Clinicopathological characteristics and diagnostic performance of Wisteria floribunda agglutinin positive Mac-2-binding protein as a preoperative serum marker of liver fibrosis in hepatocellular carcinoma

Fujiyoshi, Masato; Kuno, Atsushi; Gotoh, Masao; Fukai, Moto; Yokoo, Hideki; Kamachi, Hirofumi; Kamiyama, Toshiya; Korenaga, Masaaki; Mizokami, Masashi; Narimatsu, Hisashi; Taketomi, Akinobu

doi:10.1007/s00535-015-1063-2

Cited by 54 publications

(73 citation statements)

References 26 publications

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“…[10–14] Although the diagnostic accuracy of WFA + -M2BP for liver fibrosis has not yet been validated outside Japan, previous Japanese studies demonstrated that it is useful for grading liver fibrosis and can be a useful predictor associated with clinical outcomes. [10–14,32,33] Thus, in the near future, this novel liver fibrosis biomarker should attract much attention in Western countries.…”

Section: Discussionmentioning

confidence: 99%

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A proposed predictive model for advanced fibrosis in patients with chronic hepatitis B and its validation

Nishikawa

Hasegawa²,

Ishii³

et al. 2016

Medicine

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We created a predictive model using serum-based biomarkers for advanced fibrosis (F3 or more) in patients with chronic hepatitis B (CHB) and to confirm the accuracy in an independent cohort.A total of 249 CHB patients were analyzed. To achieve our study aim, a training group (n = 125) and a validation group (n = 124) were formed. In the training group, parameters related to the presence of advanced fibrosis in univariate and multivariate analyses were examined, and a formula for advanced fibrosis was created. Next, we verified the applicability of the predictive model in the validation group.Multivariate analysis identified that gamma-glutamyl transpeptidase (GGT, P = 0.0343) and platelet count (P = 0.0034) were significant predictors of the presence of advanced fibrosis, while Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP, P = 0.0741) and hyaluronic acid (P = 0.0916) tended to be significant factors. Using these 4 parameters, we created the following formula: GMPH score = −0.755 − (0.015 × GGT) − (0.268 × WFA+-M2BP) + (0.167 × platelet count) + (0.003 × hyaluronic acid). In 8 analyzed variables (WFA+-M2BP, aspartate aminotransferase-to-platelet ratio index, FIB-4 index, prothrombin time, platelet count, hyaluronic acid, Forns index, and GMPH score), GMPH score had the highest area under the receiver operating characteristic (AUROC) curve for advanced fibrosis with a value of 0.8064 in the training group and in the validation group, GMPH score also had the highest AUROC (0.7782). In all subgroup analyses of the hepatitis B virus (HBV) status (HB surface antigen quantification, HBV-DNA quantification, and HBe antigen seropositivity), GMPH score in F3 or F4 was significantly lower than that in F0 to F2. In the above mentioned 8 variables, differences between the liver fibrosis stages (F0 to F1 vs F2, F2 vs F3, F3 vs F4, F0 to F1 vs F3, F0 to F1 vs F4, and F2 vs F4) for the entire cohort (n = 249) were all significant only in GMPH score.In conclusion, the GMPH scoring system may be helpful for detecting advanced liver fibrosis in patients with CHB.

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Section: Discussionmentioning

confidence: 99%

“…WFA + -M2BP is characterized by a fibrosis-related glycoalteration, and test results can be rapidly obtained with a bedside method. [10–14] …”

Section: Introductionmentioning

confidence: 99%

A proposed predictive model for advanced fibrosis in patients with chronic hepatitis B and its validation

Nishikawa

Hasegawa²,

Ishii³

et al. 2016

Medicine

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“…Thus, its cross-reactive potential severely limits its use for cancer biomarker detection. WFA is currently considered the most prominent diagnostic lectin against cholangiocarcinoma when compared with other homologous lectins (26,35) and the most discriminatory against altered N-glycans on Mac2-binding protein, a secretory N-glycoprotein with elevated expression levels during viral hepatitis induced liver cirrhosis (36,37).…”

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confidence: 99%

Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin

Haji-Ghassemi

Gilbert

Spence

et al. 2016

Journal of Biological Chemistry

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Neoplastic transformation often results in cells with unusual glycosylation patterns specific to the type and stage of different cancers, providing numerous venues for therapeutic and diagnostic reagents (1, 2). Lectins are non-catalytic proteins with strict specificity for individual mono-or oligosaccharides, which can make them powerful tools for detecting changes in the carbohydrate structure in glycoproteins and glycolipids.

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“…We recommend the use of platelet counts rather than serum WFA(+)-M2BP levels in the prediction of liver fibrosis in NASH, PBC, and AIH patients (Figure 1). Previous studies [12,13,14,15,16] have tried to show the effectiveness of this novel non-invasive biomarker for the diagnosis and evaluation of fibrosis and inflammation in various chronic liver diseases. In chronic hepatitis C patients, several studies have reported the effectiveness of several non-invasive biomarkers such as platelet levels, ferritin, and hyaluronic acid [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Kuno et al reported that a rapid and simple glycan-based immunoassay for WFA(+)-M2BP can quantify fibrosis [14]. There are many reports that support the quality of WFA(+)-M2BP in the assessment of fibrosis in HCV patients [15] and PBC patients [16]. Further study may be needed to validate the diagnostic utility of WFA(+)-M2BP in the diagnosis of fibrosis in the full range of chronic hepatitis patients.…”

Section: Introductionmentioning

confidence: 99%

Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases

et al. 2016

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Background: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a novel non-invasive marker of liver fibrosis. The goal of the study was to investigate whether the novel serum biomarker WFA(+)-M2BP or other non-invasive markers are useful for the prediction of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH), autoimmune hepatitis (AIH), and primary biliary cholangitis (PBC). Methods: We examined a significant correlation between serum WFA(+)-M2BP levels and histological staging of fibrosis in several chronic liver diseases, such as NASH, AIH, and PBC. Results: WFA(+)-M2BP could not predict hepatic fibrosis in these patients. We also showed that the level of platelet counts is a useful predictor of hepatic fibrosis progression in patients with NASH, AIH, and PBC. There was a significant correlation between staging of fibrosis and grading of activity in the liver in all groups except for AIH patients. Conclusion: Platelet counts can predict hepatic fibrosis in patients with NASH, AIH, or PBC. Clinicians should pay attention to the grading of liver activity in the use of WFA(+)-M2BP.

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Clinicopathological characteristics and diagnostic performance of Wisteria floribunda agglutinin positive Mac-2-binding protein as a preoperative serum marker of liver fibrosis in hepatocellular carcinoma

Cited by 54 publications

References 26 publications

A proposed predictive model for advanced fibrosis in patients with chronic hepatitis B and its validation

A proposed predictive model for advanced fibrosis in patients with chronic hepatitis B and its validation

Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin

Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases

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