Clinicopathologic study after submacular removal of choroidal neovascular membranes treated with verteporfin ocular photodynamic therapy

A new kind of labyrinth-like capillary is responsible for leakage from human choroidal neovascular endothelium, as investigated by high-resolution electron microscopy

“…However, this description would be helpful in understanding how far anti-VEGF therapy can cure subretinal edema and close leakages. It was also demonstrated earlier by electron microscopy that photodynamic therapy could not permanently close neovascular vessels in wet AMD [9].…”

Combined intravitreal bevacizumab and photodynamic therapy for neovascular age-related macular degeneration

“…However, in humans, PDT does not appear to lead to permanent and complete occlusion of the CNV [22,27]. Consequently, additional pharmacologic agents have been proposed to improve treatment efficacy.…”

Histological findings of a surgically excised myopic choroidal neovascular membrane after photodynamic therapy

“…The effects of PDT on human CNV have been documented in a few morphological studies in patients with AMD [4,8,20], whereas, to our knowledge, morphological features of surgically excised myopic CNV after PDT have been described only in two cases that have not shown improvement after PDT [15].…”