunk, and head and neck area ( 1 ). Visceral sarcomas except for gastrointestinal stromal tumors (GIST) rarely occur, and only a few research reports have been available, which were mainly individual case reports ( 5 , 6 ). Currently, no published research has investigated a significant number of patients with visceral sarcomas to the best of our knowledge, and therefore, little is known about the natural course, therapeutic approaches, and prognostic factors of these tumors.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathologic features, prognostic factors, and outcomes of visceral sarcomas: A retrospective 12-year single-center study

Yang

Liao

et al. 2022

Front. Oncol.

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BackgroundVisceral sarcomas are a rare form of soft tissue sarcoma. This study aimed to evaluate the survival and prognostic factors and effective treatments for visceral sarcomas.MethodsAll patients with visceral sarcoma referred to our center between January 2010 and December 2021 were retrospectively analyzed. The Kaplan-Meier method and a log-rank test were used for survival analysis.ResultsA total of 53 patients with visceral sarcoma were analyzed in this study with the median age at diagnosis of 57 (range, 24-77) years. Among them, 37 (69.8%) and 16 (30.2%) patients had localized and metastatic diseases at the initial presentation, respectively, and 44 patients underwent surgical resection. The median follow-up, event-free survival (EFS) and overall survival (OS) were 63.0 (range, 2-130), 42.0 months (95% confidence interval [CI] 10.879-73.121) and 45.0 months (95% CI 9.938-80.062), respectively. The 5-year EFS and OS rates were 44% and 46%, respectively. Univariate analysis of prognostic indicators illustrated that metastasis at presentation, surgery, surgical margin and the types of surgery were significantly associated with OS and EFS. In this study, combined chemotherapy or radiotherapy had no effects on EFS and OS.ConclusionPrimary visceral sarcoma is an uncommon and aggressive malignant tumor with a higher rate of local recurrence. In the largest cohort of visceral sarcomas in China to date, we identified metastases at presentation, surgery, surgical margin, and the types of surgery as independent predictors of survival. The combination of chemotherapy and radiotherapy did not affect survival.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathologic features, prognostic factors, and outcomes of visceral sarcomas: A retrospective 12-year single-center study

Yang

Liao

et al. 2022

Front. Oncol.

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“…The remaining (5%) involves non-germ cell tumors such as sex-cord stromal tumors, testicular lymphomas, and paratesticular tumors [sarcoma (liposarcoma, leiomyosarcoma, rhabdomyosarcoma)] ( 1 ). As a non-germ cell tumor, rhabdomyo-sarcoma of the testis is relatively rare in the clinic ( 2 ). It is often found by self-examination as the main complaint, and some patients may be comorbid with orchitis or epididymitis ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Rupture of Rhabdomyosarcoma of the Testis With Unilateral Ptosis: A Case Report and Literature Review

Liu

Song

et al. 2022

Front. Pediatr.

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Spontaneous rupture of testicular rhabdomyosarcoma is very rare. We report a case of spontaneous testicular rupture that was pathologically confirmed as rhabdomyosarcoma with unilateral blepharoptosis. The patient, a 19-year-old male, and his father had weakness of the left eyelid muscle. The patient was suspected to have a right inguinal hernia by a family doctor but was not treated further. 2 days later, there was skin itching in the right inguinal area, accompanied by redness, swelling and discomfort of the right scrotum, and the patient went to the local hospital again. Ultrasound examination showed that a contusion of the right testis may have been complicated with orchitis. Oral levofloxacin was ineffective. In addition, the swelling of scrotal increased significantly. He came to the emergency room of our hospital and also was treated with levofloxacin, but the pain was still not relieved. CT and ultrasound examination could not identify the cause of the disease. Exploration of the right scrotum was performed under general anesthesia and confirmed that the right testis had spontaneously ruptured. The pathological diagnosis was rhabdomyosarcoma of the right testis. Testicular rhabdomyosarcoma is clinically rare, and spontaneous rupture is even rarer. The pathogenesis of the disease needs to be further studied, and the diagnosis should be made on a case-by-case basis. Overall, the prognosis of testicular rhabdomyosarcoma is poor. As seen in this case, further study is required to determine whether there is some association between testicular rhabdomyosarcoma and ptosis. Unfortunately, the patient's family rejected a genetic examination because of financial difficulty. We only report a single case of this rare phenomenon here.

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Global, Regional, and National Burden of Soft Tissue and Other Extraosseous Sarcomas in Adolescents and Young Adults,1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021

Zhang,

Zheng,

Chen

et al. 2024

Preprint

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Clinicopathologic features, outcomes, and prognostic factors of testicular sarcoma: a population-based study

Cited by 3 publications

References 22 publications

Clinicopathologic features, prognostic factors, and outcomes of visceral sarcomas: A retrospective 12-year single-center study

Clinicopathologic features, prognostic factors, and outcomes of visceral sarcomas: A retrospective 12-year single-center study

Spontaneous Rupture of Rhabdomyosarcoma of the Testis With Unilateral Ptosis: A Case Report and Literature Review

Global, Regional, and National Burden of Soft Tissue and Other Extraosseous Sarcomas in Adolescents and Young Adults,1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021

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