Clomiphene citrate challenge test in the assessment of ovarian reserve before controlled ovarian hyperstimulation for intracytoplasmic sperm injection

Kahraman, Semra; Vıcdan, Kubilay; Işık, Ahmet Zeki; Özgün, O.D.; Alaybeyoglu, L.; Polat, G.; Biberoğlu, Kutay

doi:10.1016/s0301-2115(97)02742-5

Cited by 20 publications

(18 citation statements)

References 19 publications

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“…They showed that in the 141 cases with normal test results, the outcomes of the subsequent ICSI cycle were better than in the 57 patients with abnormal test results. Although these results were interesting and sound we could not find, in this paper (Kahraman et al, 1997), any mention of the predictive value of day 3 LH measurement. In the present Letter to the Editor, they extended their observation to 464 ICSI cycles, evaluating whether or not a low (Ͻ3 mIU/ml) day 3 LH value is predictive of a poor response to ovarian stimulation.…”

contrasting

confidence: 62%

“…and just stated that the oestradial peak on the day of HCG administration and the number of follicles Ͼ15 mm in diameter were significantly lower in patients whose day 3 LH was Ͻ3 mIU/ml in a small patient population. We previously showed the effectiveness of clomiphene citrate challenge tests in the prediction of poor outcome in patients undergoing intracytoplasmic sperm injection (ICSI) (Kahraman et al, 1997). We also evaluated the performance of day 3 LH values for predicting the cycle outcome in patients undergoing ICSI in a large group.…”

mentioning

confidence: 99%

“…The data they presented are indeed in apparent, perfect agreement with our results. These authors previously reported a positive predictive value of a clomiphene citrate challenge test in the assessment of ovarian reserve before ovarian stimulation for intracytoplasmic sperm injection (ICSI) performed for severe male infertility (Kahraman et al, 1997). In this paper, the authors reported data on 198 women who underwent a challenge test before ICSI.…”

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confidence: 99%

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Low day 3 luteinizing hormone values are predictive of reduced response to ovarian stimulation

Vicdan¹

1999

Human Reproduction

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confidence: 62%

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confidence: 99%

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Low day 3 luteinizing hormone values are predictive of reduced response to ovarian stimulation

Vicdan¹

1999

Human Reproduction

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“…Loumaye et al evaluated CCCT by defining a threshold value of 26 IU/L as the sum of cycle day 3 and 10 FSH values and concluded that predictive value of an abnormal test for failing to conceive was 100% (28). Recently, it was reported that an abnormal CCCT had a positive predictive value of 93% for pregnancy and a negative predictive value of 80% for cycle cancellation (30). Furthermore, it was reported in a biopsy study that CCCT was the most accurate to reflect follicular density as compared to basal FSH and gonadotropin-releasing hormone agonist test (31).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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Purpose : To compare basal and clomiphene citrate (CC) induced follicle-stimulating hormone (FSH), estradiol (E 2 ), and inhibin B levels with ultrasound indices of ovarian reserve in infertile women and to test the prognostic value of these tests on response to ovarian stimulation in in vitro fertilization (IVF). Methods : Fifty-six patients had basal and CC induced serum hormone levels and ultrasound measured mean ovarian volume (MOV) and mean antral follicle counts (MFC). Thirty-two patients were then appropriately selected to have a total of 41 cycles of IVF/ICSI treatment. Results : Women with diminished ovarian reserve had lower MOV, MFC, day 3 and day 10 inhibin B levels ( p < 0.001). Only basal and CC induced FSH and inhibin B correlated with MOV and MFC. Poor responders in IVF/ICSI had higher basal FSH ( p < 0.05), lower basal and induced inhibin B levels ( p < 0.05), and lower MOV and MFC ( p < 0.01) than normal responders. Ovarian volume alone was better than age and basal hormones in predicting poor ovarian response, while abnormal CC test was the only independent significant factor in predicting ovarian response. However, age was the only independent predictor of pregnancy in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion : CC test and ovarian volume are better than other hormonal and sonographic tests in predicting the response to ovarian stimulation in IVF cycles.

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“…Until recently, evaluation of ovarian reserve and prediction of IVF success focused on hormonal parameters that mainly reflect granulosa cell function. While most available tests are based on measuring baseline levels, such as those of FSH [1,2], anti-Müllerian hormone [AMH, [3][4][5][6], inhibin B [7][8][9], basal estradiol-E 2 [10][11][12] or antral follicle count [11,[13][14][15], some dynamic tests were developed to predict ovarian reserve by its response to certain stimuli, such as clomiphene citrate challenge test [CCCT - [16][17][18][19], exogenous FSH ovarian reserve test and gonadotropin releasing hormone agonist stimulation test . However, inconsistencies in the prognostic value for IVF success in these tests limit their clinical applicability.…”

Section: Introductionmentioning

confidence: 99%

The value of human chorionic gonadotropin stimulation test in predicting ovarian response during in-vitro fertilization

Ben‐Meir

Shveiky

Zivi

et al. 2011

J Assist Reprod Genet

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Purpose To assess the predictive value of human Chorionic Gonadotropin (hCG) theca-stimulation test for ovarian reserve in women undergoing in-vitro fertilization (IVF) treatments. Methods 39 women were included in the study. All participants received a single hCG 10000 IU injection on cycle day 2-3. Serum levels of estradiol, testosterone, androstenedione and 17-OH progesterone were measured prior to the injection and on days 1, 3 and 7 following the injection. hCG-induced hormone levels were compared with ovarian response during the subsequent IVF cycle. Results There were 11 good responders (>10 oocytes) and 22 low responders (<3 oocytes). Before hCG stimulation serum E2 levels were higher in low responders compared to good responders (370.3±443 vs. 138.3±54 pmol/ml). Following hCG stimulation, day 3 androstendione levels showed an increase in good responders compared to low responders. The ratio between day 3 androstendione and day 0 estradiol was significantly different between the two groups (p=0.03). ROC analysis of this test revealed area = 0.837 (good prediction), which was much better than day 3 FSH (area = 0.635, poor prediction).Conclusions These preliminary results demonstrate the potential use of the hCG theca stimulation test in differentiating between good and poor responders. Larger series are needed for further verification of the test in routine clinical application.

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Clomiphene citrate challenge test in the assessment of ovarian reserve before controlled ovarian hyperstimulation for intracytoplasmic sperm injection

Cited by 20 publications

References 19 publications

Low day 3 luteinizing hormone values are predictive of reduced response to ovarian stimulation

Low day 3 luteinizing hormone values are predictive of reduced response to ovarian stimulation

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

The value of human chorionic gonadotropin stimulation test in predicting ovarian response during in-vitro fertilization

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