CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

DeBruyne, Jason P.; Weaver, David R.; Reppert, Steven M.

doi:10.1038/nn1884

Cited by 432 publications

(354 citation statements)

References 13 publications

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“…Characterization of affective behaviors in the Clock -/-mouse, where the CLOCK protein is completely absent but rhythms are intact (Debruyne et al, 2006) may discriminate between circadian and non-circadian roles of CLOCK in the regulation of mood. Double-knockouts of Clock and Npas2 could also be informative (DeBruyne, Weaver, & Reppert, 2007).…”

Section: Clock Genementioning

confidence: 99%

The role of the circadian clock in animal models of mood disorders.

Landgraf¹,

McCarthy²,

Welsh³

2014

Behavioral Neuroscience

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An association between circadian clock function and mood regulation is well established and has been proposed as a factor in the development of mood disorders. Patients with depression or mania suffer disturbed sleep–wake cycles and altered rhythms in daily activities. Environmentally disrupted circadian rhythms increase the risk of mood disorders in the general population. However, proof that a disturbance of circadian rhythms is causally involved in the development of psychiatric disorders remains elusive. Using clock gene mutants, manipulations of sleep–wake and light–dark cycles, and brain lesions affecting clock function, animal models have been developed to investigate whether circadian rhythm disruptions alter mood. In this review, selected animal models are examined to address the issue of causality between circadian rhythms and affective behavior.

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Section: Clock Genementioning

confidence: 99%

The role of the circadian clock in animal models of mood disorders.

Landgraf¹,

McCarthy²,

Welsh³

2014

Behavioral Neuroscience

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“…In vertebrates, three basic helix-loophelix Perid-Aryl hydrocardon receptor nuclear translocatorSingle-minded (PAS) (PER-ARNT-SIM) domain-containing transcription factors, called CLOCK, NPAS2 and BMAL, constitute the positive elements. 3,23) CLOCK or NPAS2 heterodimerizes with BMAL to form an transcriptionally active complex that binds to E-box elements (CACGTG) present in the promoters of members of the Period (Per) and Cryptochrome (Cry) gene families (Fig. 1).…”

Section: The Physiological Functions Of Core Circa-dian Regulatorsmentioning

confidence: 99%

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

Uchida

Hirayama

Nishina

2010

Biological & Pharmaceutical Bulletin

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INTRODUCTIONFrom bacteria to humans, almost all organisms can adapt the timing of their physiology to the cyclic changes of their environment, thanks to a naturally-selected intrinsic timekeeping system called the circadian clock. 1) The circadian clock enhances the physiological efficiency and survival of an organism by organizing its behavior and body functions. 2,3) During the circadian day, the organism's physiology is given over to catabolic processes, whereas the anabolic functions of growth, repair and consolidation occur at night. To achieve this schedule in mammals, the circadian clock regulates a number of physiological functions, including sleep and wakefulness, food intake, body temperature, cardiovascular and renal activity, hormone production, hepatic metabolism and immune responses. 4,5) Accordingly, disruption of the circadian clock in humans has been linked to profound effects on health, including insomnia, stomach ailments, depression and cancer. 4,5) In most organisms, the molecular mechanisms underlying the establishment and maintenance of biological rhythms comprise interconnected transcription-translation feedback loops in which some clock factors repress their own transcription once they have attained critical levels. 2,3) These oscillators have the property of being endogenous and cellautonomous systems that maintain their rhythm in the absence of external time cues. 6) Both vertebrates and invertebrates have circadian oscillators scattered throughout their bodies. 7,8) In mammals, the circadian system is composed of both central and peripheral oscillators. 7) The mammalian central clock is located in the suprachiasmatic nucleus (SCN) within the anterior hypothalamus of the brain. 9) This central clock acts as a coordinator and provides time signals via both neural and humoral routes that entrain independent peripheral clocks. Dysfunction of the central clock does not inactivate the peripheral clocks but instead causes individual peripheral oscillators to become temporally uncoupled. [10][11][12] To guarantee that an organism's behavior remains tied to the rhythms of its environment, the circadian clock must be able to reset itself in response to environmental cues. 9,13,14) The main environmental stimulus for organisms is light, which is provided in day-night cycles. Mammals have no photoreceptors in peripheral tissues, 15) so that the effect of light on peripheral clocks is indirect. 13) For the mammalian clock, the SCN integrates photic cues from the retina and uses neural and humoral signals to transmit this information to peripheral clocks, synchronizing them. [16][17][18] This communication between the central and peripheral clocks results in the seamless regulation of fundamental physiological functions. 4,8) Interestingly, peripheral clocks can also respond directly to SCN-independent signals such as feeding and temperature change. 19,20) However, the physiological role of SCN-independent responses of peripheral clocks is not yet fully understood. A recent study has reported that ...

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“…C'est ce que démontrent plusieurs études dans lesquelles des gènes (gènes de l'horloge) indispensables à l'expression de la rythmicité circadienne ont été surexprimés ou supprimés de façon spécifique dans certains tissus [7][8][9][10]43]. Cette synthèse fait le point sur les connaissances actuelles dans ces domaines, notamment sur le rôle exact d'un de ces gènes de l'horloge, Clock, qui a fait l'objet d'une série d'articles publiés récemment [11][12][13].…”

Section: Rôle Et Organisation Hiérarchique Du Système Circadienunclassified

“…DeBruyne et al [12]) ont donc produit des souris invalidées à la fois pour Clock et Npas2. Ces souris sont immédiatement Figure 1).…”

Section: Synchronisation Et Redondance Sont Nécessaires à Une Horlogeunclassified

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Redondance génétique et synchronisation cellulaire dans les horloges circadiennes

Dardente¹

2008

Med Sci (Paris)

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CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Cited by 432 publications

References 13 publications

The role of the circadian clock in animal models of mood disorders.

The role of the circadian clock in animal models of mood disorders.

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

Redondance génétique et synchronisation cellulaire dans les horloges circadiennes

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