Clinicopathological differences between familial colorectal cancer type X and sporadic cancer in an isolated area of spain

Medina-Arana, Vicente; Rahy‐Martín, Aida Cristina; Delgado‐Plasencia, Luciano; Martı́nez-Riera, Antonio; León-Ayllón, Diana C.; Rodríguez-Castellano, Desiré; Bravo‐Gutiérrez, Alberto; Fernández-Peralta, Antonia M.; González-Aguilera, Juan J.

doi:10.1111/codi.13532

Cited by 1 publication

(1 citation statement)

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“…Patients with FCCX have an approximately larger number of synchronous tumors, but this number does not reach the level of statistical significance. Recurrence is noticeably higher in FCCX than in sporadic CRC [ 85 ]. FCCX has a lower proportion of peritumoral lymphocytes and Crohn-like reactions.…”

Section: Familial Colorectal Cancer Type X (Fccx)mentioning

confidence: 99%

Hereditary Nonpolyposis Colorectal Cancer and Cancer Syndromes: Recent Basic and Clinical Discoveries

Chen

Liu

2018

Journal of Oncology

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Approximately one-third of individuals diagnosed with colorectal cancer have a family history of cancer, suggesting that CRCs may result from a heritable component. Despite the availability of current gene-identification techniques, only 5% of all CRCs emerge from well-identifiable inherited causes for predisposition, including polyposis and nonpolyposis syndromes. Hereditary nonpolyposis colorectal cancer represents a large proportion of cases, and robustly affected patients are at increased risk for early onset, synchronous, and metachronous colorectal malignancies and extracolonic malignancies. HNPCC encompasses several cancer syndromes, such as Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X, which have remarkable clinical presentations and overlapping genetic profiles that make clinical diagnosis a challenging task. Therefore, distinguishing between the HNPCC disorders is crucial for physicians as an approach to tailor different recommendations for patients and their at-risk family members according to the risks for colonic and extracolonic cancer associated with each syndrome. Identification of these potential patients through epidemiological characteristics and new genetic testing can estimate the individual risk, which informs appropriate cancer screening, surveillance, and/or treatment strategies. In the past three years, many appealing and important advances have been made in our understanding of the relationship between HNPCC and CRC-associated syndromes. The knowledge from the genetic profile of cancer syndromes and unique genotype-phenotype profiles in the different syndromes has changed our cognition. Therefore, this review presents and discusses HNPCC and several common nonpolyposis syndromes with respect to molecular phenotype, histopathologic features, and clinical presentation.

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Section: Familial Colorectal Cancer Type X (Fccx)mentioning

confidence: 99%