Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups

Zhang, Yanyan; Wang, Diancan; Su, Jia-Zeng; Jia, Lingfei; Peng, Xin; Yu, Guang‐Yan

doi:10.1002/hed.24898

Cited by 49 publications

(63 citation statements)

References 40 publications

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“…In contrast with previous reports, gender predisposition was a significant prognostic factor among young patients in our study. Young and older female patients alike had improved OS and DSS compared to their male counterparts.…”

Section: Discussioncontrasting

confidence: 99%

“…Moreover, we did not find a higher incidence of poorly differentiated tumors in young patients compared to their older counterparts. This concurs with the findings of Zhang et al and others . Interestingly, although poorly differentiated tumors were associated with poor survival in older patients, this was not the case in the young cohort.…”

Section: Discussionsupporting

confidence: 93%

“…An added advantage of our study is the statistical power to compute DSS in addition to OS, an important metric that has not been performed in prior studies. Younger patients were also more likely to receive multimodality therapy, a finding corroborated by Zhang et al, suggesting that clinicians may be more inclined to aggressively treat OTSCC in younger patients.…”

Section: Discussionmentioning

confidence: 53%

“…Furthermore, we did not find an association between radiation treatment and improved survival rates in young patients. This is yet another interesting finding that warrants further study, especially in the context of the debate in clinical circles as to whether OTSCC in young patients represents a separate clinical entity with distinctive etiologic factors . Investigating the etiologies of OTSCC in young patients may provide clinicians with not only more informed pretreatment planning to improve survival rates, but also an approach to curb OTSCC's rising incidence.…”

Section: Discussionmentioning

confidence: 87%

“…This may be explained by the greater proportion of advanced TNM classification (III‐IV) in male patients, and the higher percentage of male smokers in the US . Although we were unable to determine smoking status of our patient population, previous reports have shown that smoking is an important prognostic factor in patients with OTSCC …”

Section: Discussionmentioning

confidence: 96%

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Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis

et al. 2018

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Objectives/Hypothesis To utilize the Surveillance, Epidemiology, and End Results (SEER) database to elucidate differences in predictors of survival in oral tongue squamous cell carcinoma (OTSCC) as stratified by age and sex. Study Design Retrospective, population‐based database analysis. Methods The SEER registry was utilized to calculate survival trends for patients with OTSCC between 1973 and 2012. Patient data were then stratified by age (≤40 years vs. >40 years) and sex, then analyzed with respect to race, stage, grade, and treatment modalities. Overall survival (OS) and disease‐specific survival (DSS) were calculated and compared. Results There were 16,423 cases of OTSCC identified, with 526 and 706 young female and male patients, respectively. Young female patients had improved OS and DSS as compared to young male patients (75% vs. 67% at 5 years), which is better than older patients (P < .001). Younger patients were more likely to receive surgery (P < .001) and combination surgery and radiation (P < .001) as compared to older patients. On multivariate analysis, tumor stage was uniformly associated with worse OS and DSS (P < .05), with surgery predicting improved OS and DSS in all groups except young females (P < .05). Higher tumor grade predicted worse OS and DSS in older patients, but not younger patients (P < .05). Conclusions OTSCC appears to present with relatively heterogeneous characteristics across different age groups and sexes. Despite the rising incidence of OTSCC in young individuals, our study demonstrates that young patients have improved survival rates compared to older patients. Level of Evidence NA Laryngoscope, 129:2076–2081, 2019

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 96%

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Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis

et al. 2018

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A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

et al. 2021

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While evidence suggests an increasing incidence of tongue cancer in young adults, published findings regarding the prognostic role of age at diagnosis are inconsistent. We performed a meta‐analysis of the literature to highlight key points that might help in understanding the association between age of oral tongue cancer patients at diagnosis and their prognosis. According to age at diagnosis, a systematic literature review of all published cohort studies assessing the recurrence risks and mortality associated with tongue cancer was conducted. We compared the risk estimates between patients aged >45 years and those aged <45 years at diagnosis. Random‐effects models were used to calculate summary relative risk estimates (SRRs) according to different clinical outcomes and sources of between‐study heterogeneity (I2) and bias. We included 31 independent cohort studies published between 1989 and 2019; these studies included a total of 28,288 patients. When risk estimations were not adjusted for confounders, no significant association was found between age at diagnosis and overall survival (OS). Conversely, after adjustment for confounders, older age at diagnosis was associated with a significantly increased risk of mortality. The difference between SRRs for adjusted and unadjusted estimates was significant (p < 0.01). Younger patients had a significantly higher risk of local recurrence. Younger patients with oral tongue cancer have better OS but a greater risk of recurrence than older patients. These findings should be validated in a large prospective cohort study which considers all confounders and prognostic factors.

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Tongue cancer epidemiology in Brazil: incidence, morbidity and mortality

et al. 2018

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Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups

Abstract: Young patients had a tendency of higher death rate caused by recurrence or metastasis than middle-age and older patients; therefore, a larger case sample is needed for further confirmation.

Cited by 49 publications

References 40 publications

Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis

Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

Tongue cancer epidemiology in Brazil: incidence, morbidity and mortality

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