1982
DOI: 10.1002/j.1552-4604.1982.tb05711.x
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Clobazam Kinetics: Intrasubject Variability and Effect of Food on Absorption

Abstract: The kinetics of single 20-mg oral doses of clobazam was determined on two occasions in 12 healthy male volunteers. Clobazam was given in the fasting state on one occasion and following a standard breakfast on another. Compared with the fasting state, administration of clobazam with food reduced mean peak plasma concentrations (465 vs. 333 ng/ml, P less than 0.01), and prolonged the time to reach peak concentration (1.7 vs. 2.5 hours after dosage, P less than 0.1). Total area under the curve nor the extent of f… Show more

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Cited by 44 publications
(19 citation statements)
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“…This is consistent with prior reports indicating that withinindividual variations in drug elimination and clearance are far smaller than differ ences observed between individuals [46,[49][50][51]-…”
Section: Discussionsupporting
confidence: 81%
See 1 more Smart Citation
“…This is consistent with prior reports indicating that withinindividual variations in drug elimination and clearance are far smaller than differ ences observed between individuals [46,[49][50][51]-…”
Section: Discussionsupporting
confidence: 81%
“…In all groups, abso lute bioavailability of antipyrine adminis tered orally in the fasting state was not re lated to age and, as reported previously [32,42,43], was not significantly less than 100%. Coadministration of antipyrine with food slowed the rate of absorption in all groups, similar to the delay in absorption observed when many other drugs are given postprandially [44][45][46][47][48]. Coadministration of antipy rine with food, however, did not importantly alter the essentially complete bioavailability of orally administered antipyrine, nor were there any differences attributable to age.…”
Section: Discussionmentioning
confidence: 78%
“…injected into the chromatogram under the Plasma phenytoin and carbamazepine confollowing conditions: mobile phase 70:30 mix-centrations were measured using enzyme ture of K2H2PO4 (pH 6.8): acetonitrile; column: immunoassay (EMIT, Syva) in samples taken at the following times after clobazam administration -2, 4,6,12,24,72,96,144,192 values reported previously (Rupp et al, 1979;Tedeschi et al, 1981;Divoll et al, 1982). That induction of clobazam metabolism is the likely explanation for the above finding is supported by two observations: first, the elimination half-life of antipyrine in the epileptic patients was significantly reduced compared with the normal volunteers (Davies et al, 1973).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, using peak concentrations requires accounting for the fact that food does not influence the extent of clobazam absorption but may slow the absorption rate. 93,94 …”
Section: Discussionmentioning
confidence: 99%