Clinicopathological features and malignant transformation of oral lichen planus: A 12-years retrospective study

Bardellini, Elena; Amadori, Francesca; Flocchini, Pierangela; Bonadeo, Sara; Majorana, Alessandra

doi:10.3109/00016357.2012.734407

Cited by 46 publications

(31 citation statements)

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“…122 Hemidesmosomes, together with the anchoring filaments, form 123 the hemidesmosomes anchoring filament complex, which plays an im- group of diseases and only a few describe the epidemiological features 156 of the whole spectrum of autoimmune diseases in particular population. 157 Studies from Eastern Europe show that pemphigus is the most common 158 autoimmune blistering disease with an estimated incidence and preva- 159 lence of 4 and 24.8 per 100 000 inhabitants, respectively [10]. Similar 160 results also emerged in studies conducted in Western Asia, East Asia 161 and Africa, where pemphigus was also found to be the most prevalent 162 autoimmune bullous dermatose [11][12][13].…”

mentioning

confidence: 56%

Oral mucosal manifestations of autoimmune skin diseases

Mustafa

Porter

Smoller

et al. 2015

Autoimmunity Reviews

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mentioning

confidence: 56%

Oral mucosal manifestations of autoimmune skin diseases

Mustafa

Porter

Smoller

et al. 2015

Autoimmunity Reviews

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“…Lichen planus (LP) is a chronic inflammatory disease of stratified squamous epithelia that affects 0.2–4% of the general population, with a predilection for women (63–67%) . Several genetic and environmental factors such as hepatitis C infection, hypertension, depression and rheumatologic disorders have been reported to be associated with LP .…”

Section: Introductionmentioning

confidence: 99%

“…Lichen planus (LP) is a chronic inflammatory disease of stratified squamous epithelia that affects 0.2-4% of the general population, with a predilection for women (63-67%). [1][2][3][4][5] Several genetic and environmental factors such as hepatitis C infection, hypertension, depression and rheumatologic disorders have been reported to be associated with LP. 1 Although recent data suggest a primary pathogenic role of autoreactive cytotoxic T cells inducing keratinocyte apoptosis, the triggering antigen and exact mechanisms involved remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Distinct interferon‐gamma and interleukin‐9 expression in cutaneous and oral lichen planus

Weber

Schlapbach

Stuck

et al. 2016

Acad Dermatol Venereol

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“…His lesions had clinical WHO criteria for OLP, and he also had typical lichen affection in nails (nail pterygium). Therefore patients diagnosed with OLP must be followed up, as well as those with OLR, especially in erosive, atrophic, bullous and keratotic forms, for early diagnosis of malignant transformation if that occurs (21). …”

Section: Discussionmentioning

confidence: 99%

Determination of cytokeratins 1, 13 and 14 in oral lichen planus

Gutierrez¹,

Innocenti²,

Cippitelli³

et al. 2014

Med Oral

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Introduccion: Cytokeratins (CK) are molecules of the cytoskeleton that contribute to the cellular differenciation. We studied the expression of CK1, CK13 and CK14 in thirty-three patients with OLP. The biopsied lesions were located in the dorsal surface of the tongue, the palatal keratinized mucosa and the nonkeratinized buccal mucosa. Objectives: This study aimed to determine the expression of CK1, CK13 and CK14 in oral lichen planus (OLP) and its relations with: clinical patterns, prognosis, drugs and tobacco intake and histopathological features. Study Design: Immunohistochemical analysis, retrospective, descriptive, observational and no randomized study. Results: No significant difference was observed in the expression of CK1 in patients with or without drug treatment. No association was found with the amount of drugs intake or smoking nor with the histopathological features examined. Samples immunostained with CK13 were all positive in the suprabasal layers, and 13 of them in the basal layer. In these last ones, statistical analysis showed significance in the grade of vacuolization of the basal layer (p=0.023) and in the degree of exocytosis (p=0.0025), this, making the degree of affection higher for both parameters. Thirty-two tissue sections were immunostained with CK14. CK14 was expressed in the basal layer in 97% of samples and in the suprabasal layer in 94% of samples. Conclusions: The three CK were altered in OLP. CK1 does not have a direct connection with the presence of orthokeratosis. The finding of the CK13 in the basal layer is related to the agression of the lymphocytic infiltration in the epithelium, due to the basal stratum vacuolization and the increase in lymphocytic exocitosis. The presence of CK14 in the suprabasal stratums is not a parameter to predict malignancy. The CK in OLP do not follow the normal pattern of keratinized or non-keratinized mucosa. Key words:Basal cell vacuolization, CK1, CK13, CK14, cytokeratin, lymphocytic exocytosis, oral lichen planus.

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Clinicopathological features and malignant transformation of oral lichen planus: A 12-years retrospective study

Abstract: At present, OLP is accepted as being a potential malignant disorder, therefore lifelong follow-up is recommended.

Cited by 46 publications

References 32 publications

Oral mucosal manifestations of autoimmune skin diseases

Oral mucosal manifestations of autoimmune skin diseases

Distinct interferon‐gamma and interleukin‐9 expression in cutaneous and oral lichen planus

Determination of cytokeratins 1, 13 and 14 in oral lichen planus

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