Clinicopathological correlation of 3 patterns of calcification in a hydrophilic acrylic intraocular lens

Abstract

We present 3 cases of opacification in the Biocomfold 92S intraocular lens (IOL), with a documented increase in the opacification over time in 1 case. Histopathological analysis revealed the opacification was caused by calcification in the IOL's optic material. The pattern of calcium deposition, however, was different in each IOL. The causative mechanisms for this complication are unclear. Further research is warranted.

Microscopic analysis of opacification in Ioflex® hydrophilic acrylic intraocular lenses

“…In case 3, during a one-month period the uncorrected visual acuity decreased from 20/150 to 20/400 on the right eye. This demonstrates the progressive nature of the process of calcification in the Ioflex ® lenses, which was also previously described in another hydrophilic IOL (6) . The mean period between first surgery and explantation of lenses was 36.8 months, with minimum being 31 and maximum 41.…”

“…Calcification on the surface and in the substance of the lens in hydrophilic acrylic IOLs has been well documented (6)(7)(8)(9)(10) . However, to the best of our knowledge this is the first peer-reviewed report on opacification of the Mediphacos Ioflex ® IOL.…”

Scleral fixation technique using a hydrophobic foldable intraocular lens with ring-shaped connecting bridges

“…5 However, foldable IOLs may present difficulties in IOL centration 6 or develop glistenings and undergo opacification. [7][8][9][10][11][12] In 2012, a hydrophobic foldable IOL with ring-shaped connecting bridges (Figure 1, A) between the haptic and the optic (enVista MX60, Bausch & Lomb) became available. Its design allows the surgeon to use the ringshaped connecting bridges for new fixation suture sites.…”

Ungewöhnliche Kalzifikation intraokularer Kunstlinsen nach vitreoretinalem Eingriff mit Silikonölendotamponade

“…Ähnliches gilt auch für Triamcinolon, welches eine gewisse Haftungsaffinität, insbesondere bei hydrophilen Linsen, besitzt [9]. Interessanterweise und im Gegensatz zu dem hier präsentierten Verkalkungsmuster, welches nur die Linsenoberfläche betrifft, lokalisieren Analysen in hydrophilen Linsen ein ähnliches Verkalkungsmuster im Inneren des IOLMaterials unterhalb der Linsenoberfläche in einer charakteristischen Anordnung, parallel zu der anterioren/posterioren Kurvatur der Linse [10][11][12][13]. Obwohl es keine definitive Erklärung für dieses Phänomen gibt, stellt es möglicherweise eine Variation des gleichen Verkalkungsprozesses in einem unterschiedlichen Diffusions-/Absorptionsmuster dar.…”